Development of an automated end-to-end next generation sequencing assay to detect all classes of genetic variant in a single diagnostic test

  • Karsan, Aly A. (PI)
  • Marra, Marco A. (CoPI)
  • Birol, Inanc (CoPI)
  • Bosdet, Ian I. (CoPI)
  • Coope, Robin J.N. (CoPI)
  • Ho, Cheryl (CoPI)
  • Kennecke, Hagen (CoPI)
  • Moore, Richard A. (CoPI)
  • Ratnarajah, Edward E. (CoPI)
  • Swanson, Lucas Allan L.A. (CoPI)
  • Watson, Peter Hamilton P.H. (CoPI)
  • Zhao, Yongjun (CoPI)

Project: Research

Grant Details

Description

Each year more than 190,000 Canadians are diagnosed with cancer and about 77,000 die from the disease. Genetic testing of tumor tissue is required for most types of cancer to help make a diagnosis and to choose treatments. New methods are now being developed that can test blood to detect genetic changes in the tumor. Blood tests would avoid surgery, may be cheaper and might be useful for following the size of a patient's tumor. The aim of this project is to create an automated single genetic test that will be able to detect many cancer genetic changes at once, and can be used either on the tumor tissue or on blood. The test will be used to help make a diagnosis, and also possibly to monitor whether a patient is responding to treatment, or whether the cancer has returned. We will work with physicians at the BC Cancer Agency to make the reporting of the test results quick and convenient, and determine how this new test would change the management of cancer patients. We expect the test will be used in several provinces and research groups through our clinical testing laboratory, and help improve the management of cancer patients.

StatusFinished
Effective start/end date04/1/1603/31/19

Funding

  • Institute of Cancer Research: $342,182.00

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