2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

C. Ndumele; Chiadi E. Ndumele; Fatima Rodriguez; Dave L. Dixon; Sadiya S. Khan; Debabrata Mukherjee; Mandeep Bajaj; Sripal Bangalore; Biykem Bozkurt; Khadijah Breathett; Shoa L. Clarke; Ian H. de Boer; David H. Ellison; Lorraine S. Evangelista; Sean P. Heffron; Dhruv S. Kazi; Ambar Kulshreshtha; Ildiko Lingvay; Cecilia C. Low Wang; Claudia A. Mercado; John Magaña Morton; Ian J. Neeland; Neha Pagidipati; Tiffany M. Powell-Wiley; Janani Rangaswami; Goutham Rao; Nosheen Reza; Anum Saeed; Wendy St. Peter; J. Bradley Starks; Madeline Sterling; Amy W. Talbot; Andrew H. Tran; Katherine R. Tuttle; Lisa B. VanWagner; Amanda R. Vest; Salim S. Virani; Nicole Bhave; Amit Khera; Kevin M. Alexander; Alison L. Bailey; Marc P. Bonaca; Tara I. Chang; Cyrille K. Cornelio; Maria Rosa Costanzo; Colette DeJong; Adam DeVore; Patrick O. Gee; Beverly B. Green; Jennifer B. Green; Scott Kahan; Anuradha Lala; Melissa Magwire; Michael Miller; Katie Moegenberg; Elif Oral; Carl E. Orringer; Kershaw V. Patel; Sonali Patel; Jane E.B. Reusch; Philip Schauer; Daniel E. Weiner

doi:10.1161/CIR.0000000000001453

2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

C. Ndumele
, Chiadi E. Ndumele
, Fatima Rodriguez
, Dave L. Dixon
, Sadiya S. Khan
, Debabrata Mukherjee
, Mandeep Bajaj
, Sripal Bangalore
, Biykem Bozkurt
, Khadijah Breathett
, Shoa L. Clarke
, Ian H. de Boer
, David H. Ellison
, Lorraine S. Evangelista
, Sean P. Heffron
, Dhruv S. Kazi
, Ambar Kulshreshtha
, Ildiko Lingvay
, Cecilia C. Low Wang
, Claudia A. Mercado

John Magaña Morton, Ian J. Neeland, Neha Pagidipati, Tiffany M. Powell-Wiley, Janani Rangaswami, Goutham Rao, Nosheen Reza, Anum Saeed, Wendy St. Peter, J. Bradley Starks, Madeline Sterling, Amy W. Talbot, Andrew H. Tran, Katherine R. Tuttle, Lisa B. VanWagner, Amanda R. Vest, Salim S. Virani, Nicole Bhave, Amit Khera, Kevin M. Alexander, Alison L. Bailey, Marc P. Bonaca, Tara I. Chang, Cyrille K. Cornelio, Maria Rosa Costanzo, Colette DeJong, Adam DeVore, Patrick O. Gee, Beverly B. Green, Jennifer B. Green, Scott Kahan, Anuradha Lala, Melissa Magwire, Michael Miller, Katie Moegenberg, Elif Oral, Carl E. Orringer, Kershaw V. Patel, Sonali Patel, Jane E.B. Reusch, Philip Schauer, Daniel E. Weiner

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

AIM – The “2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome” retires, replaces, and expands upon the “2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults.” The primary intended audience for this guideline is clinicians who care for patients across the spectrum of cardiovascular-kidney-metabolic syndrome, an interrelated condition characterized by the interconnections among metabolic risk factors (including obesity and type 2 diabetes), chronic kidney disease, and cardiovascular disease. METHODS – A comprehensive literature search was conducted from October 29, 2024, to April 14, 2025, to identify clinical studies, systematic reviews and meta-analyses, and other evidence conducted on human subjects that were published since 2015 in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. STRUCTURE – The focus of this clinical practice guideline is to create a living, working document that provides current knowledge in the field of cardiovascular-kidney-metabolic syndrome aimed at all practicing cardiologists, endocrinologists, nephrologists, and primary care and specialty clinicians who manage these patients.

Original language	English
Journal	Circulation
DOIs	https://doi.org/10.1161/CIR.0000000000001453
State	Accepted/In press - 2026

Keywords

AHA Scientific Statements
MASLD
atherosclerosis
atrial fibrillation
blood pressure/hypertension
cardiovascular disease
cardiovascular kidney metabolic
coronary disease
diabetes
diagnosis
heart failure
kidney disease(s), chronic
management, cardiovascular kidney metabolic
metabolic syndrome
overweight/obesity
peripheral artery disease
renal insufficiency
risk factors
screenings
secondary prevention
venous thromboembolism
weight loss

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Ndumele, C., Ndumele, C. E., Rodriguez, F., Dixon, D. L., Khan, S. S., Mukherjee, D., Bajaj, M., Bangalore, S., Bozkurt, B., Breathett, K., Clarke, S. L., de Boer, I. H., Ellison, D. H., Evangelista, L. S., Heffron, S. P., Kazi, D. S., Kulshreshtha, A., Lingvay, I., Low Wang, C. C., ... Weiner, D. E. (Accepted/In press). 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. https://doi.org/10.1161/CIR.0000000000001453

@article{9b391dddfed9453ead7ed80c80668310,

title = "2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines",

abstract = "AIM – The “2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome” retires, replaces, and expands upon the “2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults.” The primary intended audience for this guideline is clinicians who care for patients across the spectrum of cardiovascular-kidney-metabolic syndrome, an interrelated condition characterized by the interconnections among metabolic risk factors (including obesity and type 2 diabetes), chronic kidney disease, and cardiovascular disease. METHODS – A comprehensive literature search was conducted from October 29, 2024, to April 14, 2025, to identify clinical studies, systematic reviews and meta-analyses, and other evidence conducted on human subjects that were published since 2015 in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. STRUCTURE – The focus of this clinical practice guideline is to create a living, working document that provides current knowledge in the field of cardiovascular-kidney-metabolic syndrome aimed at all practicing cardiologists, endocrinologists, nephrologists, and primary care and specialty clinicians who manage these patients.",

keywords = "AHA Scientific Statements, MASLD, atherosclerosis, atrial fibrillation, blood pressure/hypertension, cardiovascular disease, cardiovascular kidney metabolic, coronary disease, diabetes, diagnosis, heart failure, kidney disease(s), chronic, management, cardiovascular kidney metabolic, metabolic syndrome, overweight/obesity, peripheral artery disease, renal insufficiency, risk factors, screenings, secondary prevention, venous thromboembolism, weight loss",

author = "C. Ndumele and Ndumele, \{Chiadi E.\} and Fatima Rodriguez and Dixon, \{Dave L.\} and Khan, \{Sadiya S.\} and Debabrata Mukherjee and Mandeep Bajaj and Sripal Bangalore and Biykem Bozkurt and Khadijah Breathett and Clarke, \{Shoa L.\} and \{de Boer\}, \{Ian H.\} and Ellison, \{David H.\} and Evangelista, \{Lorraine S.\} and Heffron, \{Sean P.\} and Kazi, \{Dhruv S.\} and Ambar Kulshreshtha and Ildiko Lingvay and \{Low Wang\}, \{Cecilia C.\} and Mercado, \{Claudia A.\} and Morton, \{John Maga{\~n}a\} and Neeland, \{Ian J.\} and Neha Pagidipati and Powell-Wiley, \{Tiffany M.\} and Janani Rangaswami and Goutham Rao and Nosheen Reza and Anum Saeed and \{St. Peter\}, Wendy and Starks, \{J. Bradley\} and Madeline Sterling and Talbot, \{Amy W.\} and Tran, \{Andrew H.\} and Tuttle, \{Katherine R.\} and VanWagner, \{Lisa B.\} and Vest, \{Amanda R.\} and Virani, \{Salim S.\} and Nicole Bhave and Amit Khera and Alexander, \{Kevin M.\} and Bailey, \{Alison L.\} and Bonaca, \{Marc P.\} and Chang, \{Tara I.\} and Cornelio, \{Cyrille K.\} and Costanzo, \{Maria Rosa\} and Colette DeJong and Adam DeVore and Gee, \{Patrick O.\} and Green, \{Beverly B.\} and Green, \{Jennifer B.\} and Scott Kahan and Anuradha Lala and Melissa Magwire and Michael Miller and Katie Moegenberg and Elif Oral and Orringer, \{Carl E.\} and Patel, \{Kershaw V.\} and Sonali Patel and Reusch, \{Jane E.B.\} and Philip Schauer and Weiner, \{Daniel E.\}",

note = "Publisher Copyright: {\textcopyright} 2026 by the American College of Cardiology Foundation and the American Heart Association, Inc.",

year = "2026",

doi = "10.1161/CIR.0000000000001453",

language = "English",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams and Wilkins",

}

Ndumele, C, Ndumele, CE, Rodriguez, F, Dixon, DL, Khan, SS, Mukherjee, D, Bajaj, M, Bangalore, S, Bozkurt, B, Breathett, K, Clarke, SL, de Boer, IH, Ellison, DH, Evangelista, LS, Heffron, SP, Kazi, DS, Kulshreshtha, A, Lingvay, I, Low Wang, CC, Mercado, CA, Morton, JM, Neeland, IJ, Pagidipati, N, Powell-Wiley, TM, Rangaswami, J, Rao, G, Reza, N, Saeed, A, St. Peter, W, Starks, JB, Sterling, M, Talbot, AW, Tran, AH, Tuttle, KR, VanWagner, LB, Vest, AR, Virani, SS, Bhave, N, Khera, A, Alexander, KM, Bailey, AL, Bonaca, MP, Chang, TI, Cornelio, CK, Costanzo, MR, DeJong, C, DeVore, A, Gee, PO, Green, BB, Green, JB, Kahan, S, Lala, A, Magwire, M, Miller, M, Moegenberg, K, Oral, E, Orringer, CE, Patel, KV, Patel, S, Reusch, JEB, Schauer, P & Weiner, DE 2026, '2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines', Circulation. https://doi.org/10.1161/CIR.0000000000001453

2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. / Ndumele, C.; Ndumele, Chiadi E.; Rodriguez, Fatima et al.
In: Circulation, 2026.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome

T2 - A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

AU - Ndumele, C.

AU - Ndumele, Chiadi E.

AU - Rodriguez, Fatima

AU - Dixon, Dave L.

AU - Khan, Sadiya S.

AU - Mukherjee, Debabrata

AU - Bajaj, Mandeep

AU - Bangalore, Sripal

AU - Bozkurt, Biykem

AU - Breathett, Khadijah

AU - Clarke, Shoa L.

AU - de Boer, Ian H.

AU - Ellison, David H.

AU - Evangelista, Lorraine S.

AU - Heffron, Sean P.

AU - Kazi, Dhruv S.

AU - Kulshreshtha, Ambar

AU - Lingvay, Ildiko

AU - Low Wang, Cecilia C.

AU - Mercado, Claudia A.

AU - Morton, John Magaña

AU - Neeland, Ian J.

AU - Pagidipati, Neha

AU - Powell-Wiley, Tiffany M.

AU - Rangaswami, Janani

AU - Rao, Goutham

AU - Reza, Nosheen

AU - Saeed, Anum

AU - St. Peter, Wendy

AU - Starks, J. Bradley

AU - Sterling, Madeline

AU - Talbot, Amy W.

AU - Tran, Andrew H.

AU - Tuttle, Katherine R.

AU - VanWagner, Lisa B.

AU - Vest, Amanda R.

AU - Virani, Salim S.

AU - Bhave, Nicole

AU - Khera, Amit

AU - Alexander, Kevin M.

AU - Bailey, Alison L.

AU - Bonaca, Marc P.

AU - Chang, Tara I.

AU - Cornelio, Cyrille K.

AU - Costanzo, Maria Rosa

AU - DeJong, Colette

AU - DeVore, Adam

AU - Gee, Patrick O.

AU - Green, Beverly B.

AU - Green, Jennifer B.

AU - Kahan, Scott

AU - Lala, Anuradha

AU - Magwire, Melissa

AU - Miller, Michael

AU - Moegenberg, Katie

AU - Oral, Elif

AU - Orringer, Carl E.

AU - Patel, Kershaw V.

AU - Patel, Sonali

AU - Reusch, Jane E.B.

AU - Schauer, Philip

AU - Weiner, Daniel E.

PY - 2026

Y1 - 2026

N2 - AIM – The “2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome” retires, replaces, and expands upon the “2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults.” The primary intended audience for this guideline is clinicians who care for patients across the spectrum of cardiovascular-kidney-metabolic syndrome, an interrelated condition characterized by the interconnections among metabolic risk factors (including obesity and type 2 diabetes), chronic kidney disease, and cardiovascular disease. METHODS – A comprehensive literature search was conducted from October 29, 2024, to April 14, 2025, to identify clinical studies, systematic reviews and meta-analyses, and other evidence conducted on human subjects that were published since 2015 in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. STRUCTURE – The focus of this clinical practice guideline is to create a living, working document that provides current knowledge in the field of cardiovascular-kidney-metabolic syndrome aimed at all practicing cardiologists, endocrinologists, nephrologists, and primary care and specialty clinicians who manage these patients.

AB - AIM – The “2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome” retires, replaces, and expands upon the “2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults.” The primary intended audience for this guideline is clinicians who care for patients across the spectrum of cardiovascular-kidney-metabolic syndrome, an interrelated condition characterized by the interconnections among metabolic risk factors (including obesity and type 2 diabetes), chronic kidney disease, and cardiovascular disease. METHODS – A comprehensive literature search was conducted from October 29, 2024, to April 14, 2025, to identify clinical studies, systematic reviews and meta-analyses, and other evidence conducted on human subjects that were published since 2015 in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. STRUCTURE – The focus of this clinical practice guideline is to create a living, working document that provides current knowledge in the field of cardiovascular-kidney-metabolic syndrome aimed at all practicing cardiologists, endocrinologists, nephrologists, and primary care and specialty clinicians who manage these patients.

KW - AHA Scientific Statements

KW - MASLD

KW - atherosclerosis

KW - atrial fibrillation

KW - blood pressure/hypertension

KW - cardiovascular disease

KW - cardiovascular kidney metabolic

KW - coronary disease

KW - diabetes

KW - diagnosis

KW - heart failure

KW - kidney disease(s), chronic

KW - management, cardiovascular kidney metabolic

KW - metabolic syndrome

KW - overweight/obesity

KW - peripheral artery disease

KW - renal insufficiency

KW - risk factors

KW - screenings

KW - secondary prevention

KW - venous thromboembolism

KW - weight loss

UR - https://www.scopus.com/pages/publications/105044474988

U2 - 10.1161/CIR.0000000000001453

DO - 10.1161/CIR.0000000000001453

M3 - Review article

C2 - 42263157

AN - SCOPUS:105044474988

SN - 0009-7322

JO - Circulation

JF - Circulation

ER -

Ndumele C, Ndumele CE, Rodriguez F, Dixon DL, Khan SS, Mukherjee D et al. 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026. doi: 10.1161/CIR.0000000000001453

2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Abstract

Keywords

Access to Document

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