TY - JOUR
T1 - A biomedical open knowledge network harnesses the power of AI to understand deep human biology
AU - Baranzini, Sergio E.
AU - Börner, Katy
AU - Morris, John
AU - Nelson, Charlotte A.
AU - Soman, Karthik
AU - Schleimer, Erica
AU - Keiser, Michael
AU - Musen, Mark
AU - Pearce, Roger
AU - Reza, Tahsin
AU - Smith, Brett
AU - Herr, Bruce W.
AU - Oskotsky, Boris
AU - Rizk-Jackson, Angela
AU - Rankin, Katherine P.
AU - Sanders, Stephan J.
AU - Bove, Riley
AU - Rose, Peter W.
AU - Israni, Sharat
AU - Huang, Sui
N1 - Publisher Copyright:
© 2022 The Authors. AI Magazine published by Wiley Periodicals LLC on behalf of the Association for the Advancement of Artificial Intelligence.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Knowledge representation and reasoning (KR&R) has been successfully implemented in many fields to enable computers to solve complex problems with AI methods. However, its application to biomedicine has been lagging in part due to the daunting complexity of molecular and cellular pathways that govern human physiology and pathology. In this article, we describe concrete uses of Scalable PrecisiOn Medicine Knowledge Engine (SPOKE), an open knowledge network that connects curated information from thirty-seven specialized and human-curated databases into a single property graph, with 3 million nodes and 15 million edges to date. Applications discussed in this article include drug discovery, COVID-19 research and chronic disease diagnosis, and management.
AB - Knowledge representation and reasoning (KR&R) has been successfully implemented in many fields to enable computers to solve complex problems with AI methods. However, its application to biomedicine has been lagging in part due to the daunting complexity of molecular and cellular pathways that govern human physiology and pathology. In this article, we describe concrete uses of Scalable PrecisiOn Medicine Knowledge Engine (SPOKE), an open knowledge network that connects curated information from thirty-seven specialized and human-curated databases into a single property graph, with 3 million nodes and 15 million edges to date. Applications discussed in this article include drug discovery, COVID-19 research and chronic disease diagnosis, and management.
UR - https://www.scopus.com/pages/publications/85134187783
U2 - 10.1002/aaai.12037
DO - 10.1002/aaai.12037
M3 - Article
C2 - 36093122
AN - SCOPUS:85134187783
SN - 0738-4602
VL - 43
SP - 46
EP - 58
JO - AI Magazine
JF - AI Magazine
IS - 1
ER -