Abstract CT053: Intratumoral coxsackievirus A21 increases immune-cell infiltrates and upregulates immune-checkpoint molecules in the tumor microenvironment of advanced melanoma patients: phase II CALM extension study

Robert Andtbacka; Brendan Curti; Sigrun Hallmeyer; Zipei Peng; Christopher Paustian; Carlo Bifulco; Bernard Fox; Mark Grose; Darren R. Shafren

doi:10.1158/1538-7445.AM2016-CT053

Abstract CT053: Intratumoral coxsackievirus A21 increases immune-cell infiltrates and upregulates immune-checkpoint molecules in the tumor microenvironment of advanced melanoma patients: phase II CALM extension study

Robert Andtbacka
, Brendan Curti
, Sigrun Hallmeyer
, Zipei Peng
, Christopher Paustian
, Carlo Bifulco
, Bernard Fox
, Mark Grose
, Darren R. Shafren

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Cancer Research
Volume	76
DOIs	https://doi.org/10.1158/1538-7445.AM2016-CT053
State	Published - Jul 15 2016

Disciplines

Immunology and Infectious Disease
Medicine and Health Sciences

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10.1158/1538-7445.AM2016-CT053License: Unspecified

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Andtbacka, R., Curti, B., Hallmeyer, S., Peng, Z., Paustian, C., Bifulco, C., Fox, B., Grose, M., & Shafren, D. R. (2016). Abstract CT053: Intratumoral coxsackievirus A21 increases immune-cell infiltrates and upregulates immune-checkpoint molecules in the tumor microenvironment of advanced melanoma patients: phase II CALM extension study. Cancer Research, 76. https://doi.org/10.1158/1538-7445.AM2016-CT053

@article{98d4e552737f4737b1d304adc0c7264a,

title = "Abstract CT053: Intratumoral coxsackievirus A21 increases immune-cell infiltrates and upregulates immune-checkpoint molecules in the tumor microenvironment of advanced melanoma patients: phase II CALM extension study",

author = "Robert Andtbacka and Brendan Curti and Sigrun Hallmeyer and Zipei Peng and Christopher Paustian and Carlo Bifulco and Bernard Fox and Mark Grose and Shafren, \{Darren R.\}",

note = "Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA Background: CAVATAK, an oncolytic immunotherapy, is a bio-selected oncolytic strain of Coxsackievirus A21 (CVA21). Following intratumoral (IT) injection, CVA21 preferentially infects ICAM-1 expressing tumor cells, resulting in viral replication, cell lysis, and a systemic anti-tumor immune response.",

year = "2016",

month = jul,

day = "15",

doi = "10.1158/1538-7445.AM2016-CT053",

language = "American English",

volume = "76",

journal = "Cancer Research",

}

Andtbacka, R, Curti, B, Hallmeyer, S, Peng, Z, Paustian, C, Bifulco, C, Fox, B, Grose, M & Shafren, DR 2016, 'Abstract CT053: Intratumoral coxsackievirus A21 increases immune-cell infiltrates and upregulates immune-checkpoint molecules in the tumor microenvironment of advanced melanoma patients: phase II CALM extension study', Cancer Research, vol. 76. https://doi.org/10.1158/1538-7445.AM2016-CT053

Abstract CT053: Intratumoral coxsackievirus A21 increases immune-cell infiltrates and upregulates immune-checkpoint molecules in the tumor microenvironment of advanced melanoma patients: phase II CALM extension study. / Andtbacka, Robert; Curti, Brendan; Hallmeyer, Sigrun et al.
In: Cancer Research, Vol. 76, 15.07.2016.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Abstract CT053: Intratumoral coxsackievirus A21 increases immune-cell infiltrates and upregulates immune-checkpoint molecules in the tumor microenvironment of advanced melanoma patients: phase II CALM extension study

AU - Andtbacka, Robert

AU - Curti, Brendan

AU - Hallmeyer, Sigrun

AU - Peng, Zipei

AU - Paustian, Christopher

AU - Bifulco, Carlo

AU - Fox, Bernard

AU - Grose, Mark

AU - Shafren, Darren R.

N1 - Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA Background: CAVATAK, an oncolytic immunotherapy, is a bio-selected oncolytic strain of Coxsackievirus A21 (CVA21). Following intratumoral (IT) injection, CVA21 preferentially infects ICAM-1 expressing tumor cells, resulting in viral replication, cell lysis, and a systemic anti-tumor immune response.

PY - 2016/7/15

Y1 - 2016/7/15

UR - https://cancerres.aacrjournals.org/content/76/14_Supplement/CT053

U2 - 10.1158/1538-7445.AM2016-CT053

DO - 10.1158/1538-7445.AM2016-CT053

M3 - Article

VL - 76

JO - Cancer Research

JF - Cancer Research

ER -

Abstract CT053: Intratumoral coxsackievirus A21 increases immune-cell infiltrates and upregulates immune-checkpoint molecules in the tumor microenvironment of advanced melanoma patients: phase II CALM extension study

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