Adaptive trials in the neoadjuvant setting: a model to safely tailor care while accelerating drug development

Douglas Yee; Tufia Haddad; Kathy Albain; Anna Barker; Christopher Benz; Judy Boughey; Meredith Buxton; Amy Jo Chien; Angela DeMichele; David Dilts; Anthony Elias; Paul Haluska; Michael Hogarth; Alan Hu; Nola Hytlon; Henry G Kaplan; Gary G Kelloff; Qamar Khan; Julie Lang; Brian Leyland-Jones; Minetta Liu; Rita Nanda; Donald Northfelt; Olufunmilayo I Olopade; John Park; Barbara Parker; David Parkinson; Sonia Pearson-White; Jane Perlmutter; Lajos Pusztai; Fraser Symmans; Hope Rugo; Debu Tripathy; Anne Wallace; David Wholley; Laura Van't Veer; Donald A Berry; Laura Esserman

doi:10.1200/JCO.2012.44.1022

Adaptive trials in the neoadjuvant setting: a model to safely tailor care while accelerating drug development

Douglas Yee
, Tufia Haddad
, Kathy Albain
, Anna Barker
, Christopher Benz
, Judy Boughey
, Meredith Buxton
, Amy Jo Chien
, Angela DeMichele
, David Dilts
, Anthony Elias
, Paul Haluska
, Michael Hogarth
, Alan Hu
, Nola Hytlon
, Henry G Kaplan
, Gary G Kelloff
, Qamar Khan
, Julie Lang
, Brian Leyland-Jones

Minetta Liu, Rita Nanda, Donald Northfelt, Olufunmilayo I Olopade, John Park, Barbara Parker, David Parkinson, Sonia Pearson-White, Jane Perlmutter, Lajos Pusztai, Fraser Symmans, Hope Rugo, Debu Tripathy, Anne Wallace, David Wholley, Laura Van't Veer, Donald A Berry, Laura Esserman

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	4584-6; author reply 4588-9
Journal	Journal of Clinical Oncology
Volume	30
Issue number	36
DOIs	https://doi.org/10.1200/JCO.2012.44.1022
State	Published - Nov 20 2012

Keywords

Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Breast Neoplasms/therapy
Carcinoma in Situ/therapy
Carcinoma, Ductal, Breast/therapy
Female
Humans
Mastectomy
Neoadjuvant Therapy

Access to Document

10.1200/JCO.2012.44.1022

Cite this

Yee, D., Haddad, T., Albain, K., Barker, A., Benz, C., Boughey, J., Buxton, M., Chien, A. J., DeMichele, A., Dilts, D., Elias, A., Haluska, P., Hogarth, M., Hu, A., Hytlon, N., Kaplan, H. G., Kelloff, G. G., Khan, Q., Lang, J., ... Esserman, L. (2012). Adaptive trials in the neoadjuvant setting: a model to safely tailor care while accelerating drug development. Journal of Clinical Oncology, 30(36), 4584-6; author reply 4588-9. https://doi.org/10.1200/JCO.2012.44.1022

@article{d6727404ab6c440a9fa5dd12048721d9,

title = "Adaptive trials in the neoadjuvant setting: a model to safely tailor care while accelerating drug development",

keywords = "Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Breast Neoplasms/therapy, Carcinoma in Situ/therapy, Carcinoma, Ductal, Breast/therapy, Female, Humans, Mastectomy, Neoadjuvant Therapy",

author = "Douglas Yee and Tufia Haddad and Kathy Albain and Anna Barker and Christopher Benz and Judy Boughey and Meredith Buxton and Chien, \{Amy Jo\} and Angela DeMichele and David Dilts and Anthony Elias and Paul Haluska and Michael Hogarth and Alan Hu and Nola Hytlon and Kaplan, \{Henry G\} and Kelloff, \{Gary G\} and Qamar Khan and Julie Lang and Brian Leyland-Jones and Minetta Liu and Rita Nanda and Donald Northfelt and Olopade, \{Olufunmilayo I\} and John Park and Barbara Parker and David Parkinson and Sonia Pearson-White and Jane Perlmutter and Lajos Pusztai and Fraser Symmans and Hope Rugo and Debu Tripathy and Anne Wallace and David Wholley and \{Van't Veer\}, Laura and Berry, \{Donald A\} and Laura Esserman",

year = "2012",

month = nov,

day = "20",

doi = "10.1200/JCO.2012.44.1022",

language = "English",

volume = "30",

pages = "4584--6; author reply 4588--9",

journal = "Journal of Clinical Oncology",

issn = "0732-183X",

publisher = "Lippincott Williams and Wilkins",

number = "36",

}

Yee, D, Haddad, T, Albain, K, Barker, A, Benz, C, Boughey, J, Buxton, M, Chien, AJ, DeMichele, A, Dilts, D, Elias, A, Haluska, P, Hogarth, M, Hu, A, Hytlon, N, Kaplan, HG, Kelloff, GG, Khan, Q, Lang, J, Leyland-Jones, B, Liu, M, Nanda, R, Northfelt, D, Olopade, OI, Park, J, Parker, B, Parkinson, D, Pearson-White, S, Perlmutter, J, Pusztai, L, Symmans, F, Rugo, H, Tripathy, D, Wallace, A, Wholley, D, Van't Veer, L, Berry, DA & Esserman, L 2012, 'Adaptive trials in the neoadjuvant setting: a model to safely tailor care while accelerating drug development', Journal of Clinical Oncology, vol. 30, no. 36, pp. 4584-6; author reply 4588-9. https://doi.org/10.1200/JCO.2012.44.1022

TY - JOUR

T1 - Adaptive trials in the neoadjuvant setting

T2 - a model to safely tailor care while accelerating drug development

AU - Yee, Douglas

AU - Haddad, Tufia

AU - Albain, Kathy

AU - Barker, Anna

AU - Benz, Christopher

AU - Boughey, Judy

AU - Buxton, Meredith

AU - Chien, Amy Jo

AU - DeMichele, Angela

AU - Dilts, David

AU - Elias, Anthony

AU - Haluska, Paul

AU - Hogarth, Michael

AU - Hu, Alan

AU - Hytlon, Nola

AU - Kaplan, Henry G

AU - Kelloff, Gary G

AU - Khan, Qamar

AU - Lang, Julie

AU - Leyland-Jones, Brian

AU - Liu, Minetta

AU - Nanda, Rita

AU - Northfelt, Donald

AU - Olopade, Olufunmilayo I

AU - Park, John

AU - Parker, Barbara

AU - Parkinson, David

AU - Pearson-White, Sonia

AU - Perlmutter, Jane

AU - Pusztai, Lajos

AU - Symmans, Fraser

AU - Rugo, Hope

AU - Tripathy, Debu

AU - Wallace, Anne

AU - Wholley, David

AU - Van't Veer, Laura

AU - Berry, Donald A

AU - Esserman, Laura

PY - 2012/11/20

Y1 - 2012/11/20

KW - Antineoplastic Combined Chemotherapy Protocols/therapeutic use

KW - Breast Neoplasms/therapy

KW - Carcinoma in Situ/therapy

KW - Carcinoma, Ductal, Breast/therapy

KW - Female

KW - Humans

KW - Mastectomy

KW - Neoadjuvant Therapy

U2 - 10.1200/JCO.2012.44.1022

DO - 10.1200/JCO.2012.44.1022

M3 - Article

C2 - 23169510

SN - 0732-183X

VL - 30

SP - 4584-6; author reply 4588-9

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

IS - 36

ER -