Approach to a Patient with Elevated Serum Alkaline Phosphatase

Asma Siddique; Kris V. Kowdley

doi:10.1016/j.cld.2012.03.012

Approach to a Patient with Elevated Serum Alkaline Phosphatase

Asma Siddique
, Kris V. Kowdley

Research output: Contribution to journal › Review article › peer-review

95 Scopus citations

Abstract

Cholestasis develops either from a defect in bile synthesis, impairment in bile secretion, or obstruction to bile flow, and is characterized by an elevated serum alkaline phosphatase and gamma-glutamyltransferase disproportionate to elevation of aminotransferase enzymes. Key elements to the diagnostic workup include visualization of the biliary tree by cholangiography and evaluation of liver histology. The hope is that recent advances in understanding the genetic factors and immune mechanisms involved in the pathogenesis of cholestasis will lead to newer therapeutic interventions in the treatment of these diseases.

Original language	English
Pages (from-to)	199-229
Number of pages	31
Journal	Clinics in Liver Disease
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.cld.2012.03.012
State	Published - May 2012

Keywords

Bile
Cholestasis
Cirrhosis
Liver

Access to Document

10.1016/j.cld.2012.03.012

Cite this

@article{9b92562c1b564e2089bd7f600e021372,

title = "Approach to a Patient with Elevated Serum Alkaline Phosphatase",

abstract = "Cholestasis develops either from a defect in bile synthesis, impairment in bile secretion, or obstruction to bile flow, and is characterized by an elevated serum alkaline phosphatase and gamma-glutamyltransferase disproportionate to elevation of aminotransferase enzymes. Key elements to the diagnostic workup include visualization of the biliary tree by cholangiography and evaluation of liver histology. The hope is that recent advances in understanding the genetic factors and immune mechanisms involved in the pathogenesis of cholestasis will lead to newer therapeutic interventions in the treatment of these diseases.",

keywords = "Bile, Cholestasis, Cirrhosis, Liver",

author = "Asma Siddique and Kowdley, \{Kris V.\}",

note = "Funding Information: This work was supported in part by NIH grant DK02957 to Kris V. Kowdley. ",

year = "2012",

month = may,

doi = "10.1016/j.cld.2012.03.012",

language = "English",

volume = "16",

pages = "199--229",

journal = "Clinics in Liver Disease",

issn = "1089-3261",

publisher = "W.B. Saunders",

number = "2",

}

TY - JOUR

T1 - Approach to a Patient with Elevated Serum Alkaline Phosphatase

AU - Siddique, Asma

AU - Kowdley, Kris V.

N1 - Funding Information: This work was supported in part by NIH grant DK02957 to Kris V. Kowdley.

PY - 2012/5

Y1 - 2012/5

N2 - Cholestasis develops either from a defect in bile synthesis, impairment in bile secretion, or obstruction to bile flow, and is characterized by an elevated serum alkaline phosphatase and gamma-glutamyltransferase disproportionate to elevation of aminotransferase enzymes. Key elements to the diagnostic workup include visualization of the biliary tree by cholangiography and evaluation of liver histology. The hope is that recent advances in understanding the genetic factors and immune mechanisms involved in the pathogenesis of cholestasis will lead to newer therapeutic interventions in the treatment of these diseases.

AB - Cholestasis develops either from a defect in bile synthesis, impairment in bile secretion, or obstruction to bile flow, and is characterized by an elevated serum alkaline phosphatase and gamma-glutamyltransferase disproportionate to elevation of aminotransferase enzymes. Key elements to the diagnostic workup include visualization of the biliary tree by cholangiography and evaluation of liver histology. The hope is that recent advances in understanding the genetic factors and immune mechanisms involved in the pathogenesis of cholestasis will lead to newer therapeutic interventions in the treatment of these diseases.

KW - Bile

KW - Cholestasis

KW - Cirrhosis

KW - Liver

UR - https://www.scopus.com/pages/publications/84860264787

U2 - 10.1016/j.cld.2012.03.012

DO - 10.1016/j.cld.2012.03.012

M3 - Review article

C2 - 22541695

AN - SCOPUS:84860264787

SN - 1089-3261

VL - 16

SP - 199

EP - 229

JO - Clinics in Liver Disease

JF - Clinics in Liver Disease

IS - 2

ER -

Approach to a Patient with Elevated Serum Alkaline Phosphatase

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this