TY - JOUR
T1 - Association of retinol binding protein 4 with risk of gestational diabetes
AU - Abetew, Dejene F.
AU - Qiu, Chunfang
AU - Fida, Neway G.
AU - Dishi, Michal
AU - Hevner, Karin
AU - Williams, Michelle A.
AU - Enquobahrie, Daniel A.
N1 - Funding Information:
The authors are very thankful to the participants of the Omega study and staff of Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA for their technical support with this research. This research was supported by awards from the National Institutes of Health ( R01HD-055566 and R01HD-32562 ). Dr. Enquobahrie was supported by a K01 award ( K01HL-103174 ).
PY - 2013/1
Y1 - 2013/1
N2 - Aim: We investigated association of maternal retinol binding protein 4 (RBP4) with risk of gestational diabetes (GDM). Methods: GDM cases (N= 173) and controls (N= 187) were selected from among participants of a cohort study of risk factors of pregnancy complications. Early pregnancy (16 weeks on average) serum RBP4 concentration was measured using an ELISA-based immunoassay. Logistic regression was used to estimate unadjusted and adjusted odds ratios (ORs/aORs) and 95% confidence intervals (95%CI). Results: Mean serum RBP4 was significantly higher among GDM cases compared with controls (47.1 vs. 41.1 μg/ml, respectively; p-value <0.05). Participants in the highest quartile for serum RBP4 had a 1.89-fold higher risk of GDM compared with participants in the lowest quartile (95%CI: 1.05-3.43). However, this relationship did not reach statistical significance after adjustment for confounders (aOR: 1.54; 95%CI: 0.82-2.90). Women who were ≥35 years old and who had high RBP4 (≥38.3 μg/ml, the median) had a 2.31-fold higher risk of GDM compared with women who were <35 years old and had low RBP4 (<38.3 μg/ml) (aOR: 2.31; 95%CI: 1.26-4.23; p-value for interaction = 0.021). Conclusion: Overall, there is modest evidence of a positive association of early pregnancy elevated RBP4 concentration with increased GDM risk, particularly among women with advanced age.
AB - Aim: We investigated association of maternal retinol binding protein 4 (RBP4) with risk of gestational diabetes (GDM). Methods: GDM cases (N= 173) and controls (N= 187) were selected from among participants of a cohort study of risk factors of pregnancy complications. Early pregnancy (16 weeks on average) serum RBP4 concentration was measured using an ELISA-based immunoassay. Logistic regression was used to estimate unadjusted and adjusted odds ratios (ORs/aORs) and 95% confidence intervals (95%CI). Results: Mean serum RBP4 was significantly higher among GDM cases compared with controls (47.1 vs. 41.1 μg/ml, respectively; p-value <0.05). Participants in the highest quartile for serum RBP4 had a 1.89-fold higher risk of GDM compared with participants in the lowest quartile (95%CI: 1.05-3.43). However, this relationship did not reach statistical significance after adjustment for confounders (aOR: 1.54; 95%CI: 0.82-2.90). Women who were ≥35 years old and who had high RBP4 (≥38.3 μg/ml, the median) had a 2.31-fold higher risk of GDM compared with women who were <35 years old and had low RBP4 (<38.3 μg/ml) (aOR: 2.31; 95%CI: 1.26-4.23; p-value for interaction = 0.021). Conclusion: Overall, there is modest evidence of a positive association of early pregnancy elevated RBP4 concentration with increased GDM risk, particularly among women with advanced age.
KW - Gestational diabetes
KW - Maternal age
KW - Pregnancy
KW - Retinol binding protein 4
UR - https://www.scopus.com/pages/publications/84870999045
U2 - 10.1016/j.diabres.2012.10.023
DO - 10.1016/j.diabres.2012.10.023
M3 - Article
C2 - 23153527
AN - SCOPUS:84870999045
SN - 0168-8227
VL - 99
SP - 48
EP - 53
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 1
ER -