Boosting NAD Level Suppresses Inflammatory Activation of PBMC in Heart Failure.

Bo Zhou; Dennis D. Wang; Yanhua Qiu; Sophia Airhart; Yaxin Liu; April Stempien-Otero; Kevin D. O’Brien; Rong Tian.

doi:10.1172/JCI138538

Boosting NAD Level Suppresses Inflammatory Activation of PBMC in Heart Failure.

Bo Zhou, Dennis D. Wang, Yanhua Qiu, Sophia Airhart, Yaxin Liu, April Stempien-Otero, Kevin D. O’Brien, Rong Tian.

Center for Cardiovascular Analytics, Research and Data Science (CARDS)

Research output: Contribution to journal › Article › peer-review

133 Scopus citations

Original language	American English
Journal	Journal of Clinical Investigation
DOIs	https://doi.org/10.1172/JCI138538
State	Published - Aug 13 2020

Disciplines

Pharmacology
Medicine and Health Sciences

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10.1172/JCI138538License: Unspecified

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@article{c03da940950e4a9c9d234a33e7433742,

title = "Boosting NAD Level Suppresses Inflammatory Activation of PBMC in Heart Failure.",

author = "Bo Zhou and Wang, {Dennis D.} and Yanhua Qiu and Sophia Airhart and Yaxin Liu and April Stempien-Otero and O{\textquoteright}Brien, {Kevin D.} and Rong Tian.",

note = "Background:While mitochondria play an important role in innate immunity, the relationship between mitochondrial dysfunction and inflammation in heart failure (HF) is poorly understood. In this study we aimed to investigate the mechanistic link between mitochondrial dysfunction and inflammatory activation in peripheral blood mononuclear cells (PBMCs), and the potential anti-inflammatory effect of boosting NAD level.Methods:We compared the PBMC mitochondrial respiration of 19 hospitalized Stage D HF patients with 19 healthy participants.",

year = "2020",

month = aug,

day = "13",

doi = "10.1172/JCI138538",

language = "American English",

journal = "Journal of Clinical Investigation",

}

TY - JOUR

T1 - Boosting NAD Level Suppresses Inflammatory Activation of PBMC in Heart Failure.

AU - Zhou, Bo

AU - Wang, Dennis D.

AU - Qiu, Yanhua

AU - Airhart, Sophia

AU - Liu, Yaxin

AU - Stempien-Otero, April

AU - O’Brien, Kevin D.

AU - Tian., Rong

N1 - Background:While mitochondria play an important role in innate immunity, the relationship between mitochondrial dysfunction and inflammation in heart failure (HF) is poorly understood. In this study we aimed to investigate the mechanistic link between mitochondrial dysfunction and inflammatory activation in peripheral blood mononuclear cells (PBMCs), and the potential anti-inflammatory effect of boosting NAD level.Methods:We compared the PBMC mitochondrial respiration of 19 hospitalized Stage D HF patients with 19 healthy participants.

PY - 2020/8/13

Y1 - 2020/8/13

UR - https://www.jci.org/articles/view/138538/pdf

U2 - 10.1172/JCI138538

DO - 10.1172/JCI138538

M3 - Article

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

ER -

Boosting NAD Level Suppresses Inflammatory Activation of PBMC in Heart Failure.

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