Cancer microenvironment and genomics: evolution in process

Stanley P. Leong; Isaac P. Witz; Orit Sagi-Assif; Sivan Izraely; Jonathan Sleeman; Brian Piening; Bernard A. Fox; Carlo B. Bifulco; Rachel Martini; Lisa Newman; Melissa Davis; Lauren M. Sanders; David Haussler; Olena M. Vaske; Marlys Witte

doi:10.1007/s10585-021-10097-9

Cancer microenvironment and genomics: evolution in process

Stanley P. Leong, Isaac P. Witz, Orit Sagi-Assif, Sivan Izraely, Jonathan Sleeman, Brian Piening, Bernard A. Fox, Carlo B. Bifulco, Rachel Martini, Lisa Newman, Melissa Davis, Lauren M. Sanders, David Haussler, Olena M. Vaske, Marlys Witte

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Cancer heterogeneity is a result of genetic mutations within the cancer cells. Their proliferation is not only driven by autocrine functions but also under the influence of cancer microenvironment, which consists of normal stromal cells such as infiltrating immune cells, cancer-associated fibroblasts, endothelial cells, pericytes, vascular and lymphatic channels. The relationship between cancer cells and cancer microenvironment is a critical one and we are just on the verge to understand it on a molecular level. Cancer microenvironment may serve as a selective force to modulate cancer cells to allow them to evolve into more aggressive clones with ability to invade the lymphatic or vascular channels to spread to regional lymph nodes and distant sites. It is important to understand these steps of cancer evolution within the cancer microenvironment towards invasion so that therapeutic strategies can be developed to control or stop these processes.

Original language	English
Pages (from-to)	85-99
Number of pages	15
Journal	Clinical and Experimental Metastasis
Volume	39
Issue number	1
DOIs	https://doi.org/10.1007/s10585-021-10097-9
State	Published - Feb 2022

Keywords

Cancer evolution
Cancer heterogeneity
Cancer metastasis
Cancer microenvironment

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10.1007/s10585-021-10097-9

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title = "Cancer microenvironment and genomics: evolution in process",

abstract = "Cancer heterogeneity is a result of genetic mutations within the cancer cells. Their proliferation is not only driven by autocrine functions but also under the influence of cancer microenvironment, which consists of normal stromal cells such as infiltrating immune cells, cancer-associated fibroblasts, endothelial cells, pericytes, vascular and lymphatic channels. The relationship between cancer cells and cancer microenvironment is a critical one and we are just on the verge to understand it on a molecular level. Cancer microenvironment may serve as a selective force to modulate cancer cells to allow them to evolve into more aggressive clones with ability to invade the lymphatic or vascular channels to spread to regional lymph nodes and distant sites. It is important to understand these steps of cancer evolution within the cancer microenvironment towards invasion so that therapeutic strategies can be developed to control or stop these processes.",

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doi = "10.1007/s10585-021-10097-9",

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AU - Leong, Stanley P.

AU - Witz, Isaac P.

AU - Sagi-Assif, Orit

AU - Izraely, Sivan

AU - Sleeman, Jonathan

AU - Piening, Brian

AU - Fox, Bernard A.

AU - Bifulco, Carlo B.

AU - Martini, Rachel

AU - Newman, Lisa

AU - Davis, Melissa

AU - Sanders, Lauren M.

AU - Haussler, David

AU - Vaske, Olena M.

AU - Witte, Marlys

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N2 - Cancer heterogeneity is a result of genetic mutations within the cancer cells. Their proliferation is not only driven by autocrine functions but also under the influence of cancer microenvironment, which consists of normal stromal cells such as infiltrating immune cells, cancer-associated fibroblasts, endothelial cells, pericytes, vascular and lymphatic channels. The relationship between cancer cells and cancer microenvironment is a critical one and we are just on the verge to understand it on a molecular level. Cancer microenvironment may serve as a selective force to modulate cancer cells to allow them to evolve into more aggressive clones with ability to invade the lymphatic or vascular channels to spread to regional lymph nodes and distant sites. It is important to understand these steps of cancer evolution within the cancer microenvironment towards invasion so that therapeutic strategies can be developed to control or stop these processes.

AB - Cancer heterogeneity is a result of genetic mutations within the cancer cells. Their proliferation is not only driven by autocrine functions but also under the influence of cancer microenvironment, which consists of normal stromal cells such as infiltrating immune cells, cancer-associated fibroblasts, endothelial cells, pericytes, vascular and lymphatic channels. The relationship between cancer cells and cancer microenvironment is a critical one and we are just on the verge to understand it on a molecular level. Cancer microenvironment may serve as a selective force to modulate cancer cells to allow them to evolve into more aggressive clones with ability to invade the lymphatic or vascular channels to spread to regional lymph nodes and distant sites. It is important to understand these steps of cancer evolution within the cancer microenvironment towards invasion so that therapeutic strategies can be developed to control or stop these processes.

KW - Cancer evolution

KW - Cancer heterogeneity

KW - Cancer metastasis

KW - Cancer microenvironment

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DO - 10.1007/s10585-021-10097-9

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SP - 85

EP - 99

JO - Clinical and Experimental Metastasis

JF - Clinical and Experimental Metastasis

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Cancer microenvironment and genomics: evolution in process

Abstract

Keywords

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