CFC phaseout and advances in oral inhalers

Purpose: The purpose of the article is to review the current status of the phaseout of chlorofluorocarbons (CFCs) from orally inhaled medications and to review the new oral inhalation devices on the market or in development. Methods: Searches of Medline, Web of Science, manufacturer Web sites, and Internet search engines were conducted to find information on CFCs, inhalers, and individual products. Results: The global phaseout of CFCs must be completed by 2010. Several CFC-free inhalers have been introduced to the market, and some are still in development. Many of these have unique features from the metered-dose inhalers. The new devices all seem to be effective, though some patients prefer one inhalation device to another. Conclusion: The new devices not only are CFC-free but also offer potential advantages in medication administration. The best inhaler for a patient depends on each individual's unique needs.