Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001

Terese Catherine Hammond; Raymond C. Lee; Bryan Oronsky; Tony R. Reid; Scott Caroen; Tiffany M. Juarez; Jaya Gill; Annie Heng; Santosh Kesari

doi:10.2147/IMCRJ.S389690

Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001

Terese Catherine Hammond, Raymond C. Lee, Bryan Oronsky, Tony R. Reid, Scott Caroen, Tiffany M. Juarez, Jaya Gill, Annie Heng, Santosh Kesari

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Two critically ill COVID-19 infected patients, who had exhausted all available treatment options, were treated with the small-molecule RRx-001 with subsequent improvement. RRx-001, a first-in-class small molecule with anti-inflammatory, vascular normalizing and macrophage-repolarizing properties, has been safely administered 300+ patients in clinical trials. This is the first report of RRx-001 treatment of COVID-19.

Original language	English
Pages (from-to)	735-738
Number of pages	4
Journal	International Medical Case Reports Journal
Volume	15
DOIs	https://doi.org/10.2147/IMCRJ.S389690
State	Published - 2022

Keywords

ARDS
COVID-19
RRx-001
SARS-CoV-2
critical care
nitric oxide
viral diseases

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10.2147/IMCRJ.S389690

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title = "Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001",

abstract = "Two critically ill COVID-19 infected patients, who had exhausted all available treatment options, were treated with the small-molecule RRx-001 with subsequent improvement. RRx-001, a first-in-class small molecule with anti-inflammatory, vascular normalizing and macrophage-repolarizing properties, has been safely administered 300+ patients in clinical trials. This is the first report of RRx-001 treatment of COVID-19.",

keywords = "ARDS, COVID-19, RRx-001, SARS-CoV-2, critical care, nitric oxide, viral diseases",

author = "Hammond, {Terese Catherine} and Lee, {Raymond C.} and Bryan Oronsky and Reid, {Tony R.} and Scott Caroen and Juarez, {Tiffany M.} and Jaya Gill and Annie Heng and Santosh Kesari",

note = "Publisher Copyright: {\textcopyright} 2022 Hammond et al.",

year = "2022",

doi = "10.2147/IMCRJ.S389690",

language = "English",

volume = "15",

pages = "735--738",

journal = "International Medical Case Reports Journal",

issn = "1179-142X",

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T1 - Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001

AU - Hammond, Terese Catherine

AU - Lee, Raymond C.

AU - Oronsky, Bryan

AU - Reid, Tony R.

AU - Caroen, Scott

AU - Juarez, Tiffany M.

AU - Gill, Jaya

AU - Heng, Annie

AU - Kesari, Santosh

PY - 2022

Y1 - 2022

N2 - Two critically ill COVID-19 infected patients, who had exhausted all available treatment options, were treated with the small-molecule RRx-001 with subsequent improvement. RRx-001, a first-in-class small molecule with anti-inflammatory, vascular normalizing and macrophage-repolarizing properties, has been safely administered 300+ patients in clinical trials. This is the first report of RRx-001 treatment of COVID-19.

AB - Two critically ill COVID-19 infected patients, who had exhausted all available treatment options, were treated with the small-molecule RRx-001 with subsequent improvement. RRx-001, a first-in-class small molecule with anti-inflammatory, vascular normalizing and macrophage-repolarizing properties, has been safely administered 300+ patients in clinical trials. This is the first report of RRx-001 treatment of COVID-19.

KW - ARDS

KW - COVID-19

KW - RRx-001

KW - SARS-CoV-2

KW - critical care

KW - nitric oxide

KW - viral diseases

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SN - 1179-142X

VL - 15

SP - 735

EP - 738

JO - International Medical Case Reports Journal

JF - International Medical Case Reports Journal

ER -

Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001

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