Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study.

Bernhard Mlecnik; Toshihiko Torigoe; Gabriela Bindea; Boryana Popivanova; Mingli Xu; Tomonobu Fujita; Shoichi Hazama; Nobuaki Suzuki; Hiroaki Nagano; Kiyotaka Okuno; Yoshihiko Hirohashi; Tomohisa Furuhata; Ichiro Takemasa; Prabhudas Patel; Hemangini Vora; Birva Shah; Patel Jayendrakumar B; Rajvik Kruti N; Pandya Shashank J; Shukla Shilin N; Yili Wang; Guanjun Zhang; Takayuki Yoshino; Hiroya Taniguchi; Carlo Bifulco; Alessandro Lugli; Jiun-Kae Jack Lee; Inti Zlobec; Rau Tilman T; Berger Martin D; Nagtegaal Iris D; Elisa Vink-Börger; Arndt Hartmann; Geppert Carol I; Julie Kolwelter; Susanne Merkel; Robert Grützmann; Marc Van den Eynde; Anne Jouret-Mourin; Alex Kartheuser; Daniel Léonard; Christophe Remue; Julia Wang; Prashant Bavi; Roehrl Michael H A; Ohashi Pamela S; Nguyen Linh T; SeongJun Han; MacGregor Heather L; Sara Hafezi-Bakhtiari; Wouters Bradly G; Masucci Giuseppe V; Emilia Andersson; Eva Zavadova; Michal Vocka; Jan Spacek; Lubos Petruzelka; Bohuslav Konopasek; Pavel Dundr; Helena Skalova; Kristyna Nemejcova; Gerardo Botti; Fabiana Tatangelo; Paolo Delrio; Gennaro Ciliberto; Michele Maio; Luigi Laghi; Fabio Grizzi; Florence Marliot; Tessa Fredriksen; Bénédicte Buttard; Lucie Lafontaine; Pauline Maby; Amine Majdi; Assia Hijazi; Carine El Sissy; Amos Kirilovsky; Anne Berger; Christine Lagorce; Christopher Paustian; Carmen Ballesteros-Merino; Jeroen Dijkstra; Carlijn Van de Water; Shannon van Lent-van Vliet; Nikki Knijn; Ana-Maria Mușină; Dragos-Viorel Scripcariu; Marincola Francesco M; Ascierto Paolo A; Fox Bernard A; Franck Pagès; Yutaka Kawakami; Jérôme Galon

Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study.

Bernhard Mlecnik, Toshihiko Torigoe, Gabriela Bindea, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Yoshihiko Hirohashi, Tomohisa Furuhata, Ichiro Takemasa, Prabhudas Patel, Hemangini Vora, Birva Shah, Patel Jayendrakumar B, Rajvik Kruti N, Pandya Shashank J, Shukla Shilin NYili Wang, Guanjun Zhang, Takayuki Yoshino, Hiroya Taniguchi, Carlo Bifulco, Alessandro Lugli, Jiun-Kae Jack Lee, Inti Zlobec, Rau Tilman T, Berger Martin D, Nagtegaal Iris D, Elisa Vink-Börger, Arndt Hartmann, Geppert Carol I, Julie Kolwelter, Susanne Merkel, Robert Grützmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Julia Wang, Prashant Bavi, Roehrl Michael H A, Ohashi Pamela S, Nguyen Linh T, SeongJun Han, MacGregor Heather L, Sara Hafezi-Bakhtiari, Wouters Bradly G, Masucci Giuseppe V, Emilia Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Florence Marliot, Tessa Fredriksen, Bénédicte Buttard, Lucie Lafontaine, Pauline Maby, Amine Majdi, Assia Hijazi, Carine El Sissy, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn Van de Water, Shannon van Lent-van Vliet, Nikki Knijn, Ana-Maria Mușină, Dragos-Viorel Scripcariu, Marincola Francesco M, Ascierto Paolo A, Fox Bernard A, Franck Pagès, Yutaka Kawakami, Jérôme Galon

Research output: Contribution to journal › Article

Abstract

BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I-III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Immunotherapy of Cancer (SITC) on 2681 patients with AJCC/UICC-TNM stages I-III CC.

METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities were quantified in the tumor and invasive margin by digital pathology. The association of Immunoscore with prognosis was evaluated for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS).

RESULTS: Immunoscore stratified Asian patients (n = 423) into different risk categories and was not impacted by age. Recurrence-free rates at 3 years were 78.5%, 85.2%, and 98.3% for a Low, Intermediate, and High Immunoscore, respectively (HR[Low-vs-High] = 7.26 (95% CI 1.75-30.19);

CONCLUSION: A High Immunoscore is significantly associated with the prolonged survival of CC patients within the Asian population.

Original language	Undefined/Unknown
Journal	Articles, Abstracts, and Reports
State	Published - Sep 6 2022

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http://digitalcommons.psjhealth.org/publications/6550

Cite this

Mlecnik, B., Torigoe, T., Bindea, G., Popivanova, B., Xu, M., Fujita, T., Hazama, S., Suzuki, N., Nagano, H., Okuno, K., Hirohashi, Y., Furuhata, T., Takemasa, I., Patel, P., Vora, H., Shah, B., Jayendrakumar B, P., Kruti N, R., Shashank J, P., ... Galon, J. (2022). Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study. Articles, Abstracts, and Reports. http://digitalcommons.psjhealth.org/publications/6550

@article{2dccddb6481d48ab9274416fc950d6fa,

title = "Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study.",

abstract = "BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I-III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Immunotherapy of Cancer (SITC) on 2681 patients with AJCC/UICC-TNM stages I-III CC. METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities were quantified in the tumor and invasive margin by digital pathology. The association of Immunoscore with prognosis was evaluated for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS). RESULTS: Immunoscore stratified Asian patients (n = 423) into different risk categories and was not impacted by age. Recurrence-free rates at 3 years were 78.5%, 85.2%, and 98.3% for a Low, Intermediate, and High Immunoscore, respectively (HR[Low-vs-High] = 7.26 (95% CI 1.75-30.19); CONCLUSION: A High Immunoscore is significantly associated with the prolonged survival of CC patients within the Asian population.",

author = "Bernhard Mlecnik and Toshihiko Torigoe and Gabriela Bindea and Boryana Popivanova and Mingli Xu and Tomonobu Fujita and Shoichi Hazama and Nobuaki Suzuki and Hiroaki Nagano and Kiyotaka Okuno and Yoshihiko Hirohashi and Tomohisa Furuhata and Ichiro Takemasa and Prabhudas Patel and Hemangini Vora and Birva Shah and {Jayendrakumar B}, Patel and {Kruti N}, Rajvik and {Shashank J}, Pandya and {Shilin N}, Shukla and Yili Wang and Guanjun Zhang and Takayuki Yoshino and Hiroya Taniguchi and Carlo Bifulco and Alessandro Lugli and Lee, {Jiun-Kae Jack} and Inti Zlobec and {Tilman T}, Rau and {Martin D}, Berger and {Iris D}, Nagtegaal and Elisa Vink-B{\"o}rger and Arndt Hartmann and {Carol I}, Geppert and Julie Kolwelter and Susanne Merkel and Robert Gr{\"u}tzmann and Eynde, {Marc Van den} and Anne Jouret-Mourin and Alex Kartheuser and Daniel L{\'e}onard and Christophe Remue and Julia Wang and Prashant Bavi and {Michael H A}, Roehrl and {Pamela S}, Ohashi and {Linh T}, Nguyen and SeongJun Han and {Heather L}, MacGregor and Sara Hafezi-Bakhtiari and {Bradly G}, Wouters and {Giuseppe V}, Masucci and Emilia Andersson and Eva Zavadova and Michal Vocka and Jan Spacek and Lubos Petruzelka and Bohuslav Konopasek and Pavel Dundr and Helena Skalova and Kristyna Nemejcova and Gerardo Botti and Fabiana Tatangelo and Paolo Delrio and Gennaro Ciliberto and Michele Maio and Luigi Laghi and Fabio Grizzi and Florence Marliot and Tessa Fredriksen and B{\'e}n{\'e}dicte Buttard and Lucie Lafontaine and Pauline Maby and Amine Majdi and Assia Hijazi and Sissy, {Carine El} and Amos Kirilovsky and Anne Berger and Christine Lagorce and Christopher Paustian and Carmen Ballesteros-Merino and Jeroen Dijkstra and Water, {Carlijn Van de} and Vliet, {Shannon van Lent-van} and Nikki Knijn and Ana-Maria Mușin{\u a} and Dragos-Viorel Scripcariu and {Francesco M}, Marincola and {Paolo A}, Ascierto and {Bernard A}, Fox and Franck Pag{\`e}s and Yutaka Kawakami and J{\'e}r{\^o}me Galon",

year = "2022",

month = sep,

day = "6",

language = "Undefined/Unknown",

journal = "Articles, Abstracts, and Reports",

}

Mlecnik, B, Torigoe, T, Bindea, G, Popivanova, B, Xu, M, Fujita, T, Hazama, S, Suzuki, N, Nagano, H, Okuno, K, Hirohashi, Y, Furuhata, T, Takemasa, I, Patel, P, Vora, H, Shah, B, Jayendrakumar B, P, Kruti N, R, Shashank J, P, Shilin N, S, Wang, Y, Zhang, G, Yoshino, T, Taniguchi, H, Bifulco, C, Lugli, A, Lee, J-KJ, Zlobec, I, Tilman T, R, Martin D, B, Iris D, N, Vink-Börger, E, Hartmann, A, Carol I, G, Kolwelter, J, Merkel, S, Grützmann, R, Eynde, MVD, Jouret-Mourin, A, Kartheuser, A, Léonard, D, Remue, C, Wang, J, Bavi, P, Michael H A, R, Pamela S, O, Linh T, N, Han, S, Heather L, M, Hafezi-Bakhtiari, S, Bradly G, W, Giuseppe V, M, Andersson, E, Zavadova, E, Vocka, M, Spacek, J, Petruzelka, L, Konopasek, B, Dundr, P, Skalova, H, Nemejcova, K, Botti, G, Tatangelo, F, Delrio, P, Ciliberto, G, Maio, M, Laghi, L, Grizzi, F, Marliot, F, Fredriksen, T, Buttard, B, Lafontaine, L, Maby, P, Majdi, A, Hijazi, A, Sissy, CE, Kirilovsky, A, Berger, A, Lagorce, C, Paustian, C, Ballesteros-Merino, C, Dijkstra, J, Water, CVD, Vliet, SVL, Knijn, N, Mușină, A-M, Scripcariu, D-V, Francesco M, M, Paolo A, A, Bernard A, F, Pagès, F, Kawakami, Y & Galon, J 2022, 'Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study.', Articles, Abstracts, and Reports. <http://digitalcommons.psjhealth.org/publications/6550>

TY - JOUR

T1 - Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study.

AU - Mlecnik, Bernhard

AU - Torigoe, Toshihiko

AU - Bindea, Gabriela

AU - Popivanova, Boryana

AU - Xu, Mingli

AU - Fujita, Tomonobu

AU - Hazama, Shoichi

AU - Suzuki, Nobuaki

AU - Nagano, Hiroaki

AU - Okuno, Kiyotaka

AU - Hirohashi, Yoshihiko

AU - Furuhata, Tomohisa

AU - Takemasa, Ichiro

AU - Patel, Prabhudas

AU - Vora, Hemangini

AU - Shah, Birva

AU - Jayendrakumar B, Patel

AU - Kruti N, Rajvik

AU - Shashank J, Pandya

AU - Shilin N, Shukla

AU - Wang, Yili

AU - Zhang, Guanjun

AU - Yoshino, Takayuki

AU - Taniguchi, Hiroya

AU - Bifulco, Carlo

AU - Lugli, Alessandro

AU - Lee, Jiun-Kae Jack

AU - Zlobec, Inti

AU - Tilman T, Rau

AU - Martin D, Berger

AU - Iris D, Nagtegaal

AU - Vink-Börger, Elisa

AU - Hartmann, Arndt

AU - Carol I, Geppert

AU - Kolwelter, Julie

AU - Merkel, Susanne

AU - Grützmann, Robert

AU - Eynde, Marc Van den

AU - Jouret-Mourin, Anne

AU - Kartheuser, Alex

AU - Léonard, Daniel

AU - Remue, Christophe

AU - Wang, Julia

AU - Bavi, Prashant

AU - Michael H A, Roehrl

AU - Pamela S, Ohashi

AU - Linh T, Nguyen

AU - Han, SeongJun

AU - Heather L, MacGregor

AU - Hafezi-Bakhtiari, Sara

AU - Bradly G, Wouters

AU - Giuseppe V, Masucci

AU - Andersson, Emilia

AU - Zavadova, Eva

AU - Vocka, Michal

AU - Spacek, Jan

AU - Petruzelka, Lubos

AU - Konopasek, Bohuslav

AU - Dundr, Pavel

AU - Skalova, Helena

AU - Nemejcova, Kristyna

AU - Botti, Gerardo

AU - Tatangelo, Fabiana

AU - Delrio, Paolo

AU - Ciliberto, Gennaro

AU - Maio, Michele

AU - Laghi, Luigi

AU - Grizzi, Fabio

AU - Marliot, Florence

AU - Fredriksen, Tessa

AU - Buttard, Bénédicte

AU - Lafontaine, Lucie

AU - Maby, Pauline

AU - Majdi, Amine

AU - Hijazi, Assia

AU - Sissy, Carine El

AU - Kirilovsky, Amos

AU - Berger, Anne

AU - Lagorce, Christine

AU - Paustian, Christopher

AU - Ballesteros-Merino, Carmen

AU - Dijkstra, Jeroen

AU - Water, Carlijn Van de

AU - Vliet, Shannon van Lent-van

AU - Knijn, Nikki

AU - Mușină, Ana-Maria

AU - Scripcariu, Dragos-Viorel

AU - Francesco M, Marincola

AU - Paolo A, Ascierto

AU - Bernard A, Fox

AU - Pagès, Franck

AU - Kawakami, Yutaka

AU - Galon, Jérôme

PY - 2022/9/6

Y1 - 2022/9/6

N2 - BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I-III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Immunotherapy of Cancer (SITC) on 2681 patients with AJCC/UICC-TNM stages I-III CC. METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities were quantified in the tumor and invasive margin by digital pathology. The association of Immunoscore with prognosis was evaluated for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS). RESULTS: Immunoscore stratified Asian patients (n = 423) into different risk categories and was not impacted by age. Recurrence-free rates at 3 years were 78.5%, 85.2%, and 98.3% for a Low, Intermediate, and High Immunoscore, respectively (HR[Low-vs-High] = 7.26 (95% CI 1.75-30.19); CONCLUSION: A High Immunoscore is significantly associated with the prolonged survival of CC patients within the Asian population.

AB - BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I-III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Immunotherapy of Cancer (SITC) on 2681 patients with AJCC/UICC-TNM stages I-III CC. METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities were quantified in the tumor and invasive margin by digital pathology. The association of Immunoscore with prognosis was evaluated for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS). RESULTS: Immunoscore stratified Asian patients (n = 423) into different risk categories and was not impacted by age. Recurrence-free rates at 3 years were 78.5%, 85.2%, and 98.3% for a Low, Intermediate, and High Immunoscore, respectively (HR[Low-vs-High] = 7.26 (95% CI 1.75-30.19); CONCLUSION: A High Immunoscore is significantly associated with the prolonged survival of CC patients within the Asian population.

M3 - Article

JO - Articles, Abstracts, and Reports

JF - Articles, Abstracts, and Reports

ER -