Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats

R. A. Parker; D. N. Gilbert; D. C. Houghton; G. A. Porter; W. M. Bennett

doi:10.1128/AAC.18.2.346

Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats

R. A. Parker
, D. N. Gilbert
, D. C. Houghton
, G. A. Porter
, W. M. Bennett

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The nephrotoxic potentials of netilmicin and tobramycin given in doses of 180 mg/kg per day for up to 14 days in rats. At this dosage, tobramycin produced mortality and significant changes in renal structure and function; netilmicin evoked minimal nephrotoxicity.

Original language	English
Pages (from-to)	346-348
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	18
Issue number	2
DOIs	https://doi.org/10.1128/AAC.18.2.346
State	Published - 1980

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title = "Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats",

abstract = "The nephrotoxic potentials of netilmicin and tobramycin given in doses of 180 mg/kg per day for up to 14 days in rats. At this dosage, tobramycin produced mortality and significant changes in renal structure and function; netilmicin evoked minimal nephrotoxicity.",

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AU - Gilbert, D. N.

AU - Houghton, D. C.

AU - Porter, G. A.

AU - Bennett, W. M.

PY - 1980

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N2 - The nephrotoxic potentials of netilmicin and tobramycin given in doses of 180 mg/kg per day for up to 14 days in rats. At this dosage, tobramycin produced mortality and significant changes in renal structure and function; netilmicin evoked minimal nephrotoxicity.

AB - The nephrotoxic potentials of netilmicin and tobramycin given in doses of 180 mg/kg per day for up to 14 days in rats. At this dosage, tobramycin produced mortality and significant changes in renal structure and function; netilmicin evoked minimal nephrotoxicity.

UR - https://www.scopus.com/pages/publications/0019132801

U2 - 10.1128/AAC.18.2.346

DO - 10.1128/AAC.18.2.346

M3 - Article

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AN - SCOPUS:0019132801

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EP - 348

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 2

ER -

Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats

Abstract

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