Cumulative suppressive index as a predictor of relapse free survival and overall survival in Human Papilloma Virus-negative oral squamous cell carcinomas with negative resection margins.

Lauren Hum; Daniel Bethmann; Zipei Feng; Shu-Ching Chang; Alexander Eckert; Carmen Ballesteros-Merino; Claudia Keschke; Matthias Kappler; Carlo Bifulco; Claudia Wickenhauser; Barbara Seliger; Bernard A Fox; Richard Bryan Bell

Cumulative suppressive index as a predictor of relapse free survival and overall survival in Human Papilloma Virus-negative oral squamous cell carcinomas with negative resection margins.

Lauren Hum, Daniel Bethmann, Zipei Feng, Shu-Ching Chang, Alexander Eckert, Carmen Ballesteros-Merino, Claudia Keschke, Matthias Kappler, Carlo Bifulco, Claudia Wickenhauser, Barbara Seliger, Bernard A Fox, Richard Bryan Bell

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: This study aimed to analyze margin status and the impact of the immune elements on recurrence in patients with oral squamous cell carcinoma (OSCC), employing a prognostic biomarker, cumulative suppressive index (CSI), which reflects FoxP3+, PD-L1+, and CD8+ cell spatial relationships in the tumor microenvironment.

METHODS: Cox proportional hazards regression was used to evaluate the interactive effect of the margin by CSI discrepancy (high, 3-4 vs low, 0-2) on recurrence free survival (RFS) and overall survival (OS) in 119 patients with stage I to IVA OSCC.

RESULTS: In cases with negative margins, multivariable analysis showed high CSI was significantly associated with worse RFS (HR = 2.59, 95% CI [1.03, 6.49], P = .04) and OS (HR = 5.49, 95% CI [1.48, 20.35], P = .01) compared to low CSI. However, high CSI was not significantly associated with recurrence in cases with positive margins.

CONCLUSIONS: Immune architecture analysis can augment our current histopathological risk assessment of margin status.

Original language	American English
Journal	Head & neck
State	Published - Oct 23 2020

Disciplines

Biostatistics
Oncology
Otolaryngology

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https://pubmed.ncbi.nlm.nih.gov/33094869

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Hum, L., Bethmann, D., Feng, Z., Chang, S.-C., Eckert, A., Ballesteros-Merino, C., Keschke, C., Kappler, M., Bifulco, C., Wickenhauser, C., Seliger, B., Fox, B. A., & Bell, R. B. (2020). Cumulative suppressive index as a predictor of relapse free survival and overall survival in Human Papilloma Virus-negative oral squamous cell carcinomas with negative resection margins. Head & neck. https://pubmed.ncbi.nlm.nih.gov/33094869

@article{e2811512974e4163b8d2baffbf3f6752,

title = "Cumulative suppressive index as a predictor of relapse free survival and overall survival in Human Papilloma Virus-negative oral squamous cell carcinomas with negative resection margins.",

abstract = " BACKGROUND: This study aimed to analyze margin status and the impact of the immune elements on recurrence in patients with oral squamous cell carcinoma (OSCC), employing a prognostic biomarker, cumulative suppressive index (CSI), which reflects FoxP3+, PD-L1+, and CD8+ cell spatial relationships in the tumor microenvironment. METHODS: Cox proportional hazards regression was used to evaluate the interactive effect of the margin by CSI discrepancy (high, 3-4 vs low, 0-2) on recurrence free survival (RFS) and overall survival (OS) in 119 patients with stage I to IVA OSCC. RESULTS: In cases with negative margins, multivariable analysis showed high CSI was significantly associated with worse RFS (HR = 2.59, 95\% CI [1.03, 6.49], P = .04) and OS (HR = 5.49, 95\% CI [1.48, 20.35], P = .01) compared to low CSI. However, high CSI was not significantly associated with recurrence in cases with positive margins. CONCLUSIONS: Immune architecture analysis can augment our current histopathological risk assessment of margin status.",

author = "Lauren Hum and Daniel Bethmann and Zipei Feng and Shu-Ching Chang and Alexander Eckert and Carmen Ballesteros-Merino and Claudia Keschke and Matthias Kappler and Carlo Bifulco and Claudia Wickenhauser and Barbara Seliger and Fox, \{Bernard A\} and Bell, \{Richard Bryan\}",

year = "2020",

month = oct,

day = "23",

language = "American English",

journal = "Head \& neck",

}

Hum, L, Bethmann, D, Feng, Z, Chang, S-C, Eckert, A, Ballesteros-Merino, C, Keschke, C, Kappler, M, Bifulco, C, Wickenhauser, C, Seliger, B, Fox, BA & Bell, RB 2020, 'Cumulative suppressive index as a predictor of relapse free survival and overall survival in Human Papilloma Virus-negative oral squamous cell carcinomas with negative resection margins.', Head & neck. <https://pubmed.ncbi.nlm.nih.gov/33094869>

TY - JOUR

T1 - Cumulative suppressive index as a predictor of relapse free survival and overall survival in Human Papilloma Virus-negative oral squamous cell carcinomas with negative resection margins.

AU - Hum, Lauren

AU - Bethmann, Daniel

AU - Feng, Zipei

AU - Chang, Shu-Ching

AU - Eckert, Alexander

AU - Ballesteros-Merino, Carmen

AU - Keschke, Claudia

AU - Kappler, Matthias

AU - Bifulco, Carlo

AU - Wickenhauser, Claudia

AU - Seliger, Barbara

AU - Fox, Bernard A

AU - Bell, Richard Bryan

PY - 2020/10/23

Y1 - 2020/10/23

N2 - BACKGROUND: This study aimed to analyze margin status and the impact of the immune elements on recurrence in patients with oral squamous cell carcinoma (OSCC), employing a prognostic biomarker, cumulative suppressive index (CSI), which reflects FoxP3+, PD-L1+, and CD8+ cell spatial relationships in the tumor microenvironment. METHODS: Cox proportional hazards regression was used to evaluate the interactive effect of the margin by CSI discrepancy (high, 3-4 vs low, 0-2) on recurrence free survival (RFS) and overall survival (OS) in 119 patients with stage I to IVA OSCC. RESULTS: In cases with negative margins, multivariable analysis showed high CSI was significantly associated with worse RFS (HR = 2.59, 95% CI [1.03, 6.49], P = .04) and OS (HR = 5.49, 95% CI [1.48, 20.35], P = .01) compared to low CSI. However, high CSI was not significantly associated with recurrence in cases with positive margins. CONCLUSIONS: Immune architecture analysis can augment our current histopathological risk assessment of margin status.

AB - BACKGROUND: This study aimed to analyze margin status and the impact of the immune elements on recurrence in patients with oral squamous cell carcinoma (OSCC), employing a prognostic biomarker, cumulative suppressive index (CSI), which reflects FoxP3+, PD-L1+, and CD8+ cell spatial relationships in the tumor microenvironment. METHODS: Cox proportional hazards regression was used to evaluate the interactive effect of the margin by CSI discrepancy (high, 3-4 vs low, 0-2) on recurrence free survival (RFS) and overall survival (OS) in 119 patients with stage I to IVA OSCC. RESULTS: In cases with negative margins, multivariable analysis showed high CSI was significantly associated with worse RFS (HR = 2.59, 95% CI [1.03, 6.49], P = .04) and OS (HR = 5.49, 95% CI [1.48, 20.35], P = .01) compared to low CSI. However, high CSI was not significantly associated with recurrence in cases with positive margins. CONCLUSIONS: Immune architecture analysis can augment our current histopathological risk assessment of margin status.

UR - https://digitalcommons.psjhealth.org/publications/3784

UR - https://pubmed.ncbi.nlm.nih.gov/33094869

M3 - Article

JO - Head & neck

JF - Head & neck

ER -

Cumulative suppressive index as a predictor of relapse free survival and overall survival in Human Papilloma Virus-negative oral squamous cell carcinomas with negative resection margins.

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