Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors.

Xiaowen Wang; Matias A Bustos; Xiaoqing Zhang; Romela Irene Ramos; Cong Tan; Yuuki Iida; Shu-Ching Chang; Matthew P Salomon; Kevin Tran; Rebecca Gentry; Yelena Kravtsova-Ivantsiv; Daniel F Kelly; Gordon B Mills; Aaron Ciechanover; Ying Mao; Dave S B Hoon

Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors.

Xiaowen Wang, Matias A Bustos, Xiaoqing Zhang, Romela Irene Ramos, Cong Tan, Yuuki Iida, Shu-Ching Chang, Matthew P Salomon, Kevin Tran, Rebecca Gentry, Yelena Kravtsova-Ivantsiv, Daniel F Kelly, Gordon B Mills, Aaron Ciechanover, Ying Mao, Dave S B Hoon

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Abstract

This study examined the role of the ubiquitin E3-ligase RNF123 in modulating downstream NF-κB1 targets in glioblastoma (GB) tumor progression. Our findings revealed an oncogenic pathway (miR-155-5p-RNF123-NF-κB1-p50-SerpinE1) that may represent a new therapeutic target pathway for GB patients with isocitrate dehydrogenase 1 and 2 (

Original language	American English
Journal	Cancers (Basel)
State	Published - Apr 27 2020

Disciplines

Oncology

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https://www.ncbi.nlm.nih.gov/pubmed/32349217

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Wang, X., Bustos, M. A., Zhang, X., Ramos, R. I., Tan, C., Iida, Y., Chang, S.-C., Salomon, M. P., Tran, K., Gentry, R., Kravtsova-Ivantsiv, Y., Kelly, D. F., Mills, G. B., Ciechanover, A., Mao, Y., & Hoon, D. S. B. (2020). Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors. Cancers (Basel). https://www.ncbi.nlm.nih.gov/pubmed/32349217

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abstract = " This study examined the role of the ubiquitin E3-ligase RNF123 in modulating downstream NF-κB1 targets in glioblastoma (GB) tumor progression. Our findings revealed an oncogenic pathway (miR-155-5p-RNF123-NF-κB1-p50-SerpinE1) that may represent a new therapeutic target pathway for GB patients with isocitrate dehydrogenase 1 and 2 (",

author = "Xiaowen Wang and Bustos, {Matias A} and Xiaoqing Zhang and Ramos, {Romela Irene} and Cong Tan and Yuuki Iida and Shu-Ching Chang and Salomon, {Matthew P} and Kevin Tran and Rebecca Gentry and Yelena Kravtsova-Ivantsiv and Kelly, {Daniel F} and Mills, {Gordon B} and Aaron Ciechanover and Ying Mao and Hoon, {Dave S B}",

year = "2020",

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language = "American English",

journal = "Cancers (Basel)",

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Wang, X, Bustos, MA, Zhang, X, Ramos, RI, Tan, C, Iida, Y, Chang, S-C, Salomon, MP, Tran, K, Gentry, R, Kravtsova-Ivantsiv, Y, Kelly, DF, Mills, GB, Ciechanover, A, Mao, Y & Hoon, DSB 2020, 'Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors.', Cancers (Basel). <https://www.ncbi.nlm.nih.gov/pubmed/32349217>

TY - JOUR

T1 - Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors.

AU - Wang, Xiaowen

AU - Bustos, Matias A

AU - Zhang, Xiaoqing

AU - Ramos, Romela Irene

AU - Tan, Cong

AU - Iida, Yuuki

AU - Chang, Shu-Ching

AU - Salomon, Matthew P

AU - Tran, Kevin

AU - Gentry, Rebecca

AU - Kravtsova-Ivantsiv, Yelena

AU - Kelly, Daniel F

AU - Mills, Gordon B

AU - Ciechanover, Aaron

AU - Mao, Ying

AU - Hoon, Dave S B

PY - 2020/4/27

Y1 - 2020/4/27

N2 - This study examined the role of the ubiquitin E3-ligase RNF123 in modulating downstream NF-κB1 targets in glioblastoma (GB) tumor progression. Our findings revealed an oncogenic pathway (miR-155-5p-RNF123-NF-κB1-p50-SerpinE1) that may represent a new therapeutic target pathway for GB patients with isocitrate dehydrogenase 1 and 2 (

AB - This study examined the role of the ubiquitin E3-ligase RNF123 in modulating downstream NF-κB1 targets in glioblastoma (GB) tumor progression. Our findings revealed an oncogenic pathway (miR-155-5p-RNF123-NF-κB1-p50-SerpinE1) that may represent a new therapeutic target pathway for GB patients with isocitrate dehydrogenase 1 and 2 (

UR - https://digitalcommons.psjhealth.org/publications/3089

UR - https://www.ncbi.nlm.nih.gov/pubmed/32349217

M3 - Article

JO - Cancers (Basel)

JF - Cancers (Basel)

ER -

Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors.

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