Duration of the protective effect of polyaspartic acid on experimental gentamicin nephrotoxicity

S. K. Swan; D. N. Gilbert; S. J. Kohlhepp; J. E. Leggett; P. W. Kohnen; W. M. Bennett

doi:10.1128/AAC.36.11.2556

Duration of the protective effect of polyaspartic acid on experimental gentamicin nephrotoxicity

S. K. Swan
, D. N. Gilbert
, S. J. Kohlhepp
, J. E. Leggett
, P. W. Kohnen
, W. M. Bennett

Research output: Contribution to journal › Comment/debate

14 Scopus citations

Abstract

It is known that daily polyaspartic acid (PAA) protects the kidney from gentamicin nephrotoxicity in a standardized rat model despite marked cortical accumulation of the aminoglycoside. The present experiments address the duration of PAA protection. When administered every other day, PAA provided functional and histologic protection against gentamicin-induced toxicity. A stepwise reduction in nephroprotection occurred as the dosage interval was prolonged.

Original language	English
Pages (from-to)	2556-2558
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	36
Issue number	11
DOIs	https://doi.org/10.1128/AAC.36.11.2556
State	Published - 1992

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title = "Duration of the protective effect of polyaspartic acid on experimental gentamicin nephrotoxicity",

abstract = "It is known that daily polyaspartic acid (PAA) protects the kidney from gentamicin nephrotoxicity in a standardized rat model despite marked cortical accumulation of the aminoglycoside. The present experiments address the duration of PAA protection. When administered every other day, PAA provided functional and histologic protection against gentamicin-induced toxicity. A stepwise reduction in nephroprotection occurred as the dosage interval was prolonged.",

author = "Swan, \{S. K.\} and Gilbert, \{D. N.\} and Kohlhepp, \{S. J.\} and Leggett, \{J. E.\} and Kohnen, \{P. W.\} and Bennett, \{W. M.\}",

year = "1992",

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language = "English",

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TY - JOUR

T1 - Duration of the protective effect of polyaspartic acid on experimental gentamicin nephrotoxicity

AU - Swan, S. K.

AU - Gilbert, D. N.

AU - Kohlhepp, S. J.

AU - Leggett, J. E.

AU - Kohnen, P. W.

AU - Bennett, W. M.

PY - 1992

Y1 - 1992

N2 - It is known that daily polyaspartic acid (PAA) protects the kidney from gentamicin nephrotoxicity in a standardized rat model despite marked cortical accumulation of the aminoglycoside. The present experiments address the duration of PAA protection. When administered every other day, PAA provided functional and histologic protection against gentamicin-induced toxicity. A stepwise reduction in nephroprotection occurred as the dosage interval was prolonged.

AB - It is known that daily polyaspartic acid (PAA) protects the kidney from gentamicin nephrotoxicity in a standardized rat model despite marked cortical accumulation of the aminoglycoside. The present experiments address the duration of PAA protection. When administered every other day, PAA provided functional and histologic protection against gentamicin-induced toxicity. A stepwise reduction in nephroprotection occurred as the dosage interval was prolonged.

UR - https://www.scopus.com/pages/publications/0026470872

U2 - 10.1128/AAC.36.11.2556

DO - 10.1128/AAC.36.11.2556

M3 - Comment/debate

C2 - 1489205

AN - SCOPUS:0026470872

SN - 0066-4804

VL - 36

SP - 2556

EP - 2558

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

Duration of the protective effect of polyaspartic acid on experimental gentamicin nephrotoxicity

Abstract

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