TY - JOUR
T1 - Effects of Age and Sex of on Response to Ursodeoxycholic Acid and Transplant-free Survival in Patients With Primary Biliary Cholangitis.
AU - Cheung, Angela C
AU - Lammers, Willem J
AU - Perez, Carla F Murillo
AU - van Buuren, Henk R
AU - Gulamhusein, Aliya
AU - Trivedi, Palak J
AU - Lazaridis, Konstantinos N
AU - Ponsioen, Cyriel Y
AU - Floreani, Annarosa
AU - Hirschfield, Gideon M
AU - Corpechot, Christophe
AU - Mayo, Marlyn J
AU - Invernizzi, Pietro
AU - Battezzati, Pier Maria
AU - Parés, Albert
AU - Nevens, Frederik
AU - Thorburn, Douglas
AU - Mason, Andrew L
AU - Carbone, Marco
AU - Kowdley, Kris V
AU - Bruns, Tony
AU - Dalekos, George N
AU - Gatselis, Nikolaos K
AU - Verhelst, Xavier
AU - Lindor, Keith D
AU - Lleo, Ana
AU - Poupon, Raoul
AU - Janssen, Harry L
AU - Hansen, Bettina E
PY - 2019/1/4
Y1 - 2019/1/4
N2 - BACKGROUND & AIMS: Primary biliary cholangitis (PBC) predominantly affects middle-aged women; there are few data on disease phenotypes and outcomes of PBC in men and younger patients. We investigated whether differences in sex and/or age at the start of ursodeoxycholic acid (UDCA) treatment are associated with response to therapy, based on biochemical markers, or differences in transplant-free survival.
METHODS: We performed a longitudinal retrospective study of 4355 adults in the Global PBC Study cohort, collected from 17 centers across Europe and North America. Patients received a diagnosis of PBC from 1961 through 2014. We evaluated the effects of sex and age on response to UDCA treatment (based on GLOBE score) and transplant-free survival using logistic regression and Cox regression analyses, respectively.
RESULTS: Male patients were older at the start of treatment (58.3±12.1 years vs 54.3±11.6 years for women; P
CONCLUSION: In longitudinal analysis of 4355 adults in the Global PBC Study, we associated patient age, but not sex, with response to UDCA treatment and transplant-free survival. Younger age at time of PBC diagnosis is associated with increased risk of treatment failure, liver transplant, and death.
AB - BACKGROUND & AIMS: Primary biliary cholangitis (PBC) predominantly affects middle-aged women; there are few data on disease phenotypes and outcomes of PBC in men and younger patients. We investigated whether differences in sex and/or age at the start of ursodeoxycholic acid (UDCA) treatment are associated with response to therapy, based on biochemical markers, or differences in transplant-free survival.
METHODS: We performed a longitudinal retrospective study of 4355 adults in the Global PBC Study cohort, collected from 17 centers across Europe and North America. Patients received a diagnosis of PBC from 1961 through 2014. We evaluated the effects of sex and age on response to UDCA treatment (based on GLOBE score) and transplant-free survival using logistic regression and Cox regression analyses, respectively.
RESULTS: Male patients were older at the start of treatment (58.3±12.1 years vs 54.3±11.6 years for women; P
CONCLUSION: In longitudinal analysis of 4355 adults in the Global PBC Study, we associated patient age, but not sex, with response to UDCA treatment and transplant-free survival. Younger age at time of PBC diagnosis is associated with increased risk of treatment failure, liver transplant, and death.
M3 - Article
JO - Articles, Abstracts, and Reports
JF - Articles, Abstracts, and Reports
ER -