Evaluation of immunotherapy (I-O)-associated immune cell (IC) dynamics and PD-L1 expression using multispectral immunohistochemistry (mIHC) and single-cell hierarchical regression modeling in early-stage breast cancer (ESBC).

Katherine Sanchez; Maritza Martel; Shu-Ching Chang; Yaping Wu; Zhaoyu Sun; Richard Nyberg; William L Redmond; Joanna Pucilowska; Shaghayegh Aliabadi-Wahle; James Imatani; Alison Katherine Conlin; Brady Bernard; Monil Shah; Dottie Wadell; Deborah R. Laxague; Lu Wen; Qiao Li; Gregory T. Wolf; Walter John Urba; David B. Page

doi:10.1200/jco.2019.37.15_suppl.e12070

Evaluation of immunotherapy (I-O)-associated immune cell (IC) dynamics and PD-L1 expression using multispectral immunohistochemistry (mIHC) and single-cell hierarchical regression modeling in early-stage breast cancer (ESBC).

Katherine Sanchez
, Maritza Martel
, Shu-Ching Chang
, Yaping Wu
, Zhaoyu Sun
, Richard Nyberg
, William L Redmond
, Joanna Pucilowska
, Shaghayegh Aliabadi-Wahle
, James Imatani
, Alison Katherine Conlin
, Brady Bernard
, Monil Shah
, Dottie Wadell
, Deborah R. Laxague
, Lu Wen
, Qiao Li
, Gregory T. Wolf
, Walter John Urba
, David B. Page

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Journal of Clinical Oncology
Volume	37
DOIs	https://doi.org/10.1200/jco.2019.37.15_suppl.e12070
State	Published - May 20 2019

Disciplines

Oncology
Pathology
Internal Medicine
Medicine and Health Sciences

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Sanchez, K., Martel, M., Chang, S.-C., Wu, Y., Sun, Z., Nyberg, R., Redmond, W. L., Pucilowska, J., Aliabadi-Wahle, S., Imatani, J., Conlin, A. K., Bernard, B., Shah, M., Wadell, D., Laxague, D. R., Wen, L., Li, Q., Wolf, G. T., Urba, W. J., & Page, D. B. (2019). Evaluation of immunotherapy (I-O)-associated immune cell (IC) dynamics and PD-L1 expression using multispectral immunohistochemistry (mIHC) and single-cell hierarchical regression modeling in early-stage breast cancer (ESBC). Journal of Clinical Oncology, 37. https://doi.org/10.1200/jco.2019.37.15_suppl.e12070

@article{af9d4f6e17014890a6b7d79c11c211a2,

title = "Evaluation of immunotherapy (I-O)-associated immune cell (IC) dynamics and PD-L1 expression using multispectral immunohistochemistry (mIHC) and single-cell hierarchical regression modeling in early-stage breast cancer (ESBC).",

author = "Katherine Sanchez and Maritza Martel and Shu-Ching Chang and Yaping Wu and Zhaoyu Sun and Richard Nyberg and Redmond, \{William L\} and Joanna Pucilowska and Shaghayegh Aliabadi-Wahle and James Imatani and Conlin, \{Alison Katherine\} and Brady Bernard and Monil Shah and Dottie Wadell and Laxague, \{Deborah R.\} and Lu Wen and Qiao Li and Wolf, \{Gregory T.\} and Urba, \{Walter John\} and Page, \{David B.\}",

note = "e12070 Background: In triple negative breast cancer (TNBC), anti-PD-L1 is associated with gains in overall survival, however only in tumors with 1\% PD-L1+ ICs. Locoregional cytokine therapy is being evaluated as a method of priming and redirecting ICs to tumors, which may increase I-O benefit particularly in PD-L1 negative tumors.",

year = "2019",

month = may,

day = "20",

doi = "10.1200/jco.2019.37.15\_suppl.e12070",

language = "American English",

volume = "37",

journal = "Journal of Clinical Oncology",

}

Sanchez, K, Martel, M, Chang, S-C, Wu, Y, Sun, Z, Nyberg, R, Redmond, WL, Pucilowska, J, Aliabadi-Wahle, S, Imatani, J, Conlin, AK, Bernard, B, Shah, M, Wadell, D, Laxague, DR, Wen, L, Li, Q, Wolf, GT, Urba, WJ & Page, DB 2019, 'Evaluation of immunotherapy (I-O)-associated immune cell (IC) dynamics and PD-L1 expression using multispectral immunohistochemistry (mIHC) and single-cell hierarchical regression modeling in early-stage breast cancer (ESBC).', Journal of Clinical Oncology, vol. 37. https://doi.org/10.1200/jco.2019.37.15_suppl.e12070

Evaluation of immunotherapy (I-O)-associated immune cell (IC) dynamics and PD-L1 expression using multispectral immunohistochemistry (mIHC) and single-cell hierarchical regression modeling in early-stage breast cancer (ESBC). / Sanchez, Katherine; Martel, Maritza; Chang, Shu-Ching et al.
In: Journal of Clinical Oncology, Vol. 37, 20.05.2019.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Evaluation of immunotherapy (I-O)-associated immune cell (IC) dynamics and PD-L1 expression using multispectral immunohistochemistry (mIHC) and single-cell hierarchical regression modeling in early-stage breast cancer (ESBC).

AU - Sanchez, Katherine

AU - Martel, Maritza

AU - Chang, Shu-Ching

AU - Wu, Yaping

AU - Sun, Zhaoyu

AU - Nyberg, Richard

AU - Redmond, William L

AU - Pucilowska, Joanna

AU - Aliabadi-Wahle, Shaghayegh

AU - Imatani, James

AU - Conlin, Alison Katherine

AU - Bernard, Brady

AU - Shah, Monil

AU - Wadell, Dottie

AU - Laxague, Deborah R.

AU - Wen, Lu

AU - Li, Qiao

AU - Wolf, Gregory T.

AU - Urba, Walter John

AU - Page, David B.

N1 - e12070 Background: In triple negative breast cancer (TNBC), anti-PD-L1 is associated with gains in overall survival, however only in tumors with 1% PD-L1+ ICs. Locoregional cytokine therapy is being evaluated as a method of priming and redirecting ICs to tumors, which may increase I-O benefit particularly in PD-L1 negative tumors.

PY - 2019/5/20

Y1 - 2019/5/20

UR - https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.e12070

U2 - 10.1200/jco.2019.37.15_suppl.e12070

DO - 10.1200/jco.2019.37.15_suppl.e12070

M3 - Article

VL - 37

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

ER -

Sanchez K, Martel M, Chang SC, Wu Y, Sun Z, Nyberg R et al. Evaluation of immunotherapy (I-O)-associated immune cell (IC) dynamics and PD-L1 expression using multispectral immunohistochemistry (mIHC) and single-cell hierarchical regression modeling in early-stage breast cancer (ESBC). Journal of Clinical Oncology. 2019 May 20;37. doi: 10.1200/jco.2019.37.15_suppl.e12070

Evaluation of immunotherapy (I-O)-associated immune cell (IC) dynamics and PD-L1 expression using multispectral immunohistochemistry (mIHC) and single-cell hierarchical regression modeling in early-stage breast cancer (ESBC).

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