Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat

Charles S. Cobbs; Albert Fenoy; David S. Bredt; L. J. Noble

doi:10.1016/S0006-8993(96)01429-1

Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat

Charles S. Cobbs
, Albert Fenoy
, David S. Bredt
, L. J. Noble

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPHd) histochemistry and nitric oxide synthase (NOS) immunocytochemistry were performed on sections of brain after moderate traumatic brain injury. There was a pronounced increase in NADPHd reactivity and an induction of the endothelial NOS (eNOS) isoform in microvessels surrounding the cortical contusion by 24 h post-injury. This altered microvascular state may contribute to barrier breakdown and hyperemia which characterize traumatic brain injury.

Original language	English
Pages (from-to)	336-338
Number of pages	3
Journal	Brain Research
Volume	751
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(96)01429-1
State	Published - Mar 21 1997

Keywords

NADPHd
endothelial nitric oxide synthase
traumatic brain injury

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10.1016/S0006-8993(96)01429-1

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title = "Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat",

abstract = "Reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPHd) histochemistry and nitric oxide synthase (NOS) immunocytochemistry were performed on sections of brain after moderate traumatic brain injury. There was a pronounced increase in NADPHd reactivity and an induction of the endothelial NOS (eNOS) isoform in microvessels surrounding the cortical contusion by 24 h post-injury. This altered microvascular state may contribute to barrier breakdown and hyperemia which characterize traumatic brain injury.",

keywords = "NADPHd, endothelial nitric oxide synthase, traumatic brain injury",

author = "Cobbs, \{Charles S.\} and Albert Fenoy and Bredt, \{David S.\} and Noble, \{L. J.\}",

note = "Funding Information: This research was supported by NS14543 to L.J.N.",

year = "1997",

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doi = "10.1016/S0006-8993(96)01429-1",

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T1 - Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat

AU - Cobbs, Charles S.

AU - Fenoy, Albert

AU - Bredt, David S.

AU - Noble, L. J.

N1 - Funding Information: This research was supported by NS14543 to L.J.N.

PY - 1997/3/21

Y1 - 1997/3/21

N2 - Reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPHd) histochemistry and nitric oxide synthase (NOS) immunocytochemistry were performed on sections of brain after moderate traumatic brain injury. There was a pronounced increase in NADPHd reactivity and an induction of the endothelial NOS (eNOS) isoform in microvessels surrounding the cortical contusion by 24 h post-injury. This altered microvascular state may contribute to barrier breakdown and hyperemia which characterize traumatic brain injury.

AB - Reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPHd) histochemistry and nitric oxide synthase (NOS) immunocytochemistry were performed on sections of brain after moderate traumatic brain injury. There was a pronounced increase in NADPHd reactivity and an induction of the endothelial NOS (eNOS) isoform in microvessels surrounding the cortical contusion by 24 h post-injury. This altered microvascular state may contribute to barrier breakdown and hyperemia which characterize traumatic brain injury.

KW - NADPHd

KW - endothelial nitric oxide synthase

KW - traumatic brain injury

UR - https://www.scopus.com/pages/publications/0030898997

U2 - 10.1016/S0006-8993(96)01429-1

DO - 10.1016/S0006-8993(96)01429-1

M3 - Article

C2 - 9099824

AN - SCOPUS:0030898997

SN - 0006-8993

VL - 751

SP - 336

EP - 338

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat

Abstract

Keywords

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