FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy

Stephen T. Chen; Prabha Siddarth; David A. Merrill; Jacqueline Martinez; Natacha D. Emerson; Jie Liu; Koon Pong Wong; Nagichettiar Satyamurthy; Christopher C. Giza; Sung Cheng Huang; Robert P. Fitzsimmons; Julian Bailes; Bennet Omalu; Jorge R. Barrio; Gary W. Small

doi:10.3233/AIAD200032

FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy

Stephen T. Chen, Prabha Siddarth, David A. Merrill, Jacqueline Martinez, Natacha D. Emerson, Jie Liu, Koon Pong Wong, Nagichettiar Satyamurthy, Christopher C. Giza, Sung Cheng Huang, Robert P. Fitzsimmons, Julian Bailes, Bennet Omalu, Jorge R. Barrio, Gary W. Small

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Background: Our group has shown that in vivo tau brain binding patterns from FDDNP-PET scans in retired professional football players with suspected chronic traumatic encephalopathy differ from those of tau and amyloid aggregate binding observed in Alzheimer's disease (AD) patients and cognitively-intact controls. Objective: To compare these findings with those from military personnel with histories of mild traumatic brain injury (mTBI). Methods: FDDNP-PET brain scans were compared among 7 military personnel and 15 retired players with mTBI histories and cognitive and/or mood symptoms, 24 AD patients, and 28 cognitively-intact controls. Nonparametric ANCOVAs with Tukey-Kramer adjusted post-hoc comparisons were used to test for significant differences in regional FDDNP binding among subject groups. Results: FDDNP brain binding was higher in military personnel compared to controls in the amygdala, midbrain, thalamus, pons, frontal and anterior and posterior cingulate regions (p<0.01-0.0001). Binding patterns in the military personnel were similar to those of the players except for the amygdala and striatum (binding higher in players; p=0.02-0.003). Compared with the AD group, the military personnel showed higher binding in the midbrain (p=0.0008) and pons (p=0.002) and lower binding in the medial temporal, lateral temporal, and parietal regions (all p=0.02). Conclusion: This first study of in vivo tau and amyloid brain signals in military personnel with histories of mTBI shows binding patterns similar to those of retired football players and distinct from the binding patterns in AD and normal aging, suggesting the potential value of FDDNP-PET for early detection and treatment monitoring in varied at-risk populations.

Original language	English
Title of host publication	Handbook of Traumatic Brain Injury and Neurodegeneration
Editors	Rudy J. Castellani
Publisher	IOS Press
Pages	449-458
Number of pages	10
ISBN (Electronic)	9781643680644
DOIs	https://doi.org/10.3233/AIAD200032
State	Published - 2020

Publication series

Name	Advances in Alzheimer's Disease
Volume	7
ISSN (Print)	2210-5727
ISSN (Electronic)	2210-5735

Keywords

Alzheimer's disease
FDDNP-PET
brain tau and amyloid
chronic traumatic encephalopathy
mild traumatic brain injury
military personnel
retired professional football players

Access to Document

10.3233/AIAD200032

Cite this

Chen, S. T., Siddarth, P., Merrill, D. A., Martinez, J., Emerson, N. D., Liu, J., Wong, K. P., Satyamurthy, N., Giza, C. C., Huang, S. C., Fitzsimmons, R. P., Bailes, J., Omalu, B., Barrio, J. R., & Small, G. W. (2020). FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy. In R. J. Castellani (Ed.), Handbook of Traumatic Brain Injury and Neurodegeneration (pp. 449-458). (Advances in Alzheimer's Disease; Vol. 7). IOS Press. https://doi.org/10.3233/AIAD200032

@inbook{d8faecac5bfd4e1195a7d30a7d9f316f,

title = "FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy",

abstract = "Background: Our group has shown that in vivo tau brain binding patterns from FDDNP-PET scans in retired professional football players with suspected chronic traumatic encephalopathy differ from those of tau and amyloid aggregate binding observed in Alzheimer's disease (AD) patients and cognitively-intact controls. Objective: To compare these findings with those from military personnel with histories of mild traumatic brain injury (mTBI). Methods: FDDNP-PET brain scans were compared among 7 military personnel and 15 retired players with mTBI histories and cognitive and/or mood symptoms, 24 AD patients, and 28 cognitively-intact controls. Nonparametric ANCOVAs with Tukey-Kramer adjusted post-hoc comparisons were used to test for significant differences in regional FDDNP binding among subject groups. Results: FDDNP brain binding was higher in military personnel compared to controls in the amygdala, midbrain, thalamus, pons, frontal and anterior and posterior cingulate regions (p<0.01-0.0001). Binding patterns in the military personnel were similar to those of the players except for the amygdala and striatum (binding higher in players; p=0.02-0.003). Compared with the AD group, the military personnel showed higher binding in the midbrain (p=0.0008) and pons (p=0.002) and lower binding in the medial temporal, lateral temporal, and parietal regions (all p=0.02). Conclusion: This first study of in vivo tau and amyloid brain signals in military personnel with histories of mTBI shows binding patterns similar to those of retired football players and distinct from the binding patterns in AD and normal aging, suggesting the potential value of FDDNP-PET for early detection and treatment monitoring in varied at-risk populations.",

keywords = "Alzheimer's disease, FDDNP-PET, brain tau and amyloid, chronic traumatic encephalopathy, mild traumatic brain injury, military personnel, retired professional football players",

author = "Chen, {Stephen T.} and Prabha Siddarth and Merrill, {David A.} and Jacqueline Martinez and Emerson, {Natacha D.} and Jie Liu and Wong, {Koon Pong} and Nagichettiar Satyamurthy and Giza, {Christopher C.} and Huang, {Sung Cheng} and Fitzsimmons, {Robert P.} and Julian Bailes and Bennet Omalu and Barrio, {Jorge R.} and Small, {Gary W.}",

year = "2020",

doi = "10.3233/AIAD200032",

language = "English",

series = "Advances in Alzheimer's Disease",

publisher = "IOS Press",

pages = "449--458",

editor = "Castellani, {Rudy J.}",

booktitle = "Handbook of Traumatic Brain Injury and Neurodegeneration",

}

Chen, ST, Siddarth, P, Merrill, DA, Martinez, J, Emerson, ND, Liu, J, Wong, KP, Satyamurthy, N, Giza, CC, Huang, SC, Fitzsimmons, RP, Bailes, J, Omalu, B, Barrio, JR & Small, GW 2020, FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy. in RJ Castellani (ed.), Handbook of Traumatic Brain Injury and Neurodegeneration. Advances in Alzheimer's Disease, vol. 7, IOS Press, pp. 449-458. https://doi.org/10.3233/AIAD200032

FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy. / Chen, Stephen T.; Siddarth, Prabha; Merrill, David A. et al.
Handbook of Traumatic Brain Injury and Neurodegeneration. ed. / Rudy J. Castellani. IOS Press, 2020. p. 449-458 (Advances in Alzheimer's Disease; Vol. 7).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy

AU - Chen, Stephen T.

AU - Siddarth, Prabha

AU - Merrill, David A.

AU - Martinez, Jacqueline

AU - Emerson, Natacha D.

AU - Liu, Jie

AU - Wong, Koon Pong

AU - Satyamurthy, Nagichettiar

AU - Giza, Christopher C.

AU - Huang, Sung Cheng

AU - Fitzsimmons, Robert P.

AU - Bailes, Julian

AU - Omalu, Bennet

AU - Barrio, Jorge R.

AU - Small, Gary W.

PY - 2020

Y1 - 2020

N2 - Background: Our group has shown that in vivo tau brain binding patterns from FDDNP-PET scans in retired professional football players with suspected chronic traumatic encephalopathy differ from those of tau and amyloid aggregate binding observed in Alzheimer's disease (AD) patients and cognitively-intact controls. Objective: To compare these findings with those from military personnel with histories of mild traumatic brain injury (mTBI). Methods: FDDNP-PET brain scans were compared among 7 military personnel and 15 retired players with mTBI histories and cognitive and/or mood symptoms, 24 AD patients, and 28 cognitively-intact controls. Nonparametric ANCOVAs with Tukey-Kramer adjusted post-hoc comparisons were used to test for significant differences in regional FDDNP binding among subject groups. Results: FDDNP brain binding was higher in military personnel compared to controls in the amygdala, midbrain, thalamus, pons, frontal and anterior and posterior cingulate regions (p<0.01-0.0001). Binding patterns in the military personnel were similar to those of the players except for the amygdala and striatum (binding higher in players; p=0.02-0.003). Compared with the AD group, the military personnel showed higher binding in the midbrain (p=0.0008) and pons (p=0.002) and lower binding in the medial temporal, lateral temporal, and parietal regions (all p=0.02). Conclusion: This first study of in vivo tau and amyloid brain signals in military personnel with histories of mTBI shows binding patterns similar to those of retired football players and distinct from the binding patterns in AD and normal aging, suggesting the potential value of FDDNP-PET for early detection and treatment monitoring in varied at-risk populations.

AB - Background: Our group has shown that in vivo tau brain binding patterns from FDDNP-PET scans in retired professional football players with suspected chronic traumatic encephalopathy differ from those of tau and amyloid aggregate binding observed in Alzheimer's disease (AD) patients and cognitively-intact controls. Objective: To compare these findings with those from military personnel with histories of mild traumatic brain injury (mTBI). Methods: FDDNP-PET brain scans were compared among 7 military personnel and 15 retired players with mTBI histories and cognitive and/or mood symptoms, 24 AD patients, and 28 cognitively-intact controls. Nonparametric ANCOVAs with Tukey-Kramer adjusted post-hoc comparisons were used to test for significant differences in regional FDDNP binding among subject groups. Results: FDDNP brain binding was higher in military personnel compared to controls in the amygdala, midbrain, thalamus, pons, frontal and anterior and posterior cingulate regions (p<0.01-0.0001). Binding patterns in the military personnel were similar to those of the players except for the amygdala and striatum (binding higher in players; p=0.02-0.003). Compared with the AD group, the military personnel showed higher binding in the midbrain (p=0.0008) and pons (p=0.002) and lower binding in the medial temporal, lateral temporal, and parietal regions (all p=0.02). Conclusion: This first study of in vivo tau and amyloid brain signals in military personnel with histories of mTBI shows binding patterns similar to those of retired football players and distinct from the binding patterns in AD and normal aging, suggesting the potential value of FDDNP-PET for early detection and treatment monitoring in varied at-risk populations.

KW - Alzheimer's disease

KW - FDDNP-PET

KW - brain tau and amyloid

KW - chronic traumatic encephalopathy

KW - mild traumatic brain injury

KW - military personnel

KW - retired professional football players

UR - http://www.scopus.com/inward/record.url?scp=85083719032&partnerID=8YFLogxK

U2 - 10.3233/AIAD200032

DO - 10.3233/AIAD200032

M3 - Chapter

AN - SCOPUS:85083719032

T3 - Advances in Alzheimer's Disease

SP - 449

EP - 458

BT - Handbook of Traumatic Brain Injury and Neurodegeneration

A2 - Castellani, Rudy J.

PB - IOS Press

ER -

FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy

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