Glioblastoma: Biology, Diagnosis, and Treatment

Akanksha Sharma; Maciej M. Mrugala; Jan Buckner

doi:10.1016/B978-0-12-801238-3.65616-7

Glioblastoma: Biology, Diagnosis, and Treatment

Akanksha Sharma
, Maciej M. Mrugala
, Jan Buckner

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Glioblastoma accounts for the majority of malignant primary brain tumors and is an aggressive cancer with high morbidity and mortality. Despite surgical resection, radiation and chemotherapy, survival can still be as little as 15 months. This article aims to provide a concise summary of this cancer, discussing its history, epidemiology, etiology and classification, its clinical presentation and diagnosis, and current treatment modalities as well as their rationale. There continue to be significant advances that hold great promise for treatments for this tumor, and we discuss several key developments that are on the horizon.

Original language	English
Title of host publication	Encyclopedia of Cancer, Third Edition
Subtitle of host publication	Volumes 1-3
Publisher	Elsevier
Pages	V2:154-V2:164
Volume	2
ISBN (Electronic)	9780128124840
ISBN (Print)	9780128124857
DOIs	https://doi.org/10.1016/B978-0-12-801238-3.65616-7
State	Published - Jan 1 2018
Externally published	Yes

Keywords

Brain cancer
Brain tumor
Chemotherapy
Glial neoplasm
Glioblastoma
Glioma
Radiotherapy

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10.1016/B978-0-12-801238-3.65616-7

Cite this

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title = "Glioblastoma: Biology, Diagnosis, and Treatment",

abstract = "Glioblastoma accounts for the majority of malignant primary brain tumors and is an aggressive cancer with high morbidity and mortality. Despite surgical resection, radiation and chemotherapy, survival can still be as little as 15 months. This article aims to provide a concise summary of this cancer, discussing its history, epidemiology, etiology and classification, its clinical presentation and diagnosis, and current treatment modalities as well as their rationale. There continue to be significant advances that hold great promise for treatments for this tumor, and we discuss several key developments that are on the horizon.",

keywords = "Brain cancer, Brain tumor, Chemotherapy, Glial neoplasm, Glioblastoma, Glioma, Radiotherapy",

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T2 - Biology, Diagnosis, and Treatment

AU - Sharma, Akanksha

AU - Mrugala, Maciej M.

AU - Buckner, Jan

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Glioblastoma accounts for the majority of malignant primary brain tumors and is an aggressive cancer with high morbidity and mortality. Despite surgical resection, radiation and chemotherapy, survival can still be as little as 15 months. This article aims to provide a concise summary of this cancer, discussing its history, epidemiology, etiology and classification, its clinical presentation and diagnosis, and current treatment modalities as well as their rationale. There continue to be significant advances that hold great promise for treatments for this tumor, and we discuss several key developments that are on the horizon.

AB - Glioblastoma accounts for the majority of malignant primary brain tumors and is an aggressive cancer with high morbidity and mortality. Despite surgical resection, radiation and chemotherapy, survival can still be as little as 15 months. This article aims to provide a concise summary of this cancer, discussing its history, epidemiology, etiology and classification, its clinical presentation and diagnosis, and current treatment modalities as well as their rationale. There continue to be significant advances that hold great promise for treatments for this tumor, and we discuss several key developments that are on the horizon.

KW - Brain cancer

KW - Brain tumor

KW - Chemotherapy

KW - Glial neoplasm

KW - Glioblastoma

KW - Glioma

KW - Radiotherapy

UR - https://www.scopus.com/pages/publications/105000735396

U2 - 10.1016/B978-0-12-801238-3.65616-7

DO - 10.1016/B978-0-12-801238-3.65616-7

M3 - Chapter

AN - SCOPUS:105000735396

SN - 9780128124857

VL - 2

SP - V2:154-V2:164

BT - Encyclopedia of Cancer, Third Edition

PB - Elsevier

ER -

Glioblastoma: Biology, Diagnosis, and Treatment

Abstract

Keywords

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