Integrative combination of high-plex digital profiling techniques and cluster analysis to reveal complex immune biology in the tumour microenvironment of mesothelioma

C. Ballesteros-Merino; T. Herz; S.E. Church; M. Widmaier; A. Budco; D. Medrikova; I. Kanchev; A. Spitzmueller; A. Shaepe; A. White; J. Reeves; A.H. Sullivan; M. Bailey; S. Jensen; J. Handy; R. Sanborn; C. Bifulco; S. Warren; J.M. Beechem; B. Fox

doi:10.1093/ANNONC/MDZ239.042

Integrative combination of high-plex digital profiling techniques and cluster analysis to reveal complex immune biology in the tumour microenvironment of mesothelioma

C. Ballesteros-Merino
, T. Herz
, S.E. Church
, M. Widmaier
, A. Budco
, D. Medrikova
, I. Kanchev
, A. Spitzmueller
, A. Shaepe
, A. White
, J. Reeves
, A.H. Sullivan
, M. Bailey
, S. Jensen
, J. Handy
, R. Sanborn
, C. Bifulco
, S. Warren
, J.M. Beechem
, B. Fox

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Annals of Oncology
Volume	30
DOIs	https://doi.org/10.1093/ANNONC/MDZ239.042
State	Published - Oct 1 2019

Disciplines

Biology
Business Administration, Management, and Operations
Medicine and Health Sciences

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10.1093/ANNONC/MDZ239.042License: Unspecified

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Ballesteros-Merino, C., Herz, T., Church, S. E., Widmaier, M., Budco, A., Medrikova, D., Kanchev, I., Spitzmueller, A., Shaepe, A., White, A., Reeves, J., Sullivan, A. H., Bailey, M., Jensen, S., Handy, J., Sanborn, R., Bifulco, C., Warren, S., Beechem, J. M., & Fox, B. (2019). Integrative combination of high-plex digital profiling techniques and cluster analysis to reveal complex immune biology in the tumour microenvironment of mesothelioma. Annals of Oncology, 30. https://doi.org/10.1093/ANNONC/MDZ239.042

@article{d9d860b2aa24415bb3fb8b6d71a8b0ff,

title = "Integrative combination of high-plex digital profiling techniques and cluster analysis to reveal complex immune biology in the tumour microenvironment of mesothelioma",

author = "C. Ballesteros-Merino and T. Herz and S.E. Church and M. Widmaier and A. Budco and D. Medrikova and I. Kanchev and A. Spitzmueller and A. Shaepe and A. White and J. Reeves and A.H. Sullivan and M. Bailey and S. Jensen and J. Handy and R. Sanborn and C. Bifulco and S. Warren and J.M. Beechem and B. Fox",

note = "Malignant mesothelioma is an aggressive cancer with poor prognosis and few effective therapies. Due to its derivation from the mesothelium of the lung, immune cells in the tumor microenvironment (TME) may behave differently than in other solid tumors. We describe the combination of two techniques to spatially characterize the tumor-immune profile in mesothelioma.",

year = "2019",

month = oct,

day = "1",

doi = "10.1093/ANNONC/MDZ239.042",

language = "American English",

volume = "30",

journal = "Annals of Oncology",

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Ballesteros-Merino, C, Herz, T, Church, SE, Widmaier, M, Budco, A, Medrikova, D, Kanchev, I, Spitzmueller, A, Shaepe, A, White, A, Reeves, J, Sullivan, AH, Bailey, M, Jensen, S, Handy, J, Sanborn, R, Bifulco, C, Warren, S, Beechem, JM & Fox, B 2019, 'Integrative combination of high-plex digital profiling techniques and cluster analysis to reveal complex immune biology in the tumour microenvironment of mesothelioma', Annals of Oncology, vol. 30. https://doi.org/10.1093/ANNONC/MDZ239.042

TY - JOUR

T1 - Integrative combination of high-plex digital profiling techniques and cluster analysis to reveal complex immune biology in the tumour microenvironment of mesothelioma

AU - Ballesteros-Merino, C.

AU - Herz, T.

AU - Church, S.E.

AU - Widmaier, M.

AU - Budco, A.

AU - Medrikova, D.

AU - Kanchev, I.

AU - Spitzmueller, A.

AU - Shaepe, A.

AU - White, A.

AU - Reeves, J.

AU - Sullivan, A.H.

AU - Bailey, M.

AU - Jensen, S.

AU - Handy, J.

AU - Sanborn, R.

AU - Bifulco, C.

AU - Warren, S.

AU - Beechem, J.M.

AU - Fox, B.

N1 - Malignant mesothelioma is an aggressive cancer with poor prognosis and few effective therapies. Due to its derivation from the mesothelium of the lung, immune cells in the tumor microenvironment (TME) may behave differently than in other solid tumors. We describe the combination of two techniques to spatially characterize the tumor-immune profile in mesothelioma.

PY - 2019/10/1

Y1 - 2019/10/1

UR - https://www.annalsofoncology.org/article/S0923-7534(19)58362-4/fulltext

U2 - 10.1093/ANNONC/MDZ239.042

DO - 10.1093/ANNONC/MDZ239.042

M3 - Article

VL - 30

JO - Annals of Oncology

JF - Annals of Oncology

ER -

Integrative combination of high-plex digital profiling techniques and cluster analysis to reveal complex immune biology in the tumour microenvironment of mesothelioma

Disciplines

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