Intricate Genetic Programs Controlling Dormancy in Mycobacterium tuberculosis

Eliza J.R. Peterson; Abrar A. Abidi; Mario L. Arrieta-Ortiz; Boris Aguilar; James T. Yurkovich; Amardeep Kaur; Min Pan; Vivek Srinivas; Ilya Shmulevich; Nitin S. Baliga

doi:10.1016/j.celrep.2020.107577

Intricate Genetic Programs Controlling Dormancy in Mycobacterium tuberculosis

Eliza J.R. Peterson
, Abrar A. Abidi
, Mario L. Arrieta-Ortiz
, Boris Aguilar
, James T. Yurkovich
, Amardeep Kaur
, Min Pan
, Vivek Srinivas
, Ilya Shmulevich
, Nitin S. Baliga

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Mycobacterium tuberculosis (MTB) persists within the host by counteracting disparate stressors including hypoxia. Peterson et al. report a transcriptional program that coordinates sequential state transitions to drive MTB in and out of hypoxia-induced dormancy. Among varied properties, this program encodes advanced preparedness to infect the host in favorable conditions.

Original language	English
Article number	107577
Journal	Cell Reports
Volume	31
Issue number	4
DOIs	https://doi.org/10.1016/j.celrep.2020.107577
State	Published - Apr 28 2020

Keywords

Mycobacterium tuberculosis
dormancy
gene regulatory network
granuloma
hypoxia
reactor
regulatory motifs
state transition
systems biology
transcriptional state

Access to Document

10.1016/j.celrep.2020.107577

Cite this

@article{de1fce3d148144f9b9e3af12547a5e9b,

title = "Intricate Genetic Programs Controlling Dormancy in Mycobacterium tuberculosis",

abstract = "Mycobacterium tuberculosis (MTB) persists within the host by counteracting disparate stressors including hypoxia. Peterson et al. report a transcriptional program that coordinates sequential state transitions to drive MTB in and out of hypoxia-induced dormancy. Among varied properties, this program encodes advanced preparedness to infect the host in favorable conditions.",

keywords = "Mycobacterium tuberculosis, dormancy, gene regulatory network, granuloma, hypoxia, reactor, regulatory motifs, state transition, systems biology, transcriptional state",

author = "Peterson, \{Eliza J.R.\} and Abidi, \{Abrar A.\} and Arrieta-Ortiz, \{Mario L.\} and Boris Aguilar and Yurkovich, \{James T.\} and Amardeep Kaur and Min Pan and Vivek Srinivas and Ilya Shmulevich and Baliga, \{Nitin S.\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = apr,

day = "28",

doi = "10.1016/j.celrep.2020.107577",

language = "English",

volume = "31",

journal = "Cell Reports",

issn = "2639-1856",

publisher = "Elsevier B.V.",

number = "4",

}

TY - JOUR

T1 - Intricate Genetic Programs Controlling Dormancy in Mycobacterium tuberculosis

AU - Peterson, Eliza J.R.

AU - Abidi, Abrar A.

AU - Arrieta-Ortiz, Mario L.

AU - Aguilar, Boris

AU - Yurkovich, James T.

AU - Kaur, Amardeep

AU - Pan, Min

AU - Srinivas, Vivek

AU - Shmulevich, Ilya

AU - Baliga, Nitin S.

PY - 2020/4/28

Y1 - 2020/4/28

N2 - Mycobacterium tuberculosis (MTB) persists within the host by counteracting disparate stressors including hypoxia. Peterson et al. report a transcriptional program that coordinates sequential state transitions to drive MTB in and out of hypoxia-induced dormancy. Among varied properties, this program encodes advanced preparedness to infect the host in favorable conditions.

AB - Mycobacterium tuberculosis (MTB) persists within the host by counteracting disparate stressors including hypoxia. Peterson et al. report a transcriptional program that coordinates sequential state transitions to drive MTB in and out of hypoxia-induced dormancy. Among varied properties, this program encodes advanced preparedness to infect the host in favorable conditions.

KW - Mycobacterium tuberculosis

KW - dormancy

KW - gene regulatory network

KW - granuloma

KW - hypoxia

KW - reactor

KW - regulatory motifs

KW - state transition

KW - systems biology

KW - transcriptional state

UR - https://www.scopus.com/pages/publications/85083781477

U2 - 10.1016/j.celrep.2020.107577

DO - 10.1016/j.celrep.2020.107577

M3 - Article

C2 - 32348771

AN - SCOPUS:85083781477

SN - 2639-1856

VL - 31

JO - Cell Reports

JF - Cell Reports

IS - 4

M1 - 107577

ER -

Intricate Genetic Programs Controlling Dormancy in Mycobacterium tuberculosis

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this