Margin Analysis: Squamous Cell Carcinoma of the Oropharynx

Felix W. Sim; Hong D. Xiao; R. Bryan Bell

doi:10.1016/j.coms.2017.03.004

Margin Analysis: Squamous Cell Carcinoma of the Oropharynx

Felix W. Sim
, Hong D. Xiao
, R. Bryan Bell

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Because of the common shared risk factors of smoking and heavy alcohol consumption, literature involving oropharyngeal squamous cell carcinoma (OPSCC) is often combined with oral squamous cell carcinoma. Human papilloma virus is now confirmed to be a major risk factor of OPSCC with its distinct epidemiology and favorable treatment outcome. The impact of adjuvant chemoradiation in the setting of positive surgical margins remains unclear but is likely influenced by tumor biology. This article reviews the tumor biology of OPSCC and summarizes recent findings on outcomes following surgical treatment of OPSCC.

Original language	English
Pages (from-to)	269-280
Number of pages	12
Journal	Oral and Maxillofacial Surgery Clinics of North America
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.coms.2017.03.004
State	Published - Aug 2017

Keywords

HPV
Head and neck
Local control
Oropharyngeal cancer
Prognosis
Squamous cell carcinoma
Surgical margins

Access to Document

10.1016/j.coms.2017.03.004

Cite this

@article{cf5e31424b7b4e4fbec4fafe171c7e2e,

title = "Margin Analysis: Squamous Cell Carcinoma of the Oropharynx",

abstract = "Because of the common shared risk factors of smoking and heavy alcohol consumption, literature involving oropharyngeal squamous cell carcinoma (OPSCC) is often combined with oral squamous cell carcinoma. Human papilloma virus is now confirmed to be a major risk factor of OPSCC with its distinct epidemiology and favorable treatment outcome. The impact of adjuvant chemoradiation in the setting of positive surgical margins remains unclear but is likely influenced by tumor biology. This article reviews the tumor biology of OPSCC and summarizes recent findings on outcomes following surgical treatment of OPSCC.",

keywords = "HPV, Head and neck, Local control, Oropharyngeal cancer, Prognosis, Squamous cell carcinoma, Surgical margins",

author = "Sim, \{Felix W.\} and Xiao, \{Hong D.\} and Bell, \{R. Bryan\}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = aug,

doi = "10.1016/j.coms.2017.03.004",

language = "English",

volume = "29",

pages = "269--280",

journal = "Oral and Maxillofacial Surgery Clinics of North America",

issn = "1042-3699",

publisher = "W.B. Saunders",

number = "3",

}

TY - JOUR

T1 - Margin Analysis

T2 - Squamous Cell Carcinoma of the Oropharynx

AU - Sim, Felix W.

AU - Xiao, Hong D.

AU - Bell, R. Bryan

PY - 2017/8

Y1 - 2017/8

N2 - Because of the common shared risk factors of smoking and heavy alcohol consumption, literature involving oropharyngeal squamous cell carcinoma (OPSCC) is often combined with oral squamous cell carcinoma. Human papilloma virus is now confirmed to be a major risk factor of OPSCC with its distinct epidemiology and favorable treatment outcome. The impact of adjuvant chemoradiation in the setting of positive surgical margins remains unclear but is likely influenced by tumor biology. This article reviews the tumor biology of OPSCC and summarizes recent findings on outcomes following surgical treatment of OPSCC.

AB - Because of the common shared risk factors of smoking and heavy alcohol consumption, literature involving oropharyngeal squamous cell carcinoma (OPSCC) is often combined with oral squamous cell carcinoma. Human papilloma virus is now confirmed to be a major risk factor of OPSCC with its distinct epidemiology and favorable treatment outcome. The impact of adjuvant chemoradiation in the setting of positive surgical margins remains unclear but is likely influenced by tumor biology. This article reviews the tumor biology of OPSCC and summarizes recent findings on outcomes following surgical treatment of OPSCC.

KW - HPV

KW - Head and neck

KW - Local control

KW - Oropharyngeal cancer

KW - Prognosis

KW - Squamous cell carcinoma

KW - Surgical margins

UR - https://www.scopus.com/pages/publications/85023197939

U2 - 10.1016/j.coms.2017.03.004

DO - 10.1016/j.coms.2017.03.004

M3 - Review article

C2 - 28709530

AN - SCOPUS:85023197939

SN - 1042-3699

VL - 29

SP - 269

EP - 280

JO - Oral and Maxillofacial Surgery Clinics of North America

JF - Oral and Maxillofacial Surgery Clinics of North America

IS - 3

ER -

Margin Analysis: Squamous Cell Carcinoma of the Oropharynx

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this