Migraine headache in patients with spontaneous coronary artery dissection: A report of the iSCAD Registry.

Bryan J Wells; Malissa J Wood; Anne E O'Duffy; Jennifer A Sumner; Gerald Chi; Anna Grodzinsky; Heather L Gornik; Daniella Kadian-Dodov; Angela Taylor; Connie N Hess; Monika Sanghavi; Stanislav Henkin; Gretchen Wells; Lori Tam; James Orford; Kathryn Lindley; Dharam J Kumbhani; Clara Vitarello; Fahad Alkhalfan; C Michael Gibson; Katherine K Leon; Sahar Naderi; Esther Sh Kim

Migraine headache in patients with spontaneous coronary artery dissection: A report of the iSCAD Registry.

Bryan J Wells
, Malissa J Wood
, Anne E O'Duffy
, Jennifer A Sumner
, Gerald Chi
, Anna Grodzinsky
, Heather L Gornik
, Daniella Kadian-Dodov
, Angela Taylor
, Connie N Hess
, Monika Sanghavi
, Stanislav Henkin
, Gretchen Wells
, Lori Tam
, James Orford
, Kathryn Lindley
, Dharam J Kumbhani
, Clara Vitarello
, Fahad Alkhalfan
, C Michael Gibson

Katherine K Leon, Sahar Naderi, Esther Sh Kim

Research output: Contribution to journal › Article

Abstract

Introduction: Spontaneous coronary artery dissection (SCAD) is a nonatherosclerotic cause of myocardial infarction. Migraine headache has been reported to be common among patients with SCAD, but the degree of migraine-related disability has not been quantified.

Methods: Clinical data and headache variables were obtained from the baseline assessment of the prospective, multicenter iSCAD Registry. Migraine-related disability was quantified using the self-reported Migraine Disability Assessment (MIDAS). Demographic, clinical, psychosocial, and medical characteristics from data entry forms were compared between patients with and without migraine.

Results: Of the 773 patients with available data, 46% reported previous or current migraines. Those with migraines were more likely to be women (96.9% vs 90.3%, p = 0.0003). The presence of underlying carotid fibromuscular dysplasia was associated with migraine (35% vs 27%, p = 0.0175). There was not a significant association with carotid artery dissection and migraine. Current migraine frequency was less than monthly (58%), monthly (24%), weekly (16%), and daily (3%). Triptan use was reported in 32.5% of patients, and 17.5% used daily migraine prophylactic medications. Using the MIDAS to quantify disability related to migraine, 60.2% reported little or no disability, 14.4% mild, 12.7% moderate, and 12.7% severe. The mean MIDAS score was 9.9 (mild to moderate disability). Patients with SCAD had higher rates of depression and anxiety (28.2% vs 17.7% [p = 0.0004] and 35.3% vs 26.7% [p = 0.0099], respectively).

Conclusions: Migraines are common, frequent, and a source of disability in patients with SCAD. The association between female sex, anxiety, and depression may provide some insight for potential treatment modalities.

Keywords: fibromuscular dysplasia (FMD); migraine headache; myocardial infarction; spontaneous coronary artery dissection (SCAD).

Original language	Undefined/Unknown
Journal	Articles, Abstracts, and Reports
State	Published - Jun 1 2024

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http://digitalcommons.providence.org/publications/8987

Cite this

Wells, B. J., Wood, M. J., O'Duffy, A. E., Sumner, J. A., Chi, G., Grodzinsky, A., Gornik, H. L., Kadian-Dodov, D., Taylor, A., Hess, C. N., Sanghavi, M., Henkin, S., Wells, G., Tam, L., Orford, J., Lindley, K., Kumbhani, D. J., Vitarello, C., Alkhalfan, F., ... Kim, E. S. (2024). Migraine headache in patients with spontaneous coronary artery dissection: A report of the iSCAD Registry. Articles, Abstracts, and Reports. http://digitalcommons.providence.org/publications/8987

@article{d22beff128fb4343918032f54343ba1c,

title = "Migraine headache in patients with spontaneous coronary artery dissection: A report of the iSCAD Registry.",

abstract = "Introduction: Spontaneous coronary artery dissection (SCAD) is a nonatherosclerotic cause of myocardial infarction. Migraine headache has been reported to be common among patients with SCAD, but the degree of migraine-related disability has not been quantified. Methods: Clinical data and headache variables were obtained from the baseline assessment of the prospective, multicenter iSCAD Registry. Migraine-related disability was quantified using the self-reported Migraine Disability Assessment (MIDAS). Demographic, clinical, psychosocial, and medical characteristics from data entry forms were compared between patients with and without migraine. Results: Of the 773 patients with available data, 46\% reported previous or current migraines. Those with migraines were more likely to be women (96.9\% vs 90.3\%, p = 0.0003). The presence of underlying carotid fibromuscular dysplasia was associated with migraine (35\% vs 27\%, p = 0.0175). There was not a significant association with carotid artery dissection and migraine. Current migraine frequency was less than monthly (58\%), monthly (24\%), weekly (16\%), and daily (3\%). Triptan use was reported in 32.5\% of patients, and 17.5\% used daily migraine prophylactic medications. Using the MIDAS to quantify disability related to migraine, 60.2\% reported little or no disability, 14.4\% mild, 12.7\% moderate, and 12.7\% severe. The mean MIDAS score was 9.9 (mild to moderate disability). Patients with SCAD had higher rates of depression and anxiety (28.2\% vs 17.7\% [p = 0.0004] and 35.3\% vs 26.7\% [p = 0.0099], respectively). Conclusions: Migraines are common, frequent, and a source of disability in patients with SCAD. The association between female sex, anxiety, and depression may provide some insight for potential treatment modalities. Keywords: fibromuscular dysplasia (FMD); migraine headache; myocardial infarction; spontaneous coronary artery dissection (SCAD).",

author = "Wells, \{Bryan J\} and Wood, \{Malissa J\} and O'Duffy, \{Anne E\} and Sumner, \{Jennifer A\} and Gerald Chi and Anna Grodzinsky and Gornik, \{Heather L\} and Daniella Kadian-Dodov and Angela Taylor and Hess, \{Connie N\} and Monika Sanghavi and Stanislav Henkin and Gretchen Wells and Lori Tam and James Orford and Kathryn Lindley and Kumbhani, \{Dharam J\} and Clara Vitarello and Fahad Alkhalfan and Gibson, \{C Michael\} and Leon, \{Katherine K\} and Sahar Naderi and Kim, \{Esther Sh\}",

year = "2024",

month = jun,

day = "1",

language = "Undefined/Unknown",

journal = "Articles, Abstracts, and Reports",

}

Wells, BJ, Wood, MJ, O'Duffy, AE, Sumner, JA, Chi, G, Grodzinsky, A, Gornik, HL, Kadian-Dodov, D, Taylor, A, Hess, CN, Sanghavi, M, Henkin, S, Wells, G, Tam, L, Orford, J, Lindley, K, Kumbhani, DJ, Vitarello, C, Alkhalfan, F, Gibson, CM, Leon, KK, Naderi, S & Kim, ES 2024, 'Migraine headache in patients with spontaneous coronary artery dissection: A report of the iSCAD Registry.', Articles, Abstracts, and Reports. <http://digitalcommons.providence.org/publications/8987>

TY - JOUR

T1 - Migraine headache in patients with spontaneous coronary artery dissection: A report of the iSCAD Registry.

AU - Wells, Bryan J

AU - Wood, Malissa J

AU - O'Duffy, Anne E

AU - Sumner, Jennifer A

AU - Chi, Gerald

AU - Grodzinsky, Anna

AU - Gornik, Heather L

AU - Kadian-Dodov, Daniella

AU - Taylor, Angela

AU - Hess, Connie N

AU - Sanghavi, Monika

AU - Henkin, Stanislav

AU - Wells, Gretchen

AU - Tam, Lori

AU - Orford, James

AU - Lindley, Kathryn

AU - Kumbhani, Dharam J

AU - Vitarello, Clara

AU - Alkhalfan, Fahad

AU - Gibson, C Michael

AU - Leon, Katherine K

AU - Naderi, Sahar

AU - Kim, Esther Sh

PY - 2024/6/1

Y1 - 2024/6/1

N2 - Introduction: Spontaneous coronary artery dissection (SCAD) is a nonatherosclerotic cause of myocardial infarction. Migraine headache has been reported to be common among patients with SCAD, but the degree of migraine-related disability has not been quantified. Methods: Clinical data and headache variables were obtained from the baseline assessment of the prospective, multicenter iSCAD Registry. Migraine-related disability was quantified using the self-reported Migraine Disability Assessment (MIDAS). Demographic, clinical, psychosocial, and medical characteristics from data entry forms were compared between patients with and without migraine. Results: Of the 773 patients with available data, 46% reported previous or current migraines. Those with migraines were more likely to be women (96.9% vs 90.3%, p = 0.0003). The presence of underlying carotid fibromuscular dysplasia was associated with migraine (35% vs 27%, p = 0.0175). There was not a significant association with carotid artery dissection and migraine. Current migraine frequency was less than monthly (58%), monthly (24%), weekly (16%), and daily (3%). Triptan use was reported in 32.5% of patients, and 17.5% used daily migraine prophylactic medications. Using the MIDAS to quantify disability related to migraine, 60.2% reported little or no disability, 14.4% mild, 12.7% moderate, and 12.7% severe. The mean MIDAS score was 9.9 (mild to moderate disability). Patients with SCAD had higher rates of depression and anxiety (28.2% vs 17.7% [p = 0.0004] and 35.3% vs 26.7% [p = 0.0099], respectively). Conclusions: Migraines are common, frequent, and a source of disability in patients with SCAD. The association between female sex, anxiety, and depression may provide some insight for potential treatment modalities. Keywords: fibromuscular dysplasia (FMD); migraine headache; myocardial infarction; spontaneous coronary artery dissection (SCAD).

AB - Introduction: Spontaneous coronary artery dissection (SCAD) is a nonatherosclerotic cause of myocardial infarction. Migraine headache has been reported to be common among patients with SCAD, but the degree of migraine-related disability has not been quantified. Methods: Clinical data and headache variables were obtained from the baseline assessment of the prospective, multicenter iSCAD Registry. Migraine-related disability was quantified using the self-reported Migraine Disability Assessment (MIDAS). Demographic, clinical, psychosocial, and medical characteristics from data entry forms were compared between patients with and without migraine. Results: Of the 773 patients with available data, 46% reported previous or current migraines. Those with migraines were more likely to be women (96.9% vs 90.3%, p = 0.0003). The presence of underlying carotid fibromuscular dysplasia was associated with migraine (35% vs 27%, p = 0.0175). There was not a significant association with carotid artery dissection and migraine. Current migraine frequency was less than monthly (58%), monthly (24%), weekly (16%), and daily (3%). Triptan use was reported in 32.5% of patients, and 17.5% used daily migraine prophylactic medications. Using the MIDAS to quantify disability related to migraine, 60.2% reported little or no disability, 14.4% mild, 12.7% moderate, and 12.7% severe. The mean MIDAS score was 9.9 (mild to moderate disability). Patients with SCAD had higher rates of depression and anxiety (28.2% vs 17.7% [p = 0.0004] and 35.3% vs 26.7% [p = 0.0099], respectively). Conclusions: Migraines are common, frequent, and a source of disability in patients with SCAD. The association between female sex, anxiety, and depression may provide some insight for potential treatment modalities. Keywords: fibromuscular dysplasia (FMD); migraine headache; myocardial infarction; spontaneous coronary artery dissection (SCAD).

M3 - Article

JO - Articles, Abstracts, and Reports

JF - Articles, Abstracts, and Reports

ER -