Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells.

Philippe Diaz; Eric Horne; Cong Xu; Ernest Hamel; Michael Wagenbach; Petrov Ravil R; Benjamin Uhlenbruck; Brian Haas; Parvinder Hothi; Linda Wordeman; Rick Gussio; Nephi Stella

Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells.

Philippe Diaz
, Eric Horne
, Cong Xu
, Ernest Hamel
, Michael Wagenbach
, Petrov Ravil R
, Benjamin Uhlenbruck
, Brian Haas
, Parvinder Hothi
, Linda Wordeman
, Rick Gussio
, Nephi Stella

Research output: Contribution to journal › Article

Abstract

Small molecules that target microtubules (MTs) represent promising therapeutics to treat certain types of cancer, including glioblastoma multiform (GBM). We synthesized modified carbazoles and evaluated their antitumor activity in GBM cells in culture. Modified carbazoles with an ethyl moiety linked to the nitrogen of the carbazole and a carbonyl moiety linked to distinct biaromatic rings exhibited remarkably different killing activities in human GBM cell lines and patient-derived GBM cells, with IC

Original language	Undefined/Unknown
Journal	Articles, Abstracts, and Reports
State	Published - Nov 5 2018

Access to Document

http://digitalcommons.psjhealth.org/publications/809

Cite this

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title = "Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells.",

abstract = "Small molecules that target microtubules (MTs) represent promising therapeutics to treat certain types of cancer, including glioblastoma multiform (GBM). We synthesized modified carbazoles and evaluated their antitumor activity in GBM cells in culture. Modified carbazoles with an ethyl moiety linked to the nitrogen of the carbazole and a carbonyl moiety linked to distinct biaromatic rings exhibited remarkably different killing activities in human GBM cell lines and patient-derived GBM cells, with IC",

author = "Philippe Diaz and Eric Horne and Cong Xu and Ernest Hamel and Michael Wagenbach and \{Ravil R\}, Petrov and Benjamin Uhlenbruck and Brian Haas and Parvinder Hothi and Linda Wordeman and Rick Gussio and Nephi Stella",

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day = "5",

language = "Undefined/Unknown",

journal = "Articles, Abstracts, and Reports",

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TY - JOUR

T1 - Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells.

AU - Diaz, Philippe

AU - Horne, Eric

AU - Xu, Cong

AU - Hamel, Ernest

AU - Wagenbach, Michael

AU - Ravil R, Petrov

AU - Uhlenbruck, Benjamin

AU - Haas, Brian

AU - Hothi, Parvinder

AU - Wordeman, Linda

AU - Gussio, Rick

AU - Stella, Nephi

PY - 2018/11/5

Y1 - 2018/11/5

N2 - Small molecules that target microtubules (MTs) represent promising therapeutics to treat certain types of cancer, including glioblastoma multiform (GBM). We synthesized modified carbazoles and evaluated their antitumor activity in GBM cells in culture. Modified carbazoles with an ethyl moiety linked to the nitrogen of the carbazole and a carbonyl moiety linked to distinct biaromatic rings exhibited remarkably different killing activities in human GBM cell lines and patient-derived GBM cells, with IC

AB - Small molecules that target microtubules (MTs) represent promising therapeutics to treat certain types of cancer, including glioblastoma multiform (GBM). We synthesized modified carbazoles and evaluated their antitumor activity in GBM cells in culture. Modified carbazoles with an ethyl moiety linked to the nitrogen of the carbazole and a carbonyl moiety linked to distinct biaromatic rings exhibited remarkably different killing activities in human GBM cell lines and patient-derived GBM cells, with IC

M3 - Article

JO - Articles, Abstracts, and Reports

JF - Articles, Abstracts, and Reports

ER -