Molecular mechanisms of metastasis

Dave S.B. Hoon; Robert Ferris; Ryo Tanaka; Kelly K. Chong; Catherine Alix‐Panabières; Klaus Pantel

doi:10.1002/jso.21690

Molecular mechanisms of metastasis

Dave S.B. Hoon
, Robert Ferris
, Ryo Tanaka
, Kelly K. Chong
, Catherine Alix‐Panabières
, Klaus Pantel

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The mechanism of metastasis is a complex set of events that build upon each other to achieve successful growth in organ sites beyond the primary tumor. The cumulative events for metastasis of different cancers have both common and specific cancer specific events. This review discusses several key factors in different cancers that are responsible in metastasis, which includes epigenetic regulation of tumor suppressor genes, functional activity of tumor-related chemokine receptors, and circulating tumor cells.

Original language	English
Pages (from-to)	508-517
Number of pages	10
Journal	Journal of Surgical Oncology
Volume	103
Issue number	6
DOIs	https://doi.org/10.1002/jso.21690
State	Published - May 1 2011

Keywords

CTC
chemokine receptor
methylation
microRNA

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title = "Molecular mechanisms of metastasis",

abstract = "The mechanism of metastasis is a complex set of events that build upon each other to achieve successful growth in organ sites beyond the primary tumor. The cumulative events for metastasis of different cancers have both common and specific cancer specific events. This review discusses several key factors in different cancers that are responsible in metastasis, which includes epigenetic regulation of tumor suppressor genes, functional activity of tumor-related chemokine receptors, and circulating tumor cells.",

keywords = "CTC, chemokine receptor, methylation, microRNA",

author = "Hoon, \{Dave S.B.\} and Robert Ferris and Ryo Tanaka and Chong, \{Kelly K.\} and Catherine Alix‐Panabi{\`e}res and Klaus Pantel",

note = "A major topic covered at the First International Symposium on Cancer Metastasis and the Lymphovascular System was the molecular mechanisms of metastasis. This has become of major interest in recent...",

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AU - Hoon, Dave S.B.

AU - Ferris, Robert

AU - Tanaka, Ryo

AU - Chong, Kelly K.

AU - Alix‐Panabières, Catherine

AU - Pantel, Klaus

N1 - A major topic covered at the First International Symposium on Cancer Metastasis and the Lymphovascular System was the molecular mechanisms of metastasis. This has become of major interest in recent...

PY - 2011/5/1

Y1 - 2011/5/1

N2 - The mechanism of metastasis is a complex set of events that build upon each other to achieve successful growth in organ sites beyond the primary tumor. The cumulative events for metastasis of different cancers have both common and specific cancer specific events. This review discusses several key factors in different cancers that are responsible in metastasis, which includes epigenetic regulation of tumor suppressor genes, functional activity of tumor-related chemokine receptors, and circulating tumor cells.

AB - The mechanism of metastasis is a complex set of events that build upon each other to achieve successful growth in organ sites beyond the primary tumor. The cumulative events for metastasis of different cancers have both common and specific cancer specific events. This review discusses several key factors in different cancers that are responsible in metastasis, which includes epigenetic regulation of tumor suppressor genes, functional activity of tumor-related chemokine receptors, and circulating tumor cells.

KW - CTC

KW - chemokine receptor

KW - methylation

KW - microRNA

UR - https://www.scopus.com/pages/publications/79953901990

U2 - 10.1002/jso.21690

DO - 10.1002/jso.21690

M3 - Article

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SN - 0022-4790

VL - 103

SP - 508

EP - 517

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

IS - 6

ER -

Molecular mechanisms of metastasis

Abstract

Keywords

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