New insight into coronary endothelial dysfunction: Role of endothelin

Charles R. Cannan; Verghese Mathew; Amir Lerman

doi:10.1016/S0022-2143(98)90179-2

New insight into coronary endothelial dysfunction: Role of endothelin

Charles R. Cannan
, Verghese Mathew
, Amir Lerman

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

The coronary endothelium plays a central role in the modulation of coronary vascular tone via the production and release of vasoactive mediators. A number of cardiovascular disease states are associated with coronary endothelial dysfunction, which results in an imbalance between vasoactive substances, Endothelial is a potent vasoconstrictor produced by the coronary endothelium and has been implicated In the pathogenesis of coronary endothelial dysfunction. This review examines the relationship between endothelin and coronary endothelial dysfunction as it occurs in a number of cardiovascular disease states and explores potential therapeutic options.

Original language	English
Pages (from-to)	300-305
Number of pages	6
Journal	The Journal of Laboratory and Clinical Medicine
Volume	131
Issue number	4
DOIs	https://doi.org/10.1016/S0022-2143(98)90179-2
State	Published - Apr 1998

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10.1016/S0022-2143(98)90179-2

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@article{957ae6d3e8c945c8b25ce708ff9e7167,

title = "New insight into coronary endothelial dysfunction: Role of endothelin",

abstract = "The coronary endothelium plays a central role in the modulation of coronary vascular tone via the production and release of vasoactive mediators. A number of cardiovascular disease states are associated with coronary endothelial dysfunction, which results in an imbalance between vasoactive substances, Endothelial is a potent vasoconstrictor produced by the coronary endothelium and has been implicated In the pathogenesis of coronary endothelial dysfunction. This review examines the relationship between endothelin and coronary endothelial dysfunction as it occurs in a number of cardiovascular disease states and explores potential therapeutic options.",

author = "Cannan, \{Charles R.\} and Verghese Mathew and Amir Lerman",

note = "Funding Information: Endothelin is an endothelium-derived peptide that exerts profound vasoconstrictive activity in vitro and in vivo. The role of endothelin as a potent systemic and coronary vasoconstrictor has been well established and extensively reviewed. Although numerous vasoactive substances have an influence on coronary vascular tone, our current understanding of the endothelium suggests From the Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Foundation. Supported in part by the Miami Heart Research Institute, the Bruce and Ruth Rappaport Program in Vascular Biology, and the Mayo Foundation. Submitted for publication Jan. 31, 1997; revision submitted June 18, 1997; accepted June 27, 1997. Reprint requests: Amir Lerman, MD, Division of CardiovascularD is-eases and Internal Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN 55905. Copyright {\textcopyright} 1998 by Mosby, Inc. 0022-2143/98 \$5.00 + 0 5/1/87992",

year = "1998",

month = apr,

doi = "10.1016/S0022-2143(98)90179-2",

language = "English",

volume = "131",

pages = "300--305",

journal = "The Journal of Laboratory and Clinical Medicine",

issn = "0022-2143",

publisher = "Mosby Inc.",

number = "4",

}

TY - JOUR

T1 - New insight into coronary endothelial dysfunction

T2 - Role of endothelin

AU - Cannan, Charles R.

AU - Mathew, Verghese

AU - Lerman, Amir

N1 - Funding Information: Endothelin is an endothelium-derived peptide that exerts profound vasoconstrictive activity in vitro and in vivo. The role of endothelin as a potent systemic and coronary vasoconstrictor has been well established and extensively reviewed. Although numerous vasoactive substances have an influence on coronary vascular tone, our current understanding of the endothelium suggests From the Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Foundation. Supported in part by the Miami Heart Research Institute, the Bruce and Ruth Rappaport Program in Vascular Biology, and the Mayo Foundation. Submitted for publication Jan. 31, 1997; revision submitted June 18, 1997; accepted June 27, 1997. Reprint requests: Amir Lerman, MD, Division of CardiovascularD is-eases and Internal Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN 55905. Copyright © 1998 by Mosby, Inc. 0022-2143/98 $5.00 + 0 5/1/87992

PY - 1998/4

Y1 - 1998/4

N2 - The coronary endothelium plays a central role in the modulation of coronary vascular tone via the production and release of vasoactive mediators. A number of cardiovascular disease states are associated with coronary endothelial dysfunction, which results in an imbalance between vasoactive substances, Endothelial is a potent vasoconstrictor produced by the coronary endothelium and has been implicated In the pathogenesis of coronary endothelial dysfunction. This review examines the relationship between endothelin and coronary endothelial dysfunction as it occurs in a number of cardiovascular disease states and explores potential therapeutic options.

AB - The coronary endothelium plays a central role in the modulation of coronary vascular tone via the production and release of vasoactive mediators. A number of cardiovascular disease states are associated with coronary endothelial dysfunction, which results in an imbalance between vasoactive substances, Endothelial is a potent vasoconstrictor produced by the coronary endothelium and has been implicated In the pathogenesis of coronary endothelial dysfunction. This review examines the relationship between endothelin and coronary endothelial dysfunction as it occurs in a number of cardiovascular disease states and explores potential therapeutic options.

UR - https://www.scopus.com/pages/publications/0032055212

U2 - 10.1016/S0022-2143(98)90179-2

DO - 10.1016/S0022-2143(98)90179-2

M3 - Review article

C2 - 9579382

AN - SCOPUS:0032055212

SN - 0022-2143

VL - 131

SP - 300

EP - 305

JO - The Journal of Laboratory and Clinical Medicine

JF - The Journal of Laboratory and Clinical Medicine

IS - 4

ER -

New insight into coronary endothelial dysfunction: Role of endothelin

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