TY - JOUR
T1 - Outcomes of laser thermal therapy for recurrent head and neck cancer
AU - Sercarz, Joel A.
AU - Bublik, Michael
AU - Joo, Jayne
AU - Paiva, Paulo B.
AU - Areco, Kelsy N.
AU - Brandalise, Maria Helena
AU - Loh, Christopher
AU - Masterman-Smith, Michael
AU - Paiva, Marcos B.
N1 - Funding Information:
Sponsorships: This study was supported by the Division of Head and Neck Surgery, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, National Institutes of Health grants K23CA88921 and K22CA131509, and the Fundação de Amparo à Pesquisa no Estado de São Paulo (FAPESP) 08/54714-6.
PY - 2010/3
Y1 - 2010/3
N2 - Objective: To review the outcomes of a phase II study using laser-induced thermal therapy (LITT) as a palliative treatment for 106 patients with recurrent head and neck tumors. Study Design: Retrospective study. Setting: Tertiary hospital in the United States. Subjects and Methods: The primary endpoints were tumor response and survival. Prognostic values were assessed by the Kaplan-Meier method. Results: The best results were seen in oral cavity tumors, in which mean survival was 29.1 months, as compared to neck tumors (mean 14.4 ± 6.9 months; range 7.5-20.7 months; with a 95% confidence interval). Further analysis showed that clinical factors such as gender, smoking, and alcohol use were not indicators of poor prognosis, whereas neck disease and tumor stage at first treatment were relevant factors. Conclusion: In this study, 40 out of 106 patients treated by LITT remained alive at the end of our follow-up, and a complete response was seen in 24 (22.6%) patients. The highest response rate was seen in oral cavity tumors, which suggests that tumor location at this site may be a predictor of favorable outcome with LITT.
AB - Objective: To review the outcomes of a phase II study using laser-induced thermal therapy (LITT) as a palliative treatment for 106 patients with recurrent head and neck tumors. Study Design: Retrospective study. Setting: Tertiary hospital in the United States. Subjects and Methods: The primary endpoints were tumor response and survival. Prognostic values were assessed by the Kaplan-Meier method. Results: The best results were seen in oral cavity tumors, in which mean survival was 29.1 months, as compared to neck tumors (mean 14.4 ± 6.9 months; range 7.5-20.7 months; with a 95% confidence interval). Further analysis showed that clinical factors such as gender, smoking, and alcohol use were not indicators of poor prognosis, whereas neck disease and tumor stage at first treatment were relevant factors. Conclusion: In this study, 40 out of 106 patients treated by LITT remained alive at the end of our follow-up, and a complete response was seen in 24 (22.6%) patients. The highest response rate was seen in oral cavity tumors, which suggests that tumor location at this site may be a predictor of favorable outcome with LITT.
UR - https://www.scopus.com/pages/publications/77049115480
U2 - 10.1016/j.otohns.2009.11.019
DO - 10.1016/j.otohns.2009.11.019
M3 - Article
C2 - 20172378
AN - SCOPUS:77049115480
SN - 0194-5998
VL - 142
SP - 344
EP - 350
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
IS - 3
ER -