TY - JOUR
T1 - Patient global assessment in psoriatic arthritis
T2 - A multicenter GRAPPA and OMERACT study
AU - Cauli, Alberto
AU - Gladman, Dafna D.
AU - Mathieu, Alessandro
AU - Olivieri, Ignazio
AU - Porru, Giovanni
AU - Tak, Paul P.
AU - Sardu, Claudia
AU - Ujfalussy, Ilona
AU - Scarpa, Raffaele
AU - Marchesoni, Antonio
AU - Taylor, William J.
AU - Spadaro, Antonio
AU - Fernàndez-Sueiro, Jose L.
AU - Salvarani, Carlo
AU - Kalden, Joachim R.
AU - Lubrano, Ennio
AU - Carneiro, Sueli
AU - Desiati, Francesca
AU - Flynn, John A.
AU - D'Angelo, Salvatore
AU - Vacca, Alessandra
AU - Van Kuijk, Arno W.R.
AU - Catanoso, Maria Grazia
AU - Gruenke, Mathias
AU - Peluso, Rosario
AU - Parsons, Wendy J.
AU - Ferrara, Nicola
AU - Contu, Paolo
AU - Helliwell, Philip S.
AU - Mease, Philip J.
PY - 2011/5
Y1 - 2011/5
N2 - Objective. During OMERACT 8, delegates selected patient global assessment (PGA) of disease as a domain to be evaluated in randomized controlled trials in psoriatic arthritis (PsA). This study assessed the reliability of the PGA, measured by means of 0-100 mm visual analog scale (VAS), and the additional utility of separate VAS scales for joints (PJA) and skin (PSA). Methods. In total, 319 consecutive patients with PsA (186 men, 133 women, mean age 51 ± 13 yrs) were enrolled. PGA, PJA, and PSA were administered at enrolment (W0) and after 1 week (W1). Detailed clinical data, including ACR joint count, Psoriasis Area and Severity Index (PASI), and Hospital Anxiety and Depression Scale, were recorded. Results. Comparison of W0 and W1 scores showed no significant variations (intraclass correlation coefficients for PGA 0.87, PJA 0.86, PSA 0.78), demonstrating the reliability of the instrument. PGA scores were not influenced by patient anxiety or depression, but were dependent on PJA and PSA (p = 0.00001). PJA was dependent on the number of swollen and tender joints (p < 0.00001). PSA scores were influenced by the extent of skin psoriasis and by hand skin involvement (p = 0.00001). Joint and skin disease were found not to correlate in terms of disease activity as evidenced by the swollen joint count compared to PASI (r = 0.11) and by the PJA compared to PSA (r = 0.38). Conclusion. PGA assessed by means of VAS is a reliable tool related to joint and skin disease activity. Because joint and skin disease often diverge it is suggested that in some circumstances both PJA and PSA are also assessed. The Journal of Rheumatology
AB - Objective. During OMERACT 8, delegates selected patient global assessment (PGA) of disease as a domain to be evaluated in randomized controlled trials in psoriatic arthritis (PsA). This study assessed the reliability of the PGA, measured by means of 0-100 mm visual analog scale (VAS), and the additional utility of separate VAS scales for joints (PJA) and skin (PSA). Methods. In total, 319 consecutive patients with PsA (186 men, 133 women, mean age 51 ± 13 yrs) were enrolled. PGA, PJA, and PSA were administered at enrolment (W0) and after 1 week (W1). Detailed clinical data, including ACR joint count, Psoriasis Area and Severity Index (PASI), and Hospital Anxiety and Depression Scale, were recorded. Results. Comparison of W0 and W1 scores showed no significant variations (intraclass correlation coefficients for PGA 0.87, PJA 0.86, PSA 0.78), demonstrating the reliability of the instrument. PGA scores were not influenced by patient anxiety or depression, but were dependent on PJA and PSA (p = 0.00001). PJA was dependent on the number of swollen and tender joints (p < 0.00001). PSA scores were influenced by the extent of skin psoriasis and by hand skin involvement (p = 0.00001). Joint and skin disease were found not to correlate in terms of disease activity as evidenced by the swollen joint count compared to PASI (r = 0.11) and by the PJA compared to PSA (r = 0.38). Conclusion. PGA assessed by means of VAS is a reliable tool related to joint and skin disease activity. Because joint and skin disease often diverge it is suggested that in some circumstances both PJA and PSA are also assessed. The Journal of Rheumatology
KW - Assessment measures
KW - Domains
KW - Instruments
KW - Patient global assessment
KW - Psoriatic arthritis
UR - https://www.scopus.com/pages/publications/79955568037
U2 - 10.3899/jrheum.100857
DO - 10.3899/jrheum.100857
M3 - Article
C2 - 21324965
AN - SCOPUS:79955568037
SN - 0315-162X
VL - 38
SP - 898
EP - 903
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 5
ER -