Perception of Treatment Success and Impact on Function with Antibiotics or Appendectomy for Appendicitis: A Randomized Clinical Trial with an Observational Cohort.

Thompson Callie M; Voldal Emily C; Davidson Giana H; Sanchez Sabrina E; Patricia Ayoung-Chee; Jesse Victory; Mary Guiden; Bonnie Bizzell; Jacob Glaser; Christopher Hults; Price Thea P; Nicole Siparsky; Kristin Ohe; Mandell Katherine A; DeUgarte Daniel A; Kaji Amy H; Lisandra Uribe; Kao Lillian S; Mueck Krislynn M; Farhood Farjah; Self Wesley H; Sunday Clark; Drake F Thurston; Katherine Fischkoff; Elizaveta Minko; Joseph Cuschieri; Brett Faine; Skeete Dionne A; Naila Dhanani; Liang Mike K; Anusha Krishnadasan; Talan David A; Erin Fannon; Kessler Larry G; Comstock Bryan A; Heagerty Patrick J; Monsell Sarah E; Lawrence Sarah O; Flum David R; Lavallee Danielle C

Perception of Treatment Success and Impact on Function with Antibiotics or Appendectomy for Appendicitis: A Randomized Clinical Trial with an Observational Cohort.

Thompson Callie M, Voldal Emily C, Davidson Giana H, Sanchez Sabrina E, Patricia Ayoung-Chee, Jesse Victory, Mary Guiden, Bonnie Bizzell, Jacob Glaser, Christopher Hults, Price Thea P, Nicole Siparsky, Kristin Ohe, Mandell Katherine A, DeUgarte Daniel A, Kaji Amy H, Lisandra Uribe, Kao Lillian S, Mueck Krislynn M, Farhood FarjahSelf Wesley H, Sunday Clark, Drake F Thurston, Katherine Fischkoff, Elizaveta Minko, Joseph Cuschieri, Brett Faine, Skeete Dionne A, Naila Dhanani, Liang Mike K, Anusha Krishnadasan, Talan David A, Erin Fannon, Kessler Larry G, Comstock Bryan A, Heagerty Patrick J, Monsell Sarah E, Lawrence Sarah O, Flum David R, Lavallee Danielle C

Research output: Contribution to journal › Article

Abstract

OBJECTIVE: To compare secondary patient reported outcomes of perceptions of treatment success and function for patients treated for appendicitis with appendectomy vs. antibiotics at 30 days.

SUMMARY BACKGROUND DATA: The Comparison of Outcomes of antibiotic Drugs and Appendectomy trial found antibiotics noninferior to appendectomy based on 30-day health status. To address questions about outcomes among participants with lower socioeconomic status, we explored the relationship of sociodemographic and clinical factors and outcomes.

METHODS: We focused on 4 patient reported outcomes at 30 days: high decisional regret, dissatisfaction with treatment, problems performing usual activities, and missing >10 days of work. The randomized (RCT) and observational cohorts were pooled for exploration of baseline factors. The RCT cohort alone was used for comparison of treatments. Logistic regression was used to assess associations.

RESULTS: The pooled cohort contained 2062 participants; 1552 from the RCT. Overall, regret and dissatisfaction were low whereas problems with usual activities and prolonged missed work occurred more frequently. In the RCT, those assigned to antibiotics had more regret (Odd ratios (OR) 2.97, 95% Confidence intervals (CI) 2.05-4.31) and dissatisfaction (OR 1.98, 95%CI 1.25-3.12), and reported less missed work (OR 0.39, 95%CI 0.27-0.56). Factors associated with function outcomes included sociodemographic and clinical variables for both treatment arms. Fewer factors were associated with dissatisfaction and regret.

CONCLUSIONS: Overall, participants reported high satisfaction, low regret, and were frequently able to resume usual activities and return to work. When comparing treatments for appendicitis, no single measure defines success or failure for all people. The reported data may inform discussions regarding the most appropriate treatment for individuals.

TRIAL REGISTRATION: Clinicaltrials.gov Identifier: NCT02800785.

Original language	Undefined/Unknown
Journal	Articles, Abstracts, and Reports
State	Published - Jul 11 2022

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http://digitalcommons.psjhealth.org/publications/6272

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Callie M, T., Emily C, V., Giana H, D., Sabrina E, S., Ayoung-Chee, P., Victory, J., Guiden, M., Bizzell, B., Glaser, J., Hults, C., Thea P, P., Siparsky, N., Ohe, K., Katherine A, M., Daniel A, D., Amy H, K., Uribe, L., Lillian S, K., Krislynn M, M., ... Danielle C, L. (2022). Perception of Treatment Success and Impact on Function with Antibiotics or Appendectomy for Appendicitis: A Randomized Clinical Trial with an Observational Cohort. Articles, Abstracts, and Reports. http://digitalcommons.psjhealth.org/publications/6272

@article{9c810477dd3649b5a6de8464efd1d01f,

title = "Perception of Treatment Success and Impact on Function with Antibiotics or Appendectomy for Appendicitis: A Randomized Clinical Trial with an Observational Cohort.",

abstract = "OBJECTIVE: To compare secondary patient reported outcomes of perceptions of treatment success and function for patients treated for appendicitis with appendectomy vs. antibiotics at 30 days. SUMMARY BACKGROUND DATA: The Comparison of Outcomes of antibiotic Drugs and Appendectomy trial found antibiotics noninferior to appendectomy based on 30-day health status. To address questions about outcomes among participants with lower socioeconomic status, we explored the relationship of sociodemographic and clinical factors and outcomes. METHODS: We focused on 4 patient reported outcomes at 30 days: high decisional regret, dissatisfaction with treatment, problems performing usual activities, and missing >10 days of work. The randomized (RCT) and observational cohorts were pooled for exploration of baseline factors. The RCT cohort alone was used for comparison of treatments. Logistic regression was used to assess associations. RESULTS: The pooled cohort contained 2062 participants; 1552 from the RCT. Overall, regret and dissatisfaction were low whereas problems with usual activities and prolonged missed work occurred more frequently. In the RCT, those assigned to antibiotics had more regret (Odd ratios (OR) 2.97, 95% Confidence intervals (CI) 2.05-4.31) and dissatisfaction (OR 1.98, 95%CI 1.25-3.12), and reported less missed work (OR 0.39, 95%CI 0.27-0.56). Factors associated with function outcomes included sociodemographic and clinical variables for both treatment arms. Fewer factors were associated with dissatisfaction and regret. CONCLUSIONS: Overall, participants reported high satisfaction, low regret, and were frequently able to resume usual activities and return to work. When comparing treatments for appendicitis, no single measure defines success or failure for all people. The reported data may inform discussions regarding the most appropriate treatment for individuals. TRIAL REGISTRATION: Clinicaltrials.gov Identifier: NCT02800785.",

author = "{Callie M}, Thompson and {Emily C}, Voldal and {Giana H}, Davidson and {Sabrina E}, Sanchez and Patricia Ayoung-Chee and Jesse Victory and Mary Guiden and Bonnie Bizzell and Jacob Glaser and Christopher Hults and {Thea P}, Price and Nicole Siparsky and Kristin Ohe and {Katherine A}, Mandell and {Daniel A}, DeUgarte and {Amy H}, Kaji and Lisandra Uribe and {Lillian S}, Kao and {Krislynn M}, Mueck and Farhood Farjah and {Wesley H}, Self and Sunday Clark and {F Thurston}, Drake and Katherine Fischkoff and Elizaveta Minko and Joseph Cuschieri and Brett Faine and {Dionne A}, Skeete and Naila Dhanani and {Mike K}, Liang and Anusha Krishnadasan and {David A}, Talan and Erin Fannon and {Larry G}, Kessler and {Bryan A}, Comstock and {Patrick J}, Heagerty and {Sarah E}, Monsell and {Sarah O}, Lawrence and {David R}, Flum and {Danielle C}, Lavallee",

year = "2022",

month = jul,

day = "11",

language = "Undefined/Unknown",

journal = "Articles, Abstracts, and Reports",

}

Callie M, T, Emily C, V, Giana H, D, Sabrina E, S, Ayoung-Chee, P, Victory, J, Guiden, M, Bizzell, B, Glaser, J, Hults, C, Thea P, P, Siparsky, N, Ohe, K, Katherine A, M, Daniel A, D, Amy H, K, Uribe, L, Lillian S, K, Krislynn M, M, Farjah, F, Wesley H, S, Clark, S, F Thurston, D, Fischkoff, K, Minko, E, Cuschieri, J, Faine, B, Dionne A, S, Dhanani, N, Mike K, L, Krishnadasan, A, David A, T, Fannon, E, Larry G, K, Bryan A, C, Patrick J, H, Sarah E, M, Sarah O, L, David R, F & Danielle C, L 2022, 'Perception of Treatment Success and Impact on Function with Antibiotics or Appendectomy for Appendicitis: A Randomized Clinical Trial with an Observational Cohort.', Articles, Abstracts, and Reports. <http://digitalcommons.psjhealth.org/publications/6272>

TY - JOUR

T1 - Perception of Treatment Success and Impact on Function with Antibiotics or Appendectomy for Appendicitis: A Randomized Clinical Trial with an Observational Cohort.

AU - Callie M, Thompson

AU - Emily C, Voldal

AU - Giana H, Davidson

AU - Sabrina E, Sanchez

AU - Ayoung-Chee, Patricia

AU - Victory, Jesse

AU - Guiden, Mary

AU - Bizzell, Bonnie

AU - Glaser, Jacob

AU - Hults, Christopher

AU - Thea P, Price

AU - Siparsky, Nicole

AU - Ohe, Kristin

AU - Katherine A, Mandell

AU - Daniel A, DeUgarte

AU - Amy H, Kaji

AU - Uribe, Lisandra

AU - Lillian S, Kao

AU - Krislynn M, Mueck

AU - Farjah, Farhood

AU - Wesley H, Self

AU - Clark, Sunday

AU - F Thurston, Drake

AU - Fischkoff, Katherine

AU - Minko, Elizaveta

AU - Cuschieri, Joseph

AU - Faine, Brett

AU - Dionne A, Skeete

AU - Dhanani, Naila

AU - Mike K, Liang

AU - Krishnadasan, Anusha

AU - David A, Talan

AU - Fannon, Erin

AU - Larry G, Kessler

AU - Bryan A, Comstock

AU - Patrick J, Heagerty

AU - Sarah E, Monsell

AU - Sarah O, Lawrence

AU - David R, Flum

AU - Danielle C, Lavallee

PY - 2022/7/11

Y1 - 2022/7/11

N2 - OBJECTIVE: To compare secondary patient reported outcomes of perceptions of treatment success and function for patients treated for appendicitis with appendectomy vs. antibiotics at 30 days. SUMMARY BACKGROUND DATA: The Comparison of Outcomes of antibiotic Drugs and Appendectomy trial found antibiotics noninferior to appendectomy based on 30-day health status. To address questions about outcomes among participants with lower socioeconomic status, we explored the relationship of sociodemographic and clinical factors and outcomes. METHODS: We focused on 4 patient reported outcomes at 30 days: high decisional regret, dissatisfaction with treatment, problems performing usual activities, and missing >10 days of work. The randomized (RCT) and observational cohorts were pooled for exploration of baseline factors. The RCT cohort alone was used for comparison of treatments. Logistic regression was used to assess associations. RESULTS: The pooled cohort contained 2062 participants; 1552 from the RCT. Overall, regret and dissatisfaction were low whereas problems with usual activities and prolonged missed work occurred more frequently. In the RCT, those assigned to antibiotics had more regret (Odd ratios (OR) 2.97, 95% Confidence intervals (CI) 2.05-4.31) and dissatisfaction (OR 1.98, 95%CI 1.25-3.12), and reported less missed work (OR 0.39, 95%CI 0.27-0.56). Factors associated with function outcomes included sociodemographic and clinical variables for both treatment arms. Fewer factors were associated with dissatisfaction and regret. CONCLUSIONS: Overall, participants reported high satisfaction, low regret, and were frequently able to resume usual activities and return to work. When comparing treatments for appendicitis, no single measure defines success or failure for all people. The reported data may inform discussions regarding the most appropriate treatment for individuals. TRIAL REGISTRATION: Clinicaltrials.gov Identifier: NCT02800785.

AB - OBJECTIVE: To compare secondary patient reported outcomes of perceptions of treatment success and function for patients treated for appendicitis with appendectomy vs. antibiotics at 30 days. SUMMARY BACKGROUND DATA: The Comparison of Outcomes of antibiotic Drugs and Appendectomy trial found antibiotics noninferior to appendectomy based on 30-day health status. To address questions about outcomes among participants with lower socioeconomic status, we explored the relationship of sociodemographic and clinical factors and outcomes. METHODS: We focused on 4 patient reported outcomes at 30 days: high decisional regret, dissatisfaction with treatment, problems performing usual activities, and missing >10 days of work. The randomized (RCT) and observational cohorts were pooled for exploration of baseline factors. The RCT cohort alone was used for comparison of treatments. Logistic regression was used to assess associations. RESULTS: The pooled cohort contained 2062 participants; 1552 from the RCT. Overall, regret and dissatisfaction were low whereas problems with usual activities and prolonged missed work occurred more frequently. In the RCT, those assigned to antibiotics had more regret (Odd ratios (OR) 2.97, 95% Confidence intervals (CI) 2.05-4.31) and dissatisfaction (OR 1.98, 95%CI 1.25-3.12), and reported less missed work (OR 0.39, 95%CI 0.27-0.56). Factors associated with function outcomes included sociodemographic and clinical variables for both treatment arms. Fewer factors were associated with dissatisfaction and regret. CONCLUSIONS: Overall, participants reported high satisfaction, low regret, and were frequently able to resume usual activities and return to work. When comparing treatments for appendicitis, no single measure defines success or failure for all people. The reported data may inform discussions regarding the most appropriate treatment for individuals. TRIAL REGISTRATION: Clinicaltrials.gov Identifier: NCT02800785.

M3 - Article

JO - Articles, Abstracts, and Reports

JF - Articles, Abstracts, and Reports

ER -