Pertuzumab Plus Trastuzumab in Patients With Biliary Tract Cancer With

Timothy L Cannon, Michael Rothe, Pam K Mangat, Elizabeth Garrett-Mayer, Vi K Chiu, Jimmy Hwang, Namrata Vijayvergia, Olatunji B Alese, Elie G Dib, Herbert L Duvivier, Kelsey A Klute, Vaibhav Sahai, Eugene R Ahn, Pablo Bedano, Deepti Behl, Sarah Sinclair, Ramya Thota, Walter Urba, Eddy S Yang, Gina N GranthamDominique C Hinshaw, Abigail Gregory, Susan Halabi, Richard L Schilsky

Research output: Contribution to journalArticle

Abstract

PURPOSE: Targeted Agent and Profiling Utilization Registry is a phase II basket trial evaluating the antitumor activity of commercially available targeted agents in patients with advanced cancer and genomic alterations known to be drug targets. Results of a cohort of patients with biliary tract cancer (BTC) with

METHODS: Eligible patients had advanced BTC, measurable disease (RECIST v1.1), Eastern Cooperative Oncology Group performance status 0-2, adequate organ function, tumors with

RESULTS: Twenty-nine patients were enrolled from February 2017 to January 2022, and all had advanced BTC with an

CONCLUSION: Pertuzumab plus trastuzumab met prespecified criteria to declare a signal of activity in patients with BTC and

Original languageUndefined/Unknown
JournalArticles, Abstracts, and Reports
StatePublished - May 15 2024

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