TY - JOUR
T1 - Plasma granulysin concentrations and preeclampsia risk
AU - Qiu, Chunfang
AU - Saito, Shigeru
AU - Sakai, Masatoshi
AU - Ogawa, Kazuyuki
AU - Nagata, Kinya
AU - Williams, Michelle A.
N1 - Funding Information:
This research was supported in part by awards from the National Institutes of Health (HD/HL R01 34888 and HD/HL R01 32562.). This research was also supported by grants from the Ministry of Education, Culture, Sports, Science and Technology, Japan [grant-in Aid for Scientific Research (B)-17390447 and (C)-18591797 and Grant-in-Aid for Exploratory Research 18659482].
PY - 2006/10
Y1 - 2006/10
N2 - Objective: Epidemiological, clinical and histological data suggest intriguing similarities between preeclampsia and graft-host-rejection. Granulysin, a novel biomarker of overall cellular immunity, is secreted by natural killer cells and cytotoxic T lymphocytes, which are associated with graft-host-rejection. Plasma granulysin was elevated in Japanese preeclamptic women. Design and Methods: 50 preeclampsia cases and 50 normotensive controls (USA) were studied. Plasma granulysin at delivery was determined using enzyme immunoassay. Logistic regression procedures were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results: Granulysin were elevated in preeclampsia cases compared with controls (3.01 ± 0.18 vs. 2.22 ± 0.14 ng/mL, p < 0.01). After adjusting for age, body-mass-index and race, women with higher granulysin concentrations (≥ 1.89 ng/mL) experienced a 2.9-fold (95%CI 1.1-7.8) increased preeclampsia risk compared with women with lower granulysin (< 1.89 ng/mL). Conclusions: These data offer further evidence of a predominant Th1 immune status associated with preeclampsia. Prospective studies are needed to determine whether granulysin is elevated early in pregnancy.
AB - Objective: Epidemiological, clinical and histological data suggest intriguing similarities between preeclampsia and graft-host-rejection. Granulysin, a novel biomarker of overall cellular immunity, is secreted by natural killer cells and cytotoxic T lymphocytes, which are associated with graft-host-rejection. Plasma granulysin was elevated in Japanese preeclamptic women. Design and Methods: 50 preeclampsia cases and 50 normotensive controls (USA) were studied. Plasma granulysin at delivery was determined using enzyme immunoassay. Logistic regression procedures were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results: Granulysin were elevated in preeclampsia cases compared with controls (3.01 ± 0.18 vs. 2.22 ± 0.14 ng/mL, p < 0.01). After adjusting for age, body-mass-index and race, women with higher granulysin concentrations (≥ 1.89 ng/mL) experienced a 2.9-fold (95%CI 1.1-7.8) increased preeclampsia risk compared with women with lower granulysin (< 1.89 ng/mL). Conclusions: These data offer further evidence of a predominant Th1 immune status associated with preeclampsia. Prospective studies are needed to determine whether granulysin is elevated early in pregnancy.
KW - Granulysin
KW - Preeclampsia
UR - https://www.scopus.com/pages/publications/33748967570
U2 - 10.1016/j.clinbiochem.2006.07.008
DO - 10.1016/j.clinbiochem.2006.07.008
M3 - Article
C2 - 16973142
AN - SCOPUS:33748967570
SN - 0009-9120
VL - 39
SP - 1016
EP - 1021
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 10
ER -