Abstract
In order to clarify the mechanisms of cancer metastasis after surgery, we focused on hepatocyte growth factor (HGF) from the aspect of local concentrations of HGF after surgery and the effect of HGF on cancer cell growth and invasion. All the cancer patients who underwent surgical resections showed the presence of local HGF over 1 ng/ml concentrations after surgery. In vitro invasion of colon cancer cells was significantly augmented by HGF at concentrations over 1 ng/ml in a dose dependent manner. In addition, production of MMP-1 and MMP-2 by colon cancer cells was significantly enhanced by HGF. These HGF effects were significantly inhibited by IL-4. The results suggest that local HGF may play a role in cancer metastasis after surgery. IL-4 is a potent inhibitor of HGF-induced invasion and metastasis-related functions of human colon carcinoma cells.
| Original language | English |
|---|---|
| Pages (from-to) | 981-985 |
| Number of pages | 5 |
| Journal | Biotherapy |
| Volume | 11 |
| Issue number | 9 |
| State | Published - 1997 |
Keywords
- Hepatocyte growth factor
- IL-4
- Metastasis
- Surgery
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