Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL: “What's Past Is Prologue” (Shakespeare)

Anthony R. Mato; Matthew S. Davids; Jeff Sharman; Lindsey E. Roeker; Neil Kay; Arnon P. Kater; Kerry Rogers; Meghan C. Thompson; Joanna Rhodes; Andre Goy; Alan Skarbnik; Stephen J. Schuster; Constantine S. Tam; Toby A. Eyre; Susan O'Brien; Chadi Nabhan; Nicole Lamanna; Clare Sun; Mazyar Shadman; John M. Pagel; Chaitra Ujjani; Danielle Brander; Catherine C. Coombs; Nitin Jain; Chan Y. Cheah; Jennifer R. Brown; John F. Seymour; Jennifer A. Woyach

doi:10.1158/1078-0432.CCR-21-1237

Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL: “What's Past Is Prologue” (Shakespeare)

Anthony R. Mato, Matthew S. Davids, Jeff Sharman, Lindsey E. Roeker, Neil Kay, Arnon P. Kater, Kerry Rogers, Meghan C. Thompson, Joanna Rhodes, Andre Goy, Alan Skarbnik, Stephen J. Schuster, Constantine S. Tam, Toby A. Eyre, Susan O'Brien, Chadi Nabhan, Nicole Lamanna, Clare Sun, Mazyar Shadman, John M. PagelChaitra Ujjani, Danielle Brander, Catherine C. Coombs, Nitin Jain, Chan Y. Cheah, Jennifer R. Brown, John F. Seymour, Jennifer A. Woyach

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13 Scopus citations

Abstract

The management of chronic lymphocytic leukemia (CLL) has undergone unprecedented changes over the last decade. Modern targeted therapies are incorporated into clinical practice. Unfortunately, patients have begun to develop resistance or intolerance to multiple classes. Symptomatic patients previously treated with a BTK inhibitor (BTKi) and venetoclax represent a new and rapidly growing unmet need in CLL. Here, we define unmet needs in a modern treatment context. We also critically review the literature for PI3K inhibitors and chemoimmunotherapy and lack of data to support their utility following BTKis and venetoclax. Finally, we suggest opportunities to ensure the continued innovation for patients with CLL.

Original language	English
Pages (from-to)	603-608
Number of pages	6
Journal	Clinical Cancer Research
Volume	28
Issue number	4
DOIs	https://doi.org/10.1158/1078-0432.CCR-21-1237
State	Published - Feb 15 2022

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Mato, A. R., Davids, M. S., Sharman, J., Roeker, L. E., Kay, N., Kater, A. P., Rogers, K., Thompson, M. C., Rhodes, J., Goy, A., Skarbnik, A., Schuster, S. J., Tam, C. S., Eyre, T. A., O'Brien, S., Nabhan, C., Lamanna, N., Sun, C., Shadman, M., ... Woyach, J. A. (2022). Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL: “What's Past Is Prologue” (Shakespeare). Clinical Cancer Research, 28(4), 603-608. https://doi.org/10.1158/1078-0432.CCR-21-1237

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title = "Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL: “What's Past Is Prologue” (Shakespeare)",

abstract = "The management of chronic lymphocytic leukemia (CLL) has undergone unprecedented changes over the last decade. Modern targeted therapies are incorporated into clinical practice. Unfortunately, patients have begun to develop resistance or intolerance to multiple classes. Symptomatic patients previously treated with a BTK inhibitor (BTKi) and venetoclax represent a new and rapidly growing unmet need in CLL. Here, we define unmet needs in a modern treatment context. We also critically review the literature for PI3K inhibitors and chemoimmunotherapy and lack of data to support their utility following BTKis and venetoclax. Finally, we suggest opportunities to ensure the continued innovation for patients with CLL.",

author = "Mato, {Anthony R.} and Davids, {Matthew S.} and Jeff Sharman and Roeker, {Lindsey E.} and Neil Kay and Kater, {Arnon P.} and Kerry Rogers and Thompson, {Meghan C.} and Joanna Rhodes and Andre Goy and Alan Skarbnik and Schuster, {Stephen J.} and Tam, {Constantine S.} and Eyre, {Toby A.} and Susan O'Brien and Chadi Nabhan and Nicole Lamanna and Clare Sun and Mazyar Shadman and Pagel, {John M.} and Chaitra Ujjani and Danielle Brander and Coombs, {Catherine C.} and Nitin Jain and Cheah, {Chan Y.} and Brown, {Jennifer R.} and Seymour, {John F.} and Woyach, {Jennifer A.}",

note = "Publisher Copyright: {\textcopyright} 2021 American Association for Cancer Research",

year = "2022",

month = feb,

day = "15",

doi = "10.1158/1078-0432.CCR-21-1237",

language = "English",

volume = "28",

pages = "603--608",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

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Mato, AR, Davids, MS, Sharman, J, Roeker, LE, Kay, N, Kater, AP, Rogers, K, Thompson, MC, Rhodes, J, Goy, A, Skarbnik, A, Schuster, SJ, Tam, CS, Eyre, TA, O'Brien, S, Nabhan, C, Lamanna, N, Sun, C, Shadman, M, Pagel, JM, Ujjani, C, Brander, D, Coombs, CC, Jain, N, Cheah, CY, Brown, JR, Seymour, JF & Woyach, JA 2022, 'Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL: “What's Past Is Prologue” (Shakespeare)', Clinical Cancer Research, vol. 28, no. 4, pp. 603-608. https://doi.org/10.1158/1078-0432.CCR-21-1237

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T1 - Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL

T2 - “What's Past Is Prologue” (Shakespeare)

AU - Mato, Anthony R.

AU - Davids, Matthew S.

AU - Sharman, Jeff

AU - Roeker, Lindsey E.

AU - Kay, Neil

AU - Kater, Arnon P.

AU - Rogers, Kerry

AU - Thompson, Meghan C.

AU - Rhodes, Joanna

AU - Goy, Andre

AU - Skarbnik, Alan

AU - Schuster, Stephen J.

AU - Tam, Constantine S.

AU - Eyre, Toby A.

AU - O'Brien, Susan

AU - Nabhan, Chadi

AU - Lamanna, Nicole

AU - Sun, Clare

AU - Shadman, Mazyar

AU - Pagel, John M.

AU - Ujjani, Chaitra

AU - Brander, Danielle

AU - Coombs, Catherine C.

AU - Jain, Nitin

AU - Cheah, Chan Y.

AU - Brown, Jennifer R.

AU - Seymour, John F.

AU - Woyach, Jennifer A.

PY - 2022/2/15

Y1 - 2022/2/15

N2 - The management of chronic lymphocytic leukemia (CLL) has undergone unprecedented changes over the last decade. Modern targeted therapies are incorporated into clinical practice. Unfortunately, patients have begun to develop resistance or intolerance to multiple classes. Symptomatic patients previously treated with a BTK inhibitor (BTKi) and venetoclax represent a new and rapidly growing unmet need in CLL. Here, we define unmet needs in a modern treatment context. We also critically review the literature for PI3K inhibitors and chemoimmunotherapy and lack of data to support their utility following BTKis and venetoclax. Finally, we suggest opportunities to ensure the continued innovation for patients with CLL.

AB - The management of chronic lymphocytic leukemia (CLL) has undergone unprecedented changes over the last decade. Modern targeted therapies are incorporated into clinical practice. Unfortunately, patients have begun to develop resistance or intolerance to multiple classes. Symptomatic patients previously treated with a BTK inhibitor (BTKi) and venetoclax represent a new and rapidly growing unmet need in CLL. Here, we define unmet needs in a modern treatment context. We also critically review the literature for PI3K inhibitors and chemoimmunotherapy and lack of data to support their utility following BTKis and venetoclax. Finally, we suggest opportunities to ensure the continued innovation for patients with CLL.

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AN - SCOPUS:85124992369

SN - 1078-0432

VL - 28

SP - 603

EP - 608

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 4

ER -

Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL: “What's Past Is Prologue” (Shakespeare)

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