Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report

Jason D. Goldman; Kai Wang; Katharina Röltgen; Sandra C.A. Nielsen; Jared C. Roach; Samia N. Naccache; Fan Yang; Oliver F. Wirz; Kathryn E. Yost; Ji Yeun Lee; Kelly Chun; Terri Wrin; Christos J. Petropoulos; Inyoul Lee; Shannon Fallen; Paula M. Manner; Julie A. Wallick; Heather A. Algren; Kim M. Murray; Jennifer Hadlock; Daniel Chen; Chengzhen L. Dai; Dan Yuan; Yapeng Su; Joshua Jeharajah; William R. Berrington; George P. Pappas; Sonam T. Nyatsatsang; Alexander L. Greninger; Ansuman T. Satpathy; John S. Pauk; Scott D. Boyd; James R. Heath

doi:10.3390/vaccines11010005

Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report

Jason D. Goldman, Kai Wang, Katharina Röltgen, Sandra C.A. Nielsen, Jared C. Roach, Samia N. Naccache, Fan Yang, Oliver F. Wirz, Kathryn E. Yost, Ji Yeun Lee, Kelly Chun, Terri Wrin, Christos J. Petropoulos, Inyoul Lee, Shannon Fallen, Paula M. Manner, Julie A. Wallick, Heather A. Algren, Kim M. Murray, Jennifer HadlockDaniel Chen, Chengzhen L. Dai, Dan Yuan, Yapeng Su, Joshua Jeharajah, William R. Berrington, George P. Pappas, Sonam T. Nyatsatsang, Alexander L. Greninger, Ansuman T. Satpathy, John S. Pauk, Scott D. Boyd, James R. Heath

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Recovery from COVID-19 is associated with production of anti-SARS-CoV-2 antibodies, but it is uncertain whether these confer immunity. We describe viral RNA shedding duration in hospitalized patients and identify patients with recurrent shedding. We sequenced viruses from two distinct episodes of symptomatic COVID-19 separated by 144 days in a single patient, to conclusively describe reinfection with a different strain harboring the spike variant D614G. This case of reinfection was one of the first cases of reinfection reported in 2020. With antibody, B cell and T cell analytics, we show correlates of adaptive immunity at reinfection, including a differential response in neutralizing antibodies to a D614G pseudovirus. Finally, we discuss implications for vaccine programs and begin to define benchmarks for protection against reinfection from SARS-CoV-2.

Original language	English
Article number	5
Journal	Vaccines
Volume	11
Issue number	1
DOIs	https://doi.org/10.3390/vaccines11010005
State	Published - Jan 2023

Keywords

COVID-19
SARS-CoV-2
humoral immunity
reinfection

Access to Document

10.3390/vaccines11010005

Cite this

Goldman, J. D., Wang, K., Röltgen, K., Nielsen, S. C. A., Roach, J. C., Naccache, S. N., Yang, F., Wirz, O. F., Yost, K. E., Lee, J. Y., Chun, K., Wrin, T., Petropoulos, C. J., Lee, I., Fallen, S., Manner, P. M., Wallick, J. A., Algren, H. A., Murray, K. M., ... Heath, J. R. (2023). Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report. Vaccines, 11(1), Article 5. https://doi.org/10.3390/vaccines11010005

@article{9e9f45803dce4d4ba7265ba6b17eb740,

title = "Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report",

abstract = "Recovery from COVID-19 is associated with production of anti-SARS-CoV-2 antibodies, but it is uncertain whether these confer immunity. We describe viral RNA shedding duration in hospitalized patients and identify patients with recurrent shedding. We sequenced viruses from two distinct episodes of symptomatic COVID-19 separated by 144 days in a single patient, to conclusively describe reinfection with a different strain harboring the spike variant D614G. This case of reinfection was one of the first cases of reinfection reported in 2020. With antibody, B cell and T cell analytics, we show correlates of adaptive immunity at reinfection, including a differential response in neutralizing antibodies to a D614G pseudovirus. Finally, we discuss implications for vaccine programs and begin to define benchmarks for protection against reinfection from SARS-CoV-2.",

keywords = "COVID-19, SARS-CoV-2, humoral immunity, reinfection",

author = "Goldman, {Jason D.} and Kai Wang and Katharina R{\"o}ltgen and Nielsen, {Sandra C.A.} and Roach, {Jared C.} and Naccache, {Samia N.} and Fan Yang and Wirz, {Oliver F.} and Yost, {Kathryn E.} and Lee, {Ji Yeun} and Kelly Chun and Terri Wrin and Petropoulos, {Christos J.} and Inyoul Lee and Shannon Fallen and Manner, {Paula M.} and Wallick, {Julie A.} and Algren, {Heather A.} and Murray, {Kim M.} and Jennifer Hadlock and Daniel Chen and Dai, {Chengzhen L.} and Dan Yuan and Yapeng Su and Joshua Jeharajah and Berrington, {William R.} and Pappas, {George P.} and Nyatsatsang, {Sonam T.} and Greninger, {Alexander L.} and Satpathy, {Ansuman T.} and Pauk, {John S.} and Boyd, {Scott D.} and Heath, {James R.}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2023",

month = jan,

doi = "10.3390/vaccines11010005",

language = "English",

volume = "11",

journal = "Vaccines",

issn = "2076-393X",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "1",

}

Goldman, JD, Wang, K, Röltgen, K, Nielsen, SCA, Roach, JC, Naccache, SN, Yang, F, Wirz, OF, Yost, KE, Lee, JY, Chun, K, Wrin, T, Petropoulos, CJ, Lee, I, Fallen, S, Manner, PM, Wallick, JA , Algren, HA, Murray, KM, Hadlock, J, Chen, D, Dai, CL, Yuan, D, Su, Y, Jeharajah, J, Berrington, WR, Pappas, GP, Nyatsatsang, ST, Greninger, AL, Satpathy, AT, Pauk, JS, Boyd, SD & Heath, JR 2023, 'Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report', Vaccines, vol. 11, no. 1, 5. https://doi.org/10.3390/vaccines11010005

TY - JOUR

T1 - Reinfection with SARS-CoV-2 and Waning Humoral Immunity

T2 - A Case Report

AU - Goldman, Jason D.

AU - Wang, Kai

AU - Röltgen, Katharina

AU - Nielsen, Sandra C.A.

AU - Roach, Jared C.

AU - Naccache, Samia N.

AU - Yang, Fan

AU - Wirz, Oliver F.

AU - Yost, Kathryn E.

AU - Lee, Ji Yeun

AU - Chun, Kelly

AU - Wrin, Terri

AU - Petropoulos, Christos J.

AU - Lee, Inyoul

AU - Fallen, Shannon

AU - Manner, Paula M.

AU - Wallick, Julie A.

AU - Algren, Heather A.

AU - Murray, Kim M.

AU - Hadlock, Jennifer

AU - Chen, Daniel

AU - Dai, Chengzhen L.

AU - Yuan, Dan

AU - Su, Yapeng

AU - Jeharajah, Joshua

AU - Berrington, William R.

AU - Pappas, George P.

AU - Nyatsatsang, Sonam T.

AU - Greninger, Alexander L.

AU - Satpathy, Ansuman T.

AU - Pauk, John S.

AU - Boyd, Scott D.

AU - Heath, James R.

PY - 2023/1

Y1 - 2023/1

N2 - Recovery from COVID-19 is associated with production of anti-SARS-CoV-2 antibodies, but it is uncertain whether these confer immunity. We describe viral RNA shedding duration in hospitalized patients and identify patients with recurrent shedding. We sequenced viruses from two distinct episodes of symptomatic COVID-19 separated by 144 days in a single patient, to conclusively describe reinfection with a different strain harboring the spike variant D614G. This case of reinfection was one of the first cases of reinfection reported in 2020. With antibody, B cell and T cell analytics, we show correlates of adaptive immunity at reinfection, including a differential response in neutralizing antibodies to a D614G pseudovirus. Finally, we discuss implications for vaccine programs and begin to define benchmarks for protection against reinfection from SARS-CoV-2.

AB - Recovery from COVID-19 is associated with production of anti-SARS-CoV-2 antibodies, but it is uncertain whether these confer immunity. We describe viral RNA shedding duration in hospitalized patients and identify patients with recurrent shedding. We sequenced viruses from two distinct episodes of symptomatic COVID-19 separated by 144 days in a single patient, to conclusively describe reinfection with a different strain harboring the spike variant D614G. This case of reinfection was one of the first cases of reinfection reported in 2020. With antibody, B cell and T cell analytics, we show correlates of adaptive immunity at reinfection, including a differential response in neutralizing antibodies to a D614G pseudovirus. Finally, we discuss implications for vaccine programs and begin to define benchmarks for protection against reinfection from SARS-CoV-2.

KW - COVID-19

KW - SARS-CoV-2

KW - humoral immunity

KW - reinfection

UR - http://www.scopus.com/inward/record.url?scp=85146763751&partnerID=8YFLogxK

U2 - 10.3390/vaccines11010005

DO - 10.3390/vaccines11010005

M3 - Article

C2 - 36679852

AN - SCOPUS:85146763751

SN - 2076-393X

VL - 11

JO - Vaccines

JF - Vaccines

IS - 1

M1 - 5

ER -

Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this