Renal transport of organic acids and bases in aminoglycoside nephrotoxicity

W. M. Bennett; C. E. Plamp; R. A. Parker; D. N. Gilbert; D. C. Houghton; G. A. Porter

doi:10.1128/AAC.16.2.231

Renal transport of organic acids and bases in aminoglycoside nephrotoxicity

W. M. Bennett
, C. E. Plamp
, R. A. Parker
, D. N. Gilbert
, D. C. Houghton
, G. A. Porter

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The effects of aminoglycoside antibiotics on the transport of p-aminohippurate and N-methylnicotinamide was measured in renal cortical slices of male Fischer rats. The p-aminohippurate transport pattern of early stimulation followed by late suppression appears to be characteristic of aminoglycosides which produce overt nephrotoxicity. In this rat model, neomycin is more nephrotoxic than gentamicin, which is more nephrotoxic than tobramycin.

Original language	English
Pages (from-to)	231-233
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	16
Issue number	2
DOIs	https://doi.org/10.1128/AAC.16.2.231
State	Published - 1979

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title = "Renal transport of organic acids and bases in aminoglycoside nephrotoxicity",

abstract = "The effects of aminoglycoside antibiotics on the transport of p-aminohippurate and N-methylnicotinamide was measured in renal cortical slices of male Fischer rats. The p-aminohippurate transport pattern of early stimulation followed by late suppression appears to be characteristic of aminoglycosides which produce overt nephrotoxicity. In this rat model, neomycin is more nephrotoxic than gentamicin, which is more nephrotoxic than tobramycin.",

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AU - Bennett, W. M.

AU - Plamp, C. E.

AU - Parker, R. A.

AU - Gilbert, D. N.

AU - Houghton, D. C.

AU - Porter, G. A.

PY - 1979

Y1 - 1979

N2 - The effects of aminoglycoside antibiotics on the transport of p-aminohippurate and N-methylnicotinamide was measured in renal cortical slices of male Fischer rats. The p-aminohippurate transport pattern of early stimulation followed by late suppression appears to be characteristic of aminoglycosides which produce overt nephrotoxicity. In this rat model, neomycin is more nephrotoxic than gentamicin, which is more nephrotoxic than tobramycin.

AB - The effects of aminoglycoside antibiotics on the transport of p-aminohippurate and N-methylnicotinamide was measured in renal cortical slices of male Fischer rats. The p-aminohippurate transport pattern of early stimulation followed by late suppression appears to be characteristic of aminoglycosides which produce overt nephrotoxicity. In this rat model, neomycin is more nephrotoxic than gentamicin, which is more nephrotoxic than tobramycin.

UR - https://www.scopus.com/pages/publications/0018747371

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DO - 10.1128/AAC.16.2.231

M3 - Article

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AN - SCOPUS:0018747371

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EP - 233

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 2

ER -

Renal transport of organic acids and bases in aminoglycoside nephrotoxicity

Abstract

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