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The linear relationship between transcranial doppler pulsatility indices and intracranial pressure is influenced by traumatic brain injury and vasospasm

  • Thomas C. Glenn
  • , Arun K. Sherma
  • , David L. McArthur
  • , Xiao Hu
  • , Christopher R. Hanuscin
  • , Mehjabeen S. Furreedan
  • , David A. Hovda
  • , Paul M. Vespa
  • , Neil A. Martin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

13 Scopus citations

Abstract

The pulsatility index (PI) and the intracranial-pressure (ICP) may or may not be correlated; the evidence to date differs widely. A study of multiple measures of PI and the corresponding ICP in patients with severe traumatic brain injury (TBI) showed that some of the relationships were moderately strong when calculated as conventional Pearson correlation coefficients. However, that method makes no adjustment of any kind for statistical outliers in the data. With the TBI patients demonstrating a large fraction of skewed measurements, a set of robust correlations were calculated that demonstrated that the apparent relationships between PI and ICP were entirely attributable to the statistical outliers. We conclude that the fundamental relationship of PI to ICP is weakly positive at best.

Original languageEnglish
Title of host publicationIntracranial Pressure and Brain Monitoring XIV
PublisherSpringer-Verlag Wien
Pages11-15
Number of pages5
ISBN (Print)9783709109557
DOIs
StatePublished - 2012

Publication series

NameActa Neurochirurgica, Supplementum
Volume114
ISSN (Print)0065-1419
ISSN (Electronic)0001-6268

Keywords

  • Craniectomy
  • Intracranial pressure
  • Pulsatility index
  • Transcranial Doppler
  • Traumatic brain injury
  • Vasospasm

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