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About
William L. Redmond, PhD is a Member (Full Professor) and Director of the Immune Monitoring Laboratory at the Earle A. Chiles Research Institute (EACRI) at the Providence Cancer Institute. Dr. Redmond’s research seeks to elucidate the mechanisms by which various therapies including immune checkpoint blockade, T cell agonists, and common gamma chain cytokines (e.g., IL-2) can synergize with novel therapies to augment anti-tumor immunity. Furthermore, he seeks to identify biomarkers of response to treatment that may provide insight into the mechanisms by which immunotherapy improve outcomes in patients with advanced malignancies. Dr. Redmond has extensive experience with murine tumor models and, as Director, EACRI Immune Monitoring Laboratory, oversees translational research efforts seeking to develop and implement state-of-the-art immune profiling assays for the evaluation of anti-tumor immunity in cancer patients. This includes analysis of peripheral blood, serum, and tumor tissue by multi-parameter flow cytometry, multiplex immunohistochemistry, and next-gen sequencing including single-cell RNA-seq. Dr. Redmond expertise in tumor immunology has led to numerous peer-reviewed publications and grant support from agencies including the NIH/NCI, Susan G. Komen, Prostate Cancer Foundation, American Cancer Society, and V Foundation.
Education/Academic qualification
The Scripps Research Institute
… → 2004
University of California, Davis
… → 1997
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Collaborations and top research areas from the last five years
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Phase II Clinical Development of Galectin-3 Inhibition and Anti-PD-1: Immune Monitoring and Tumor Response
Curti, B. (PI) & Redmond, W. (CoPI)
08/2/21 → 07/31/25
Project: Research
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Vitamin E analog-induced tumor autophagy to enhance tumor immunity
Redmond, W. (PI)
American Institute for Cancer Research
01/1/14 → …
Project: Research
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Elucidate the mechanisms regulating prostate cancer immunotherapy
Redmond, W. (PI)
V Foundation for Cancer Research
01/1/11 → …
Project: Research
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Elucidating the role of intratumoral microbiota on immunotherapy efficacy
Redmond, W. (PI) & Redmond, W. (PI)
07/12/21 → 06/30/23
Project: Research
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Ipilimumab plus a galectin-3 inhibitor for metastatic melanoma
Curti, B. (PI) & Redmond, W. (CoPI)
07/6/15 → 06/30/16
Project: Research
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Current landscape and future prospects of interleukin-2 receptor (IL-2R) agonists in cancer immunotherapy
Tanigawa, K. & Redmond, W. L., 2025, In: OncoImmunology. 14, 1, 2452654.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
INBRX-106: a hexavalent OX40 agonist that drives superior antitumor responses via optimized receptor clustering
Holay, N., Yadav, R., Ahn, S. J., Kasiewicz, M. J., Polovina, A., Rolig, A. S., Staebler, T., Becklund, B., Simons, N. D., Koguchi, Y., Eckelman, B. P., De Durana, Y. D. & Redmond, W. L., May 21 2025, In: Journal for ImmunoTherapy of Cancer. 13, 5, e011524.Research output: Contribution to journal › Article › peer-review
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SITC vision: Opportunities for deeper understanding of mechanisms of anti-tumor activity, toxicity, and resistance to optimize cancer immunotherapy
Sullivan, R. J., Cillo, A. R., Ferris, R. L., Jenkins, R. W., Kluger, H. M., Kok, M., Lipson, E. J., Paruzzo, L., Redmond, W. L., Ruella, M., Schalper, K. A., Thommen, D. S., Tolley, K., Yarchoan, M. & Garnett-Benson, C., Jun 25 2025, In: Journal for ImmunoTherapy of Cancer. 13, 6, e011929.Research output: Contribution to journal › Article › peer-review
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The response to anti–PD-1 and anti–LAG-3 checkpoint blockade is associated with regulatory T cell reprogramming
Rolig, A. S., Peng, X., Sturgill, E. R., Holay, N., Kasiewicz, M., Mick, C., McGee, G. H., Miller, W., Koguchi, Y., Kaufmann, J., Yanamandra, N., Griffin, S., Smothers, J., Adamow, M., Lee, J., Shen, R., Callahan, M. K. & Redmond, W. L., Apr 9 2025, In: Science Translational Medicine. 17, 793, eadk3702.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells
Madan, E., Palma, A. M., Vudatha, V., Kumar, A., Bhoopathi, P., Wilhelm, J., Bernas, T., Martin, P. C., Bilolikar, G., Gogna, A., Peixoto, M. L., Dreier, I., Araujo, T. F., Garre, E., Gustafsson, A., Dorayappan, K. D. P., Mamidi, N., Sun, Z., Yekelchyk, M. & Accardi, D. & 90 others, , 2024, (Accepted/In press) In: Nature Biotechnology. e13714.Research output: Contribution to journal › Article › peer-review
7 Scopus citations