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About
William L. Redmond, PhD is a Member (Full Professor) and Director of the Immune Monitoring Laboratory at the Earle A. Chiles Research Institute (EACRI) at the Providence Cancer Institute. Dr. Redmond’s research seeks to elucidate the mechanisms by which various therapies including immune checkpoint blockade, T cell agonists, and common gamma chain cytokines (e.g., IL-2) can synergize with novel therapies to augment anti-tumor immunity. Furthermore, he seeks to identify biomarkers of response to treatment that may provide insight into the mechanisms by which immunotherapy improve outcomes in patients with advanced malignancies. Dr. Redmond has extensive experience with murine tumor models and, as Director, EACRI Immune Monitoring Laboratory, oversees translational research efforts seeking to develop and implement state-of-the-art immune profiling assays for the evaluation of anti-tumor immunity in cancer patients. This includes analysis of peripheral blood, serum, and tumor tissue by multi-parameter flow cytometry, multiplex immunohistochemistry, and next-gen sequencing including single-cell RNA-seq. Dr. Redmond expertise in tumor immunology has led to numerous peer-reviewed publications and grant support from agencies including the NIH/NCI, Susan G. Komen, Prostate Cancer Foundation, American Cancer Society, and V Foundation.
Education/Academic qualification
The Scripps Research Institute
… → 2004
University of California, Davis
… → 1997
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Collaborations and top research areas from the last five years
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Phase II Clinical Development of Galectin-3 Inhibition and Anti-PD-1: Immune Monitoring and Tumor Response
08/2/21 → 07/31/24
Project: Research
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Elucidate the mechanisms regulating prostate cancer immunotherapy
V Foundation for Cancer Research
01/1/11 → …
Project: Research
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Elucidating the role of intratumoral microbiota on immunotherapy efficacy
07/12/21 → 06/30/23
Project: Research
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A phase Ib trial of pembrolizumab plus paclitaxel or flat-dose capecitabine in 1st/2nd line metastatic triple-negative breast cancer
Page, D. B., Pucilowska, J., Chun, B., Kim, I., Sanchez, K., Moxon, N., Mellinger, S., Wu, Y., Koguchi, Y., Conrad, V., Redmond, W. L., Martel, M., Sun, Z., Campbell, M. B., Conlin, A., Acheson, A., Basho, R., McAndrew, P., El-Masry, M., Park, D., & 8 others , Dec 2023, In: npj Breast Cancer. 9, 1, 53.Research output: Contribution to journal › Article › peer-review
Open Access -
Challenges and opportunities in the development of combination immunotherapy with OX40 agonists
Redmond, W. L., 2023, In: Expert Opinion on Biological Therapy. 23, 9, p. 901-912 12 p.Research output: Contribution to journal › Review article › peer-review
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Characterization of murine lymphocyte activation and exhaustion markers by a 14-color flow cytometry panel
Rose, D. C., Rolig, A. S. & Redmond, W. L., Apr 1 2023, In: Bioanalysis. 15, 8, p. 429-447 19 p.Research output: Contribution to journal › Article › peer-review
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Enhancement of anti-tumor efficacy of immune checkpoint blockade by alpha-TEA
Redmond, W. L., Kasiewicz, M. J. & Akporiaye, E. T., 2023, In: Frontiers in Immunology. 14, 1057702.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
1171 CAN1012: a selective and potent TLR7 agonist with strong antitumoral properties mediated by localized innate immune activation
Yu, H., Redmond, W. L., Koguchi, Y. & comments, S. A. A. I., Jan 1 2022Research output: Other contribution